Multiparametric optical mapping of the langendorff-perfused rabbit heart

Journal of Visualized Experiments

Volumn , Issue 55, 2011, Pages

  Lou, Qing ^a   Li, Wenwen ^a   Efimov, Igor R ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Action potential; Bioengineering; Calcium dye; Calcium transient; Issue 55; Optical mapping; Rabbit heart; Voltage sensitive dye

Indexed keywords

EID: 80053915558     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/3160     Document Type: Article

References (23)

1. Efimov, I.R., Nikolski, V.P., & Salama, G. Optical imaging of the heart. Circ Res. 95, 21-33 (2004).
2. Panfilov, A.V. Is heart size a factor in ventricular fibrillation? Or how close are rabbit and human hearts? Heart Rhythm. 3, 862-864 (2006).
3. Maier, L.S., Bers, D.M., & Pieske, B. Differences in Ca(2+)-handling and sarcoplasmic reticulum Ca(2+)-content in isolated rat and rabbit myocardium. J Mol Cell Cardiol. 32, 2249-2258 (2000).
4. Bray, M.A., Lin, S.F., & Wikswo, J.P., Jr. Three-dimensional surface reconstruction and fluorescent visualization of cardiac activation. IEEE Trans Biomed Eng. 47, 1382-1391 (2000).
5. Qu, F., Ripplinger, C.M., Nikolski, V.P., Grimm, C., & Efimov, I.R. Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart. J Biomed Opt. 12, 044019 (2007).
6. Lou, Q., Ripplinger, C.M., Bayly, P.V., & Efimov, I.R. Quantitative panoramic imaging of epicardial electrical activity. Ann Biomed Eng. 36, 1649-1658 (2008).
7. Kay, M.W., Amison, P.M., & Rogers, J.M. Three-dimensional surface reconstruction and panoramic optical mapping of large hearts. IEEE Trans Biomed Eng. 51, 1219-1229 (2004).
8. Li, W., Ripplinger, C.M., Lou, Q., & Efimov, I.R. Multiple monophasic shocks improve electrotherapy of ventricular tachycardia in a rabbit model of chronic infarction. Heart Rhythm. 6, 1020-1027 (2009).
9. Ripplinger, C.M., Lou, Q., Li, W., Hadley, J., & Efimov, I.R. Panoramic imaging reveals basic mechanisms of induction and termination of ventricular tachycardia in rabbit heart with chronic infarction: implications for low-voltage cardioversion. Heart Rhythm. 6, 87-97 (2009).
10. Efimov, I.R., Rendt, J.M., & Salama, G. Optical maps of intracellular [Ca2+]i transients and action-potentials from the surface of perfused guinea-pig hearts (abstract). Circulation. 90, 632-632 (1994).
11. Choi, B.R. & Salama, G. Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: mechanisms underlying concordant alternans. J Physiol. 529 Pt 1, 171-188 (2000).
12. Fast, V.G. & Ideker, R.E. Simultaneous optical mapping of transmembrane potential and intracellular calcium in myocyte cultures. J Cardiovasc Electrophysiol. 11, 547-556 (2000).
13. Laurita, K.R. & Singal, A. Mapping action potentials and calcium transients simultaneously from the intact heart. Am J Physiol Heart Circ Physiol. 280, H2053-2060 (2001).
14. Choi, B.R., Burton, F., & Salama, G. Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol. 543, 615-631 (2002).
15. Hwang, G.S., et al. Intracellular calcium and vulnerability to fibrillation and defibrillation in Langendorff-perfused rabbit ventricles. Circulation. 114, 2595-2603 (2006).
16. Lou, Q. & Efimov, I.R. Enhanced susceptibility to alternans in a rabbit model of chronic myocardial infarction. Conf Proc IEEE Eng Med Biol Soc., 4527-4530 (2009).
17. Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun. 320, 1020-1025 (2004).
18. Bray, M.A. & Wikswo, J.P. Considerations in phase plane analysis for nonstationary reentrant cardiac behavior. Phys Rev E Stat Nonlin Soft Matter Phys. 65, 051902 (2002).
19. Fast, V. Recording action potentials using voltage-sensitive dyes. Practical methods in cardiovascular research. 233-255 (2005).
20. Knisley, S.B. Transmembrane voltage changes during unipolar stimulation of rabbit ventricle. Circ Res. 77, 1229-1239 (1995).
21. Bishop, M.J., et al. The role of photon scattering in optical signal distortion during arrhythmia and defibrillation. Biophys J. 93, 3714-3726 (2007).
22. Efimov, I.R., Fedorov, V.V., Joung, B., & Lin, S.F. Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping. Circ Res. 106, 255-271 (2010).
23. Fedorov, V.V., et al. Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts. Heart Rhythm. 4, 619-626 (2007).