Low serum uric acid level is a risk factor for death in incident hemodialysis patients

American Journal of Nephrology

Volumn 29, Issue 2, 2009, Pages 79-85

  Lee, S M Kurt ^a   Lee, Andrew L ^a   Winters, Thomas J ^a   Tam, Emily ^a   Jaleel, Mohammed ^a   Stenvinkel, Peter ^b   Johnson, Richard J ^c  

^a Biotronics Kidney Center   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Hemodialysis, comorbidity; Hypoalbuminemia; Serum uric acid, mortality

Indexed keywords

ALBUMIN; URIC ACID;

ADOLESCENT; ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CARDIOVASCULAR RISK; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEMODIALYSIS; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; SURVIVAL; URIC ACID BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CAUSE OF DEATH; COMORBIDITY; FEMALE; HUMANS; HYPOALBUMINEMIA; INCIDENCE; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; RENAL DIALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS; URIC ACID; YOUNG ADULT;

EID: 48749123104     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151292     Document Type: Article

References (18)

1. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M: Is there a pathogenetic role for uric acid in hypertension, cardiovascular and renal disease? Hypertension 2003;41:1183-1190.
2. Hsu SP, Pai MF, Peng YS, Chiang CK, Ho TI, Hung KY: Serum uric acid levels show a 'J-shaped' association with all-cause mortality in haemodialysis patients. Nephrol Dial Transplant 2004;19:457-462.
3. Suliman ME, Johnson RJ, Garcia-Lopez E, Qureshi AR, Molinai H, Carrero JJ, Heimburger O, Barany P, Axelsson J, Lindholm B, Stenvinkel P: J shaped mortality relationship for uric acid in CKD. Am J Kidney Dis 2006;48:761-771.
4. Ames BN, Cathcart R, Schwiers E, Hochstein P: Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 1981;78:6858-6862.
5. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39(2 suppl 1):S1-S266.
6. US Renal Data System:1999 Annual Data Report. Bethesda, National Institutes of Health, 1999, pp Li-Lvi.
7. Wolfe RA, Ashby VB, Port FK:1993 DMMS Comorbidity Index validated by medical evidence form data. J Am Soc Nephrol 2000;11:247A.
8. Hsu CY, McCullouch CE, Iribarren C, Darbinian J, Go AS: Body mass index and risk for end-stage renal disease. Ann Intern Med 2006;144:21-28.
9. Fossati P, Prencipe L, Berti G: Use of 3,5-dichloride-2- hydroxybenzenesulfonic acid/4-aminophenazone chromomeric system in direct enzymic assay of uric acid in serum and urine. Clin Chem 1980;26:227-231.
10. US Renal Data System:2007 Annual Data Report. Bethesda, National Institutes for Health, 2007, p 93.
11. Kand'ar R, Záková P, Muzáková V: Monitoring of antioxidant properties of uric acid in humans for a consideration measuring of levels of allantoin in plasma by liquid chromatography. Clin Chim Acta 2006;365:249-256.
12. Sorenson LB: Role of the intestinal tract in the elimination of uric acid. Arthritis Rheum 1965;8:694-706.
13. Kalantar-Zadeh K, Horwich TB, Oreopoulos A, Kovesdy CP, Younessi H, Anker SD, Morley JE: Risk factor paradox in wasting diseases. Curr Opin Clin Nutr Metab Care 2007;10:433-442.
14. Carrero JJ, Qureshi AR, Axelsson J, Avesani CM, Suliman ME, Kato S, Barany P, Snaedal-Jonsdottir S, Alvestrand A, Heimburger P, Lindholm B, Stenvinkel P: Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite. Am J Clin Nutr 2007;8:695-701.
15. Stenvinkel P: Inflammation in end-stage renal disease: the hidden enemy. Nephrology (Carlton) 2006;11:36-41.
16. Goodkin DA, Young EW, Kurokawa K, Prütz KG, Levin NW: Mortality among hemodialysis patients in Europe, Japan, and the United States: case-mix effects. Am J Kidney Dis 2004;44(suppl 2):16-21.
17. Kopple JD: The phenomenon of altered risk factor patterns or reverse epidemiology in persons with advanced chronic kidney failure. Am J Clin Nutr 2005;81:1257-1266.
18. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple J: Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003;63:793-808.