Inhibitors of Src and focal adhesion kinase promote endocrine specification: Impact on the derivation of β-cells from human pluripotent stem cells

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 36042-36052

  Afrikanova, Ivka ^a,b   Yebra, Mayra ^a,b   Simpkinson, Megan ^a,b   Xu, Yang ^b   Hayek, Alberto ^a,b   Montgomery, Anthony ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL-BASED THERAPY; CYCLIN-DEPENDENT KINASE INHIBITORS; DOMINANT NEGATIVE; FOCAL ADHESION KINASE; HUMAN EMBRYONIC STEM CELLS; LOW LEVEL; PLURIPOTENT STEM CELLS; SELECTIVE INHIBITION; SIGNALING EVENTS; SPECIFICATION LIMIT; SRC-FAMILY KINASE; STEPWISE APPROACH;

ADHESION; CELL GROWTH; ENZYMES; SPECIFICATIONS; STEM CELLS; TRANSCRIPTION FACTORS;

CYTOLOGY;

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 1C; FOCAL ADHESION KINASE; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; PROTEIN TYROSINE KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR PAX4; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDOCRINE FUNCTION; ENDOCRINE SPECIFICATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P57; DIABETES MELLITUS; EMBRYONIC STEM CELLS; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INHIBITOR OF DIFFERENTIATION PROTEIN 2; INSULIN-SECRETING CELLS; PLURIPOTENT STEM CELLS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SRC-FAMILY KINASES; TISSUE THERAPY;

EID: 80053924005     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.290825     Document Type: Article

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