Cytotoxic and genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells in vitro

Arhiv za Higijenu Rada i Toksikologiju

Volumn 62, Issue 3, 2011, Pages 221-227

  Durgo, Ksenija ^a   Halec, Ivana ^a   Šola, Ivana ^b   Franekić, Jasna ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

chelates; DNA damage; flavonoid metal complexes; oxidative damage

Indexed keywords

DOUBLE STRANDED DNA; LANTHANUM; QUERCETIN; SINGLE STRANDED DNA;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; DNA DAMAGE; DOSE RESPONSE; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG EXPOSURE; FEMALE; GENOTOXICITY; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; OXIDATIVE STRESS; SINGLE STRANDED DNA BREAK; UTERINE CERVIX CARCINOMA;

ANTIOXIDANTS; CELL SURVIVAL; COMET ASSAY; DNA BREAKS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LANTHANUM; LIPID PEROXIDATION; QUERCETIN; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 80053654810     PISSN: 00041254     EISSN: None     Source Type: Journal    
DOI: 10.2478/10004-1254-62-2011-2122     Document Type: Article

References (25)

1. Wang B, Yang Z-Y, Wang Q, Cai T, Crewdson P. Synthesis, characterization, cytotoxic activities and DNA binding properties of the La(III) complex with naringenin Schiff-base. Bioorg Med Chem 2006;14:1880-8. (Pubitemid 43199520)
2. Day Y, Li J, Li J, Yu L, Dai G, Hu A, Yuan L, Wen Z. Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In vitro Cell Dev Biol Anim 2002;38:373-5. (Pubitemid 36150672)
3. Zhang Z, Wang J, Li J, Xu S. Telomerase-mediated apoptosis of chicken lymphoblastoid tumor cell line by lanthanum chloride. Biol Trace Elem Res 2011. DOI: 10.1007/s12011- 011-9027-8
4. Kovacic P, Popp WJ, Ames JR, Ryan MD. Anti-cancer action of metal complexes:electron transfer and oxidative stress? Anticancer Drug Des 1988;3:205-16. (Pubitemid 19025686)
5. Kostova I, Momekov G, Zaharieva M, Karaivanova M. Cytotoxic activity of new lanthanum (III) complexes of biscoumarins. Eur J Med Chem 2005;40:542-51. (Pubitemid 40732523)
6. Brabec V, Novakova O. DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resist Updat 2006;9;111-22. (Pubitemid 44279519)
7. Kleemann R, Verschuren L, Morrison M, Zadelaar S, van Erk MJ, Wielinga PY, Kooistra T. Anti-inflammatory, antiproliferative and anti-atheroschlerotic effects of quercetin in human in vitro and in vivo models. Atheroschlerosis 2011;218:44-52.
8. Durgo K, Vukovic L, Rusak G, Osmak M, Franekic Colic J. Effect of flavonoids on glutathione level, lipid peroxidation and cytochrome P450 CYP1A1 expression in human laryngeal carcinoma cell lines. Food Technol Biotechnol 2007;45:69-79.
9. Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000;63:1035-42.
10. Boots AW, Balik JM, Bast A, Haenen GRMM. The reversibility of the glutathionyl-quercetin adduct spreads oxidised quercetin-induced toxicity. Biochem Biophys Res Commun 2005;338:923-9. (Pubitemid 41597730)
11. van der Woude H, Gliszczynska-Swiglo A, Struijs K, Smeets A, Alink GM, Rietjens IMCM. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 2003;200:41-7. (Pubitemid 37222357)
12. Marinic M, Piantanida I, Rusak G, Žinic M. Interactions of quercetin and its lanthane complex with double stranded DNA/RNA and single stranded RNA. Spectrophotometric sensing of poly G. J Inorg Biochem 2006;100:288-98. (Pubitemid 43084748)
13. Cemažar M, Marolt D, Lavric M, Serša G. Comparison of colorimetric MTT and clonogenic assays for irradiation and cisplatin treatment on murine fi brosarcoma SA-1 cells. Radiol Oncol 1999;33:303-8.
14. Matsuo M, Sasaki N, Saga K, Kaneko T. Cytotoxicty of flavonoids toward cultured normal human cells. Biol Pharm Bull 2005;28:253-9. (Pubitemid 40880004)
15. Cereser C, Boget S, Parvaz P, Revol A. Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death. Toxicology 2001;163:153-62. (Pubitemid 32539287)
16. McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S. Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water soluble Coenzyme Q-10. Toxicol Appl Pharmacol 2004;201:21-31. (Pubitemid 39446323)
17. Bradford MM. A rapid and sensitive method for the quantifi cation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
18. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91.
19. Rusak G, Piantanida I, Mašic L, Kapuralin K, Durgo K, Kopjar N. Spectrophotometric analysis of flavonoid-DNA interactions and DNA damaging/protecting and cytotoxic potential of flavonoids in human peripheral blood lymphocytes. Chem-Biol Interact 2010;188:181-9.
20. Durgo K, Kostic S, Gradiški K, Komes D, Osmak M, Franekic J. Genotoxic effects of green tea extract on human laryngeal carcinoma cells in vitro. Arh Hig Rada Toksikol 2011:62:139-46.
21. Plochmann K, Korte G, Koutsilieri E, Richling E, Riederer P, Rethwilm A, Schreier P, Scheller P. Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells. Arch Biochem Biophys 2007;460:1-9. (Pubitemid 46482429)
22. Durgo K, Vukovic L, Rusak G, Osmak M, Franekic Colic J. Cytotoxic and apoptotic effect of structurally similar flavonoids on parental and drug-resistant cells of a human cervical carcinoma. Food Technol Biotechnol 2009;47:323-30.
23. Sergediene E, Jonsson K, Szymusiak H, Tyrakowska B, Rietjens IMCM, Cenas N. Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships. FEBS Lett 1999;462:392-6.
24. Walle T. Serial Review: Flavonoids and isoflavones (phytoestrogenes): absorption, metabolism and bioactivity: absorption and metabolism of flavonoids. Free Radic Biol Med 2004;36:829-37.
25. Gutzeit HO, Henker Y, Kind B, Franz A. Specifi c interactions of quercetin and other flavonoids with target proteins are revealed by elicited fluorescence. Biochem Biophys Res Comm 2004;318:490-5. (Pubitemid 38553806)