Freeze-drying of an active principle ingredient using organic co-solvent formulations: Influence of freezing conditions and formulation on solvent crystals morphology, thermodynamics data, and sublimation kinetics

Drying Technology

Volumn 29, Issue 16, 2011, Pages 1858-1867

  Daoussi, Rim ^a,b   Bogdani, Eni ^a   Vessot, Severine ^a   Andrieu, Julien ^a   Monnier, Olivier ^c  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^c SANOFI   (France)

Author keywords

Crystals morphology; Freeze drying; Frozen solvent vapor pressures; Sublimation enthalpies; Sublimation kinetics; Tert butanol

Indexed keywords

ACTIVE PRINCIPLES; COSOLVENTS; EQUILIBRIUM VAPOR; EUTECTIC COMPOSITION; FREEZE-DRYING; FREEZING CONDITIONS; FREEZING RATE; FROZEN SOLVENTS; LITERATURE DATA; MEAN SIZE; PURE WATER; SOLID-VAPOR; SOLVENT CONCENTRATION; SUBLIMATION ENTHALPIES; SUBLIMATION ENTHALPY; TERT BUTANOL; THERMODYNAMICAL PROPERTIES; THERMODYNAMICS DATA; WATER BASED;

ALCOHOLS; CRYSTALS; DRYING; ENTHALPY; FREEZING; HYDROSTATIC PRESSURE; KINETICS; LOW TEMPERATURE DRYING; MORPHOLOGY; ORGANIC SOLVENTS; SUBLIMATION; THERMODYNAMICS; VAPOR PRESSURE; WATER VAPOR;

SOLVENTS;

EID: 80053967152     PISSN: 07373937     EISSN: 15322300     Source Type: Journal    
DOI: 10.1080/07373937.2011.569624     Document Type: Article

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