Serotonin 2A receptors in obsessive-compulsive disorder: A positron emission tomography study with [ 11C]MDL 100907

Biological Psychiatry

Volumn 70, Issue 9, 2011, Pages 897-904

  Simpson, Helen Blair ^a,b   Slifstein, Mark ^a,b   Bender Jr , James ^b   Xu, Xiaoyan ^b   Hackett, Elizabeth ^b   Maher, Michael J ^b   Abi Dargham, Anissa ^a,b  

^a College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

5 HT 2A receptor; 11C MDL 100907; obsessive compulsive disorder; orbitofrontal cortex; positron emission tomography (PET); serotonin receptors

Indexed keywords

CARBON 11; SEROTONIN 2A RECEPTOR; VOLINANSERIN;

ADULT; ANTERIOR CINGULATE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DISTRIBUTION VOLUME; ENTORHINAL CORTEX; FEMALE; HUMAN; INSULA; MALE; MIDDLE TEMPORAL GYRUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSESSIVE COMPULSIVE DISORDER; OCCIPITAL CORTEX; ORBITAL CORTEX; PARAHIPPOCAMPAL GYRUS; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; TEMPORAL CORTEX; VENTROMEDIAL PREFRONTAL CORTEX; VOXEL BASED MORPHOMETRY;

ADOLESCENT; ADULT; AGE OF ONSET; FEMALE; FLUOROBENZENES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; ISOTOPE LABELING; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PSYCHIATRIC STATUS RATING SCALES; RADIOPHARMACEUTICALS; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN ANTAGONISTS; YOUNG ADULT;

EID: 80053948079     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.06.023     Document Type: Article

References (47)

1. S. Saxena, R.G. Bota, and A.L. Brody Brain-behavior relationships in obsessive-compulsive disorder Semin Clin Neuropsychiatry 6 2001 82 101
2. M.L. Carlsson On the role of cortical glutamate in obsessive-compulsive disorder and attention-deficit hyperactivity disorder, two phenomenologically antithetical conditions Acta Psychiatr Scand 102 2000 401 413
3. C. Pittenger, J.H. Krystal, and V. Coric Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder NeuroRx 3 2006 69 81 (Pubitemid 43276634)
4. F.P. MacMaster, J. O'Neill, and D.R. Rosenberg Brain imaging in pediatric obsessive-compulsive disorder J Am Acad Child Adolesc Psychiatry 47 2008 1262 1272
5. D.R. Rosenberg, S.N. MacMillan, and G.J. Moore Brain anatomy and chemistry may predict treatment response in paediatric obsessive-compulsive disorder Int J Neuropsychopharmacol 4 2001 179 190 (Pubitemid 32587386)
6. L.C. Barr, W.K. Goodman, L.H. Price, C.J. McDougle, and D.S. Charney The serotonin hypothesis of obsessive compulsive disorder: Implications of pharmacologic challenge studies J Clin Psychiatry 53 suppl 1992 17 28
7. S.L. Rauch, G. Cora-Locatelli, and B.D. Greenberg Pathogenesis of obsessive-compulsive disorder D.J. Stein, E. Hollander, Textbook of Anxiety Disorders 2002 The American Psychiatric Publishing Washington, DC 191 205
8. M. Slifstein PET Imaging I. Stolerman, Encyclopedia of Psychopharmacology 2010 Springer-Verlag Berlin
9. H.B. Simpson, I. Lombardo, M. Slifstein, H.Y. Huang, D.R. Hwang, and A. Abi-Dargham Serotonin transporters in obsessive-compulsive disorder: A positron emission tomography study with [(11)C]McN 5652 Biol Psychiatry 54 2003 1414 1421 (Pubitemid 37522166)
10. R. Matsumoto, M. Ichise, H. Ito, T. Ando, H. Takahashi, and Y. Ikoma Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: A [11C]DASB PET study Neuroimage 49 2010 121 126
11. R.L. Jakab, and P.S. Goldman-Rakic Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex J Comp Neurol 417 2000 337 348 (Pubitemid 30080377)
12. D.L. Willins, A.Y. Deutch, and B.L. Roth Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex Synapse 27 1997 79 82 (Pubitemid 27327604)
13. M. El Mansari, and P. Blier Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder Prog Neuropsychopharmacol Biol Psychiatry 30 2006 362 373 (Pubitemid 43841738)
14. D. Perani, V. Garibotto, A. Gorini, R.M. Moresco, M. Henin, and A. Panzacchi In vivo PET study of 5HT(2A) serotonin and D(2) dopamine dysfunction in drug-naive obsessive-compulsive disorder Neuroimage 42 2008 306 314
15. R. Hinz, Z. Bhagwagar, P.J. Cowen, V.J. Cunningham, and P.M. Grasby Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907 J Cereb Blood Flow Metab 27 2007 161 172 (Pubitemid 46006594)
16. K.H. Adams, E.S. Hansen, L.H. Pinborg, S.G. Hasselbalch, C. Svarer, and S. Holm Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei Int J Neuropsychopharmacol 8 2005 391 401 (Pubitemid 41002493)
17. P.Z. Tan, R.M. Baldwin, C.H. Van Dyck, M. Al-Tikriti, B. Roth, and N. Khan Characterization of radioactive metabolites of 5-HT2A receptor PET ligand [18F]altanserin in human and rodent Nucl Med Biol 26 1999 601 608 (Pubitemid 29424146)
18. H. Hall, L. Farde, C. Halldin, C. Lundkvist, and G. Sedvall Autoradiographic localization of 5-HT(2A) receptors in the human brain using [(3)H]M100907 and [(11)C]M100907 Synapse 38 2000 421 431
19. Talbot PS, Slifstein M, Hwang D-R, Huang Y, Scher E, Abi-Dargham A, Laruelle M (in press): Extended characterization of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in healthy humans. NeuroImage. doi:10.1016/j.neuroimage.2011.07.001.
20. M.M. Weissman, P. Wickramaratne, P. Adams, S. Wolk, H. Verdeli, and M. Olfson Brief screening for family psychiatric history: The family history screen Arch Gen Psychiatry 57 2000 675 682 (Pubitemid 30445859)
21. M.B. First, R.L. Spitzer, M. Gibbon, and J.B. Williams Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition 1996 Biometrics Research Department, New York State Psychiatric Institute New York
22. W.K. Goodman, L.H. Price, S.A. Rasmussen, C. Mazure, R.L. Fleischmann, and C.L. Hill The Yale-Brown Obsessive Compulsive Scale I. Development, use, and reliability Arch Gen Psychiatry 46 1989 1006 1011 (Pubitemid 19278229)
23. W.K. Goodman, L.H. Price, S.A. Rasmussen, C. Mazure, P. Delgado, G.R. Heninger, and D.S. Charney The Yale-Brown Obsessive Compulsive Scale II. Validity Arch Gen Psychiatry 46 1989 1012 1016 (Pubitemid 19278230)
24. M. Hamilton A rating scale for depression J Neurol Neurosurg Psychiatry 23 1960 56 62
25. A. Pinto, J.L. Eisen, M.C. Mancebo, B.D. Greenberg, R.L. Stout, and S.A. Rasmussen Taboo thoughts and doubt/checking: a refinement of the factor structure for obsessive-compulsive disorder symptoms Psychiatry Res 151 2007 255 258 (Pubitemid 46829414)
26. A. Pinto, B.D. Greenberg, D.L. Murphy, G. Nestadt, and S.A. Rasmussen Using individual items to clarify OCD symptom structure: The case for five factors Am J Psychiatry 166 2009 728 729 author reply 729731
27. A. Pinto, B.D. Greenberg, M.A. Grados, O.J. Bienvenu 3rd, J.F. Samuels, and D.L. Murphy Further development of YBOCS dimensions in the OCD Collaborative Genetics study: Symptoms vs. categories Psychiatry Res 160 2008 83 93
28. C. Lundkvist, C. Halldin, N. Ginovart, S. Nyberg, C.G. Swahn, and A.A. Carr [11C]MDL 100907, a radioligand for selective imaging of 5-HT(2A) receptors with positron emission tomography Life Sci 58 1996 187 192
29. A. Abi-Dargham, O. Mawlawi, I. Lombardo, R. Gil, D. Martinez, and Y. Huang Prefrontal dopamine D1 receptors and working memory in schizophrenia J Neurosci 22 2002 3708 3719 (Pubitemid 37465776)
30. A. Abi-Dargham, D. Martinez, O. Mawlawi, N. Simpson, D.R. Hwang, and M. Slifstein Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: Validation and reproducibility J Cereb Blood Flow Metab 20 2000 225 243 (Pubitemid 30108440)
31. A. Abi-Dargham, M. Laruelle, J. Seibyl, Z. Rattner, R.M. Baldwin, and S.S. Zoghbi SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms J Nucl Med 35 1994 228 238 (Pubitemid 24048309)
32. P.S. Talbot, W.G. Frankle, D.R. Hwang, Y. Huang, R.F. Suckow, and M. Slifstein Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans Synapse 55 2005 164 175 (Pubitemid 40194718)
33. L.S. Kegeles, M. Slifstein, W.G. Frankle, X. Xu, E. Hackett, and S.A. Bae Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride Neuropsychopharmacology 33 2008 3111 3125
34. J. Ashburner, and K. Friston Multimodal image coregistration and partitioninga unified framework Neuroimage 6 1997 209 217 (Pubitemid 27488452)
35. C. Studholme, D.L. Hill, and D.J. Hawkes Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multiresolution optimization of voxel similarity measures Med Phys 24 1997 25 35 (Pubitemid 27051930)
36. M. Laruelle, M. Slifstein, and Y. Huang Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography Mol Imaging Biol 5 2003 363 375 (Pubitemid 37489827)
37. R.B. Innis, V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, and R.N. Gunn Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 2007 1533 1539 (Pubitemid 47301451)
38. M.A. Mintun, M.E. Raichle, M.R. Kilbourn, G.F. Wooten, and M.J. Welch A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography Ann Neurol 15 1984 217 227 (Pubitemid 14164735)
39. A. Okasha, M. Rafaat, N. Mahallawy, G. El Nahas, A.S. El Dawla, M. Sayed, and S. El Kholi Cognitive dysfunction in obsessive-compulsive disorder Acta Psychiatr Scand 101 2000 281 285 (Pubitemid 30173577)
40. R.B. Innis, V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, and R.N. Gunn Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 2007 1533 1539 (Pubitemid 47301451)
41. Y. Benjamini, and Y. Hochberg Controlling the false discovery ratea practical and powerful approach to multiple testing J R Stat Soc Series B Stat Methodol 57 1995 289 300
42. G.F. Busatto, C.A. Buchpiguel, D.R. Zamignani, G.E. Garrido, M.F. Glabus, and M.C. Rosario-Campos Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: An exploratory SPECT study J Am Acad Child Adolesc Psychiatry 40 2001 347 354 (Pubitemid 32179970)
43. C. Huyser, D.J. Veltman, E. de Haan, and F. Boer Paediatric obsessive-compulsive disorder, a neurodevelopmental disorder? Evidence from neuroimaging Neurosci Biobehav Rev 33 2009 818 830
44. D.E. Dickel, J. Veenstra-VanderWeele, N.C. Bivens, X. Wu, D.J. Fischer, and M. Van Etten-Lee Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder Biol Psychiatry 61 2007 322 329 (Pubitemid 46108693)
45. D.E. Dickel, J. Veenstra-VanderWeele, N.J. Cox, X. Wu, D.J. Fischer, and M. Van Etten-Lee Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder Arch Gen Psychiatry 63 2006 778 785
46. Z. Bhagwagar, R. Hinz, M. Taylor, S. Fancy, P. Cowen, and P. Grasby Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: A positron emission study with [(11)C]MDL 100,907 Am J Psychiatry 163 2006 1580 1587 (Pubitemid 44465759)
47. J.H. Meyer, S. McMain, S.H. Kennedy, L. Korman, G.M. Brown, and J.N. DaSilva Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm Am J Psychiatry 160 2003 90 99 (Pubitemid 36042431)