Characterization of angiotensin-converting enzyme expression during epidermis morphogenesis in humans: A potential marker for epidermal stem cells

British Journal of Dermatology

Volumn 160, Issue 2, 2009, Pages 250-258

  Liu, H W ^a   Cheng, B ^b   Li, J F ^c   Wu, H J ^a   Li, K Y ^a   Sun, T Z ^d   Fu, X B ^d  

^a JINAN UNIVERSITY   (China)

^b Guangzhou Liuhuaqiao Hospital   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

^d CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Angiotensin converting enzyme; Development; Fetus; Skin; Stem cell

Indexed keywords

BETA1 INTEGRIN; CYTOKERATIN 19; DIPEPTIDYL CARBOXYPEPTIDASE; PROTEIN P63;

ADULT; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME LOCALIZATION; EPIDERMIS; FETUS; FETUS DEATH; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MORPHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; STEM CELL;

ABORTED FETUS; BIOLOGICAL MARKERS; CELLS, CULTURED; EPIDERMIS; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KERATINOCYTES; MORPHOGENESIS; PEPTIDYL-DIPEPTIDASE A; STEM CELLS; WOUND HEALING;

EID: 58349097519     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08970.x     Document Type: Article

References (32)

1. Mack JA, Anand S, Maytin EV. Proliferation and cornification during development of the mammalian epidermis. Birth Defects Res C Embryo Today 2005 75 : 314 29.
2. Alonso L, Fuchs E. Stem cells of the skin epithelium. Proc Natl Acad Sci USA 2003 100 (Suppl. 1 11830 5.
3. Fleming I. Signaling by the angiotensin-converting enzyme. Circ Res 2006 98 : 887 96.
4. Scholzen TE, König S, Fastrich M et al. Terminating the stress: peripheral peptidolysis of proopiomelanocortin-derived regulatory hormones by the dermal microvascular endothelial cell extracellular peptidases neprilysin and angiotensin-converting enzyme. Endocrinology 2007 148 : 2793 805.
5. Bernstein KE. Views of the renin-angiotensin system: brilling, mimsy, and slithy tove. Hypertension 2006 47 : 509 14.
6. Scholzen TE, Ständer S, Riemann H et al. Modulation of cutaneous inflammation by angiotensin-converting enzyme. J Immunol 2003 170 : 3866 73.
7. Steckelings UM, Artuc M, Wollschläger T et al. Angiotensin- converting enzyme inhibitors as inducers of adverse cutaneous reactions. Acta Derm Venereol 2001 81 : 321 5.
8. Steckelings UM, Wollschläger T, Peters J et al. Human skin: source of and target organ for angiotensin II. Exp Dermatol 2004 13 : 148 54.
9. Morihara K, Takai S, Takenaka H et al. Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin. J Am Acad Dermatol 2006 54 : 251 7.
10. Scholzen TE, Luger TA. Neutral endopeptidase and angiotensin-converting enzyme - key enzymes terminating the action of neuroendocrine mediators. Exp Dermatol 2004 13 (Suppl. 4 22 6.
11. Romagnani P, Lasagni L, Mazzinghi B et al. Pharmacological modulation of stem cell function. Curr Med Chem 2007 14 : 1129 39.
12. Jokubaitis VJ, Sinka L, Driessen R et al. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Blood 2008 111 : 4055 63.
13. Strawn WB, Richmond RS, Tallant EA et al. Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells. Br J Haematol 2004 126 : 120 6.
14. Chisi JE, Wdzieczak-Bakala J, Thierry J et al. Captopril inhibits the proliferation of hematopoietic stem and progenitor cells in murine long-term bone marrow cultures. Stem Cells 1999 17 : 339 44.
15. Chisi JE, Briscoe CV, Ezan E et al. Captopril inhibits in vitro and in vivo the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation but has no effect on myeloid leukaemia cell proliferation. Br J Haematol 2000 109 : 563 70.
16. Kurdi M, De Mello WC, Booz GW. Working outside the system: an update on the unconventional behaviour of the renin-angiotensin system components. Int J Biochem Cell Biol 2005 37 : 1357 67.
17. Lepore DA, Jokubaitis VJ, Simmons PJ et al. A role for angiotensin-converting enzyme in the characterization, enrichment, and proliferation potential of adult murine pituitary colony-forming cells. Stem Cells 2006 24 : 2382 90.
18. Liu HW, Cheng B, Yu WL et al. Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars. Life Sci 2006 79 : 475 83.
19. Cheng B, Liu HW, Fu XB et al. Coexistence and upregulation of three types of opioid receptors, mu, delta and kappa, in human hypertrophic scars. Br J Dermatol 2008 158 : 713 20.
20. Potten CS, Booth C. Keratinocyte stem cells: a commentary. J Invest Dermatol 2002 119 : 888 99.
21. Michel M, Török N, Godbout MJ et al. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. J Cell Sci 1996 109 : 1017 28.
22. Liu HW, Cheng B, Fu XB et al. Characterization of AT1 and AT2 receptor expression profiles in human skin during fetal life. J Dermatol Sci 2007 46 : 221 5.
23. Steckelings UM, Henz BM, Wiehstutz S et al. Differential expression of angiotensin receptors in human cutaneous wound healing. Br J Dermatol 2005 153 : 887 93.
24. Hertle MD, Adams JC, Watt FM. Integrin expression during human epidermal development in vivo and in vitro. Development 1991 112 : 193 206.
25. Fuchs E, Byrne C. The epidermis rising to the surface. Curr Opin Genet Dev 1994 4 : 725 36.
26. Fuchs E. Scratching the surface of skin development. Nature 2007 445 : 834 42.
27. Bickenbach JR, Holbrook KA. Label-retaining cells in human embryonic and fetal epidermis. J Invest Dermatol 1987 88 : 42 6.
28. Kai-Hong J, Jun X, Kai-Meng H et al. p63 expression pattern during rat epidermis morphogenesis and the role of p63 as a marker for epidermal stem cells. J Cutan Pathol 2007 34 : 154 9.
29. Truong AB, Kretz M, Ridky TW et al. p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 2006 20 : 3185 97.
30. Lorenz K, Grashoff C, Torka R et al. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol 2007 17 : 501 13.
31. Narasimha M, Brown NH. Novel functions for integrins in epithelial morphogenesis. Curr Biol 2004 14 : 381 5.
32. Larouche D, Hayward C, Cuffley K et al. Keratin 19 as a stem cell marker in vivo and in vitro. Methods Mol Biol 2005 289 : 103 10.