Uric acid levels and all-cause and cardiovascular mortality in the hemodialysis population

Clinical Journal of the American Society of Nephrology

Volumn 6, Issue 10, 2011, Pages 2470-2477

  Latif, Walead ^a   Karaboyas, Angelo ^b   Tong, Lin ^b   Winchester, James F ^a   Arrington, Charlotte J ^b   Pisoni, Ronald L ^b   Marshall, Mark R ^c   Kleophas, Werner ^d   Levin, Nathan W ^e   Sen, Ananda ^f   Robinson, Bruce M ^b,f   Saran, Rajiv ^f  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ARBOR RESEARCH COLLABORATIVE FOR HEALTH   (United States)

^c MIDDLEMORE HOSPITAL   (New Zealand)

^d Gemeinschaftspraxis Karlstrasse   (Germany)

^e RENAL RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALBUMIN; ALLOPURINOL; CALCIUM; CREATININE; DIURETIC AGENT; PHOSPHORUS; URIC ACID;

ACUTE HEART INFARCTION; ADULT; ARTICLE; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; AUSTRALIA; BELGIUM; BODY MASS; BRAIN DISEASE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CALCIUM BLOOD LEVEL; CANADA; CARDIOMYOPATHY; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; COMORBIDITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; FEMALE; FRANCE; GERMANY; HAZARD RATIO; HEART ARREST; HEART ARRHYTHMIA; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; HYPERURICEMIA; ITALY; JAPAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; NEW ZEALAND; OUTCOME ASSESSMENT; PHOSPHATE BLOOD LEVEL; POPULATION; POTASSIUM BLOOD LEVEL; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL; SPAIN; SWEDEN; UNITED KINGDOM; UNITED STATES; URIC ACID BLOOD LEVEL;

ADULT; AGED; AUSTRALIA; BIOLOGICAL MARKERS; CANADA; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; CLUSTER ANALYSIS; EUROPE; FEMALE; HUMANS; HYPERURICEMIA; JAPAN; KIDNEY DISEASES; LOGISTIC MODELS; MALE; MIDDLE AGED; NEW ZEALAND; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RENAL DIALYSIS; RISK ASSESSMENT; RISK FACTORS; UNITED STATES; URIC ACID;

EID: 80053920803     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.00670111     Document Type: Article

References (34)

1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu C: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351: 1296-1305, 2004
2. Cheung AK, Sarnak MJ, Yan G, Berkoben M, Heyka R, Kaufman A, Lewis J, Rocco M, Toto R, Windus D, Ornt D, Levey AS, HEMO Study Group: Cardiac diseases in maintenance hemodialysis patients: Results of the HEMO Study. Kidney Int 65: 2380-2389, 2004
3. Johnson RJ, Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M: Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41: 1183-1190, 2003
4. Jonasson T, Ohlin AK, Gottsäter A, Hultberg B, Ohlin H: Plasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease - a prospective randomized study of vitamin supplementation. Clin Chem Lab Med 43: 628-634, 2005
5. Niskanen LK, Laaksonen DE, Nyyssönen K, Alfthan G, Lakka HM, Lakka TA, Salonen JT: Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: A prospective cohort study. Arch Intern Med 164: 1546-1551, 2004
6. Ford ES, Li C, Cook S, Choi HK: Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 115: 2526-2532, 2007
7. Choi HK, Ford ES: Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 120: 442-447, 2007
8. Madero M: High levels of uric acid linked to CKD death risk. Renal Urol News July 11, 2008
9. Caravaca F, Martin MV, Barroso S, Cancho B, Arrobas M, Luna E, Sa ́nchez-Casado E: Serum uric acid and C-reactive protein levels in patients with chronic kidney disease. Nefrologia 25: 645-654, 2005
10. Suliman ME, Johnson RJ, García-López E, Qureshi AR, Molinaei H, Carrero JJ, Heimbürger O, Bárány P, Axelsson J, Lindholm B, Stenvinkel P: J-shaped mortality relationship for uric acid in CKD. Am J Kidney Dis 48: 761-771, 2006
11. Lee SM, Lee AL, Winters TJ, Tam E, Jaleel M, Stenvinkel P, Johnson RJ: Low serum uric acid level is a risk factor for death in incident hemodialysis patients. Am J Nephrol 29: 79-85, 2009
12. Hsu SP, Pai ME, Peng YS, Chiang CK, Ho TI, Hung KY: Serum uric acid levels show a 'J-shaped' association with allcause mortality in haemodialysis patients. Nephrol Dial Transplant 19: 457-462, 2004
13. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, Rimm EB: Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351: 2599-2610, 2004
14. Kalantar-Zadeh K, Kilpatrick R, McAllister C, Greenland S, Kopple JD: Reverse epidemiology of hypertension and cardiovascular death in the hemodialysis population: The 58th annual fall conference and scientific sessions. Hypertension 45: 811, 2005
15. Kalantar-Zadeh K, Abbott K, Salahudeen A, Kilpatrick RD, Horwich TB: Survival advantages of obesity in dialysis patients. Am J Clin Nutrition 81: 543-554, 2005
16. Dialysis Outcomes and Practice Patterns Study. Available at: http://www.dopps.org. Accessed August 9, 2011
17. Young EW, Goodkin DA, Mapes DL, Port FK, Keen ML, Chen K, Maroni BL, Wolfe RA, Held PJ: The Dialysis Outcomes and Practice Patterns Study (DOPPS): An international hemodialysis study. Kidney Int 57 [suppl 74]: S74-S81, 2000
18. Pisoni RL, Gillespie BW, Dickinson DM, Chen K, Kutner M, Wolfe RA: The Dialysis Outcomes and Practice Patterns Study (DOPPS): Design, data elements, and methodology. Am J Kidney Dis 44 [Suppl 2]: S7-S15, 2004
19. SAS Institute, Inc. SAS/STAT user's guide, Version 8, Volume 2, SAS Institute, Cary, NC, 2000, p 1452
20. Raghunathan TE, Lepkowski JM, van Hoewyk M, Solenberger PW: A multivariate technique for multiply imputing missing values using a sequence of regression models. Survey Methodol 27: 85-95, 2001. For associated IVEware software, see http://www.isr.umich.edu/src/smp/ive
21. Little RJA, Rubin DB: Statistical analysis with missing data, Hoboken NJ, John Wiley & Sons, 2002
22. Little RJA, Rubin DB: Statistical analysis with missing data, 2nd Ed. Hoboken, NJ, John Wiley & Sons, 2002
23. Høieggen A, Alderman MH, Kjeldsen SE, Julius S, Devereux RB, De Faire U, Fyhrquist F, Ibsen H, Kristianson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H, Chen C, Dahlöf B; LIFE Study Group: The impact of serum uric acid on cardiovascular outcomes in the LIFE study. Kidney Int 65: 1041-1049, 2004
24. Wanner C, Krane V, Rug G, Marz W, Ritz E: Rationale and design of a trial improving outcome of type 2 diabetics on hemodialysis. Die Deutsche Diabetes Dialyse Studie Investigators. Kidney Int Suppl 71: S222-S226, 1999
25. Liu Y, Coresh J, Eustace JA, Longenecker JC, Jaar B, Fink NE, Tracy RP, Powe NR, Klag MJ: Association between cholesterol level and mortality in dialysis patients: Role of inflammation and malnutrition. JAMA 291: 451-459, 2004
26. Suliman M, Stenvinkel P, Qureshi AR, Kalantar-Zadeh K, Barany P, Heimburger O, Vonesh EF, Lindholm B: The reverse epidemiology of plasma total homocysteine as a mortality risk factor is related to the impact of wasting and inflammation. Nephrol Dial Transplant 22: 209-217, 2007
27. Scholze A, Rattensperger D, Zidek W, Tepel M: Low serum leptin predicts mortality in patients with chronic kidney disease stage 5. Obesity 15: 1617-1622, 2007
28. Scholze A, Tepel M: Role of leptin in reverse epidemiology in chronic kidney disease. Semin Dial 20: 534-538, 2007
29. Suzuki T, Nishigawara O: Nitrosation of uric acid induced by nitric oxide under aerobic conditions. Nitric Oxide 16: 266-273, 2007
30. Cappuccio FP, Strazzullo P, Farinaro E, Trevisan M: Uric acid metabolism and tubular sodium handling: Results from a population-based study. JAMA 270: 354-359, 1993
31. Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG: Serum uric acid in essential hypertension: An indicator of renal vascular involvement. Ann Intern Med 93: 817-821, 1980
32. Quiñones Galvan A, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D, Ferrannini E: Effect of insulin on uric acid excretion in humans. Am J Physiol 268: E1-E5, 1995
33. Heistad DD, Wakisaka Y, Miller J, Chu Y, Pena-Silva R: Novel aspects of oxidative stress in cardiovascular diseases. Circ J 73: 201-207, 2009
34. Madamanchi NR, Hakim ZS, Runge MS: Oxidative stress in atherogenesis and arterial thrombosis: The disconnect between cellular studies and clinical outcomes. J Thromb Haemost 3: 254-267, 2005