Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus

Lupus

Volumn 20, Issue 12, 2011, Pages 1300-1304

  Freutel, S ^a   Gaffal, E ^a   Zahn, S ^a   Bieber, T ^a   Tuting T ^a   Wenzel, J ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

cutaneous lupus; discoid lupus; subacute lupus

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; MYXOVIRUS RESISTANCE PROTEIN A;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE MARKER; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN DEFECT; SKIN LUPUS ERYTHEMATOSUS; TH1 CELL; TH1 TH2 BALANCE;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; GTP-BINDING PROTEINS; HUMANS; INTERFERON-ALPHA; LUPUS ERYTHEMATOSUS, CUTANEOUS; LUPUS ERYTHEMATOSUS, DISCOID; MALE; MIDDLE AGED; RECEPTORS, CCR3; RECEPTORS, CCR5; TH1 CELLS; TH2 CELLS; YOUNG ADULT;

EID: 80053629082     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203311409267     Document Type: Article

References (14)

1. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized Thelper 1 and 2 lymphocytes. J Exp Med. 1998 ; 187: 875-883 (Pubitemid 28141661)
2. Yates A, Callard R, Stark J. Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making. J Theor Biol. 2004 ; 231: 181-196 (Pubitemid 39221871)
3. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994 ; 76: 301-314 (Pubitemid 24046692)
4. Austrup F, Vestweber D, Borges E. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature. 1997 ; 385: 81-83 (Pubitemid 27024558)
5. Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science. 1997 ; 277: 2005-2007 (Pubitemid 27449145)
6. Wenzel J, Wörenkämper E, Freutel S, et al. Enhanced type I interferon signaling promotes a Th1 biased inflammation in cutaneous lupus erythematosus. J Pathol. 2005 ; 205: 435-442 (Pubitemid 40361331)
7. Rogge L, Barberis-Maino L, Biffi M. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. JExp Med. 1997 ; 185: 825-831 (Pubitemid 27119866)
8. Wenzel J, Henze S, Brahler S, Bieber T, Tuting T. The expression of human leukocyte antigen-DR and CD25 on circulating T cells in cutaneous lupus erythematosus and correlation with disease activity. Exp Dermatol. 2005 ; 14: 454-459 (Pubitemid 40740397)
9. al-Masri AN, Werfel T, Jakschies D, von Wussow P. Intracellular staining of Mx proteins in cells from peripheral blood, bone marrow and skin. Mol Pathol. 1997 ; 50: 9-14
10. Farkas L, Beiske K, Lund-Johansen F, Brandtzaeg P, Jahnsen FL. Plasmacytoid dendritic cells (natural interferon-alpha/beta-producingcells) accumulate in cutaneous lupus erythematosus lesions. Am J Pathol. 2001 ; 159: 237-243 (Pubitemid 33704208)
11. Yang YF, Tomura M, Iwasaki M. IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells. J Clin Immunol. 2001 ; 21: 402-409 (Pubitemid 34017074)
12. Loetscher P, Pellegrino A, Gong JH. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 ; 276: 2986-2991
13. Gomez D, Correa PA, Gomez LM, Cadena J, Molina JF, Anaya JM. Th1/Th2 cytokines in patients with systemic lupus erythematosus: is tumor necrosis factor alpha protective?. Semin Arthritis Rheum. 2004 ; 33: 404-413 (Pubitemid 38887139)
14. Eriksson C, Eneslatt K, Ivanoff J, Rantapaa-Dahlqvist S, Sundqvist KG. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus. Lupus. 2003 ; 12: 766-774 (Pubitemid 37295812)