Accelerated healing of diabetic wounds by NorLeu3-angiotensin (1-7)

Expert Opinion on Investigational Drugs

Volumn 20, Issue 11, 2011, Pages 1575-1581

  Rodgers, Kathleen ^a,b   Verco, Shelagh ^c   Bolton, Laura ^d   Dizerega, Gere ^b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c US Biotest Inc   (United States)

^d ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Angiotensin; Dermal; Diabetes; NorLeu3 angiotensin 1 7; Wound healing

Indexed keywords

ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][3 NORLEUCINE]; BECAPLERMIN; PLACEBO; UNCLASSIFIED DRUG;

AMPUTATION; CHRONIC WOUND; DIABETES MELLITUS; DIABETIC PATIENT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESEARCH; HUMAN; MORBIDITY; OSTEOMYELITIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); REVIEW; ULCER; ULCER HEALING; WOUND HEALING;

ANGIOTENSIN II; ANIMALS; CLINICAL TRIALS AS TOPIC; DIABETES COMPLICATIONS; DRUG EVALUATION, PRECLINICAL; HUMANS; PEPTIDE FRAGMENTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; WOUND HEALING;

EID: 80053987489     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2011.619976     Document Type: Review

References (27)

1. Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet derived growth factor-BB (becaplermin) in patients with chronic neuropathic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care 1998;21(5):822-7 (Pubitemid 28487079)
2. Mrug M, Stopka T, Julian BA, et al. Angiotensin II stimulates proliferation of normal early erythroid progenitors. J Clin Invest 1997;100:2310-14 (Pubitemid 27500154)
3. Rodgers KE, Abiko M, Girgis W, et al. Acceleration of dermal tissue repair by angiotensin II. Wound Repair Regen 1997;5:175-83 (Pubitemid 127686789)
4. Rodgers KE, Xiong S, Steer R, diZerega GS. Effect of angiotensin II on hematopoietic progenitor cell proliferation. Stem Cells 2000;18:287-94 (Pubitemid 30602276)
5. Rodgers KE, Xiong S, diZerega GS. Effect of angiotensin II and angiotensin (1-7) on hematopoietic recovery after intravenous chemotherapy. Cancer Chemother Pharmacol 2003;51:97-106 (Pubitemid 36259469)
6. Ellefson DE, diZerega GS, Espinoza T, et al. Synergistic effects of co-administration of angiotensin 1-7 and Neupogen on hematopoietic recovery in mice. Cancer Chem Pharmacol 2004;53:15-24 (Pubitemid 38161184)
7. Rodgers KE, Ellefson DE, Espinoza T, et al. Fragments of Nle3-Angiotensin(1-7) accelerate healing in dermal models. J Pept Res 2005;66(Suppl 1):41-7
8. Steckelings UM, Wollschlager T, Peters J, et al. Human skin: source of and target organ for angiotensin II. Exp Dermatol 2004;13(3):148-54 (Pubitemid 38380278)
9. Steckelings UM, Henz BM, Wiehstutz S, et al. Differential expression of angiotensin receptors in human cutaneous wound. Br J Dermatol 2005;153(5):887-93. (Pubitemid 41540751)
10. Abiko M, Rodgers KE, Campeau JD, et al. Alterations in angiotensin II receptor levels in full thickness excisional wounds in rat skin. Wound Repair Regen 1996;4(3):363-7 (Pubitemid 126670853)
11. Abiko M, Rodgers KE, Campeau JD, et al. Alterations in angiotensin II receptor levels in sutured wounds in rat skin. J Invest Surg 1996;9:447-53 (Pubitemid 27022849)
12. Kimura B, Sumners C, Phillips MI. Changes in skin angiotensin II receptors in rats during wound healing. BBRC 1992;187:1083-90
13. Viswanathan M, Saavedra JM. Expression of angiotensin II AT2 receptors in rat skin during experimental wound healing. Peptides 1992;13:783-36
14. Kurosaka M, Suzuki T, Hosono K, et al. Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptordeficient mice. Biomed Pharmacother 2009;63(9):627-34
15. Zhang GY, Li X, Yi CG, et al. Angiotensin II activated connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen-activated protein kinase signaling pathways in human dermal fibroblasts. Exp Dermatol 2009;18(11):947-53
16. Tang HT, Cheng DC, Jia YT, et al. Angiotensin II induces type I collagen gene expression in human dermal fibroblasts through an AP-1/TGF-beta 1-dependent pathway. Biochem Biophys Res Commun 2009;385(3):418-23
17. Wu HF, Liu HW, Cheng B, et al. The change in angiotensin II production and its receptor expression during wound healing: possible role of angiotensin II in wound healing. Zhonghua Zheng Xing Wai Ke Za Shi 2011;27(2):124-8
18. Jadhav SS, Sharma N, Espinoza T, et al. Effects of combined thermal and radiation injury on the renin angiotensin system. Wound Repair Regen; Submitted
19. Rodgers KE, Xiong S, Felix JC, et al. Development of angiotensin (1-7) as an agent to accelerate dermal regeneration. Wound Repair Regen 2001;9:241-50
20. Jokubaitis VJ, Sinka L, Driessen R, et al. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal and adult hematopoietic tissues. Blood 2008;111(8):4055-63
21. Savary K, Michaud A, Favier J, et al. Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo. Blood 2008;105(1):103-10
22. Parks T, Zambidis ET. A role for the renin-angiotensin system in hematopoiesis. Hamaetologica 2009;94(6):745-7
23. Zambidis ET, Park TS, Yu W, et al. Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells. Blood 2008;112:3601-14
24. Lui HW, Cheng B, Li JF, et al. Characterization of angiotensin-converting enzyme expression during epidermis morphogenesis in humans: a potential marker for epidermal stem cells. Br J Dermatol 2009;160(2):250-8
25. Rodgers KE, Roda N, Felix JC, et al. Histological evaluation of the effects of angiotensin peptides on wound repair in diabetic mice. Exp Dermatol 2003;12:784-90. (Pubitemid 38035076)
26. Rodgers KE, Espinoza T, Felix J, et al. Acceleration of healing, reduction of fibrotic scar and normalization of tissue architecture by angiotensin analog, NorLeu3-A(1-7). Plast Reconstr Surg 2003;111:1195-206. (Pubitemid 36297420)
27. Balingat P, Reyzelman A, Armstrong D, et al. Randomized trial of a novel angiotensin analogue on diabetic foot ulcer healing. Foot Global Conference, Los Angeles, California, 23-26 March 2011