How porphyrinogenic drugs modeling acute porphyria impair the hormonal status that regulates glucose metabolism. Their relevance in the onset of this disease

Toxicology

Volumn 290, Issue 1, 2011, Pages 22-30

  Matkovic, Laura B ^a   D'Andrea, Florencia ^a   Fornes, Daiana ^a   San Martín de Viale, Leonor C ^a   Mazzetti, Marta B ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Acute porphyria model; Glucocorticoids; Glycogen phosphorylase; Insulin; Phosphoenolpyruvate carboxykinase; UDP glucuronosyltransferase

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER; 5 AMINOLEVULINATE SYNTHASE; ALLYLISOPROPYLACETAMIDE; CARBOHYDRATE; CORTICOSTERONE; CORTICOTROPIN; GLUCOCORTICOID; GLUCOSE; GLUCURONOSYLTRANSFERASE; GLYCOGEN PHOSPHORYLASE; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PORPHYRINOGEN; PYRUVATE KINASE;

ACUTE INTERMITTENT PORPHYRIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; CORTICOSTERONE RELEASE; DISEASE MODEL; ENZYME ACTIVITY; FEMALE; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLYCOGENOLYSIS; INSULIN BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CORTICOSTERONE; DISEASE MODELS, ANIMAL; FEMALE; GLUCOSE; PORPHYRIA, ACUTE INTERMITTENT; PORPHYRINOGENS; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 80053652867     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.08.014     Document Type: Article

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