Synthesis of vitcamphor derivatives of camphor and its preliminary anti-inflammatory activity

Proceedings 2011 International Conference on Human Health and Biomedical Engineering, HHBE 2011

Volumn , Issue , 2011, Pages 88-91

  Shuang, Jiang ^a   Tancheng, Li ^a   Peige, Du ^a   Yufeng, Sun ^b   Lin, Lin ^b   Yiguo, Liu ^b  

^a BEIHUA UNIVERSITY   (China)

^b Changchun Dazheng Tecnologia Farmaceutica Co Ltd   (China)

Author keywords

anti inflammatory; synthesis; vitcamphor

Indexed keywords

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY ACTIVITY; INHIBITORY EFFECT; TARGET COMPOUND; VASCULAR PERMEABILITY; VITCAMPHOR;

MAMMALS;

BIOMEDICAL ENGINEERING;

EID: 80053970083     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/HHBE.2011.6027903     Document Type: Conference Paper

References (19)

1. Homma H, Ono H. Effect of trans-pi-vitcamphor on cough and respiratory rales and its action mechanism[J]. Nippon Shonika Gakkai Zasshi, 1969, 73(3):364-73.
2. Fujii S, Inada S, Yoshida S. Pharmacological studies on doping drugs for race horses trans-pai-vitcamphor[J]. Nippon Juigaku Zasshi, 1970, 32(6):307-17.
3. Baba T, Taniguchi S. Improvement of cancer therapy by angiotensin II-induced hypertension chemotherapy [J]. Gan To Kagaku Ryoho. 1987 Mar;14(3 Pt 2):971-7. Japanese. (Pubitemid 17041124)
4. Baba T, Aoki K, Kuroiwa T, Taniguchi S.Some cardiotonics enhance the effectiveness of angiotensin II-induced hypertension cancer chemotherapy in mice[J]. Jpn J Cancer Res. 1986 May;77(5):432-5. (Pubitemid 16088144)
5. Suzue T.Respiratory rhythm generation in the in vitro brain stemspinal cord preparation of the neonatal rat[J].J Physiol. 1984 Sep;354:173-83. (Pubitemid 14066361)
6. Kumagai H, Sakai F, Hukuhara T. Site of action trans-pi-vitcamphor in the central nervous system of the cat[J]. Jpn J Pharmacol,1964, 14(5) : 229-30.
7. Morizo I, Gyokujo K, Yasuhiko A. Method of manufacturing vitcamphor: US Patent, 1933642(A) [P]. 1933-07-11.
8. Grabda M, Oleszek-Kudlak S, Shibata E, et al. Influence of temperature and heating time on bromination of zinc oxide during thermal treatment with tetrabromobisphenol A[J]. Environ Sci Techno, 2009, 43(23): 8936-8941.
9. Maji B, Vedachalan S, Ge X, Cai S, et al. N-heterocyclic carbenemediated oxidative esterification of aldehydes: ester formation and mechanistic studies[J].J Org Chem, 2011, 76(9):3016-23.
10. Motoyama Y, Aoki M, Takaoka N, et al. Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silanereduction/ dehydration under mild conditions[J].Chem Commun, 2009, 8 (12):1574-1576.
11. Vig BS, Lorenzi PJ, Mittal S, et al. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis[J]. Pharm Res, 2003, 20(9):1381-1388. (Pubitemid 37164045)
12. Miao CX, Wang JQ, Yu B, et al. Synthesis of bimagnetic ionic liquid and application for selective aerobic oxidation of aromatic alcohols under mild conditions[J]. Chem Commun, 2011, 47(9):2697-9.
13. Pakneshan P, Birsner AE, Adini I, et al. Differential suppression of vascular permeability and corneal angiogenesis by nonsteroidal antiinflammatory drugs[J]. nvest Ophthalmol Vis Sci, 2008, 49(9): 3909- 3913.
14. Olajide OA, Okpako DT, Makinde JM. Olajide OA, Okpako DT, Makinde JM. Anti-inflammatory properties of Bridelia ferruginea stem bark. Inhibition of lipopolysaccaride-induced septic shock and vascular permeability[J]. Ethnopharmacol, 2003, 88(23): 221-224. (Pubitemid 37083450)
15. Tan-No K, Nakajima T, Shoji T, Nakagawasai O, et al. Antiinflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema[J]. Biol Pharm Bull, 2006, 29(1): 96-99. (Pubitemid 43036702)
16. Abiko T, Ogawa R. Syntheses of two deacetyl-thymosin beta4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw[J]. Mediators Inflamm. 2001, 10(2): 89-92. (Pubitemid 32522164)
17. Ravi P, Khaled H. Synthesis and biological activities of camphor based non-peptide growth hormone secretagogues[J]. Bioorganic and Medicinal Chemistry Letters, 1996, 11(6): 1265-1270
18. Yousifm HM, Oriowo MA, Cherian A, et al . Histamine induced vasodilatation in the perfused mesenteric arterial bed of diabetic rats[J]. Vasc Pharmacol, 2002, 39: 287-292. (Pubitemid 36830731)
19. Chen XH, Bai JY, Shen F, et al. Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect [J]. Acta Pharmacol Sin, 2004, 25: 927-931. (Pubitemid 38915452)