Structural modification of honokiol, a biphenyl occurring in magnolia officinalis: The evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6469-6481

  Ma, Liang ^a   Chen, Jinying ^a   Wang, Xuewei ^a   Liang, Xiaolin ^a   Luo, Youfu ^a   Zhu, Wei ^a   Wang, Tianen ^a   Peng, Ming ^a   Li, Shucai ^a   Jie, Shi ^a   Peng, Aihua ^a   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHYLBUT 3 EN 2 YL) 3' NITRO (1,1' BIPHENYL) 4 OL; 3 ALLYL (1,1' BIPHENYL) 4 OL; 3 ALLYL 2' (TRIFLUOROMETHYL) (1,1' BIPHENYL) 4 OL; 3 ALLYL 2',4' DIMETHOXY (1,1' BIPHENYL) 4 OL; 3 ALLYL 3' (METHYLTHIO) (1,1' BIPHENYL) 4 OL; 3 ALLYL 3' (TRIFLUOROMETHYL) (1,1' BIPHENYL) 4 OL; 3 ALLYL 3' METHOXY (1,1' BIPHENYL) 4 OL; 3 ALLYL 3' NITRO (1,1' BIPHENYL) 4 OL; 3 ALLYL 3',4' DIMETHOXY (1,1' BIPHENYL) 4 OL; 3 ALLYL 3',5' DIFLUORO (1,1' BIPHENYL) 4 OL; 3 ALLYL 4 (ALLYLOXY) 3' NITRO 1,1' BIPHENYL; 3 ALLYL 4 (ALLYLOXY) 4' METHOXY 1,1' BIPHENYL; 3 ALLYL 4 METHOXY 3' NITRO 1,1' BIPHENYL; 3 ALLYL 4 METHOXY 4' (TRIFLUOROMETHYL) 1,1' BIPHENYL; 3 ALLYL 4' (TRIFLUOROMETHYL) (1,1' BIPHENYL) 4 OL; 3 ALLYL 4' FLUORO (1,1' BIPHENYL) 4 OL; 3 ALLYL 4' METHOXY (1,1' BIPHENYL) 4 OL; 3',5 DIALLYL 4' ETHOXYBIPHENYL 2 OL; 3',5 DIALLYL 4' ISOPROPOXYBIPHENYL 2 OL; 3',5 DIALLYL 4' METHOXY (1,1' BIPHENYL) 2 OL; 3',5 DIALLYL 4' PROPOXYBIPHENYL 2 OL; 3,5 DIALLYL 4' METHOXY (1,1' BIPHENYL) 4 OL; 4' METHOXY 3 (2 METHYLBUT 3 EN 2 YL) (1,1' BIPHENYL) 4 OL; 5 ALLYL (1,1' BIPHENYL) 2,4' DIOL; 5 ALLYL 2 METHOXY 3' NITRO 1,1' BIPHENYL; 5 ALLYL 2,4' DIMETHOXY 1,1' BIPHENYL; 5 ALLYL 3' NITRO (1,1' BIPHENYL) 2 OL; ANGIOGENESIS INHIBITOR; HONOKIOL; N [3' ALLYL 4' METHOXY (1,1' BIPHENYL) 3 YL] ACETAMIDE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; IC 50; MAGNOLIA OFFICINALIS; MEDICINAL PLANT; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; ZEBRA FISH;

ALLYL COMPOUNDS; ANGIOGENESIS INHIBITORS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BENZALDEHYDES; BIPHENYL COMPOUNDS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; EMBRYO, NONMAMMALIAN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; LIGNANS; MAGNOLIA; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH;

EID: 80053917269     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200830u     Document Type: Article

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