Oxidative stress in primary open-angle glaucoma

Frontiers in Bioscience - Elite

Volumn 3 E, Issue 4, 2011, Pages 1524-1533

  Erb, Carl ^a   Heinke, Melanie ^a  

^a Schlosspark Klinik   (Germany)

Author keywords

Glaucoma; NF B; Oxidative stress; Review; Trabecular meshwork

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MELATONIN; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE; VISUAL PIGMENT;

AGING; ANTERIOR EYE CHAMBER; AQUEOUS HUMOR; ARTICLE; HUMAN; IMMUNOPATHOLOGY; INTRAOCULAR PRESSURE; LIPID PEROXIDATION; OPEN ANGLE GLAUCOMA; OPTIC DISK; OPTIC NERVE DISEASE; OXIDATIVE STRESS; PATHOGENESIS; PIGMENT EPITHELIUM; POSTERIOR EYE CHAMBER; SYSTEMIC DISEASE; TRABECULAR MESHWORK; METABOLISM;

GLAUCOMA, OPEN-ANGLE; HUMANS; OXIDATIVE STRESS;

EID: 80053617415     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e353     Document Type: Article

References (125)

1. H Sies: Oxidative stress: oxidants and antioxidans. London: Academic Press (1991).
2. DP Jones: Disruption of mitochondrial redox circuitry in oxidative stress. Chem Biol Interact, 163:38-53 (2006). (Pubitemid 44572221)
3. A Spector, WH Garner: Hydrogen peroxide and human cataract. Exp Eye Res 33:673-681 (1981). (Pubitemid 12253597)
4. GR Reiss, DA Lee, JE Topper, RF Brubacker: Aqueous humor flow during sleep. Invest Ophthalmol Vis Sci, 25:776-778 (1984). (Pubitemid 14082992)
5. +-ascorbate cotransport in cultured bovine pigmented ciliary epithelial cells. Cell Physiol 25:C440-C49 (1989).
6. A Ringvold: The significance of ascorbate in the aqueous humour protection against UV-A and UV-B. Exp Eye Res 62:261-264 (1996). (Pubitemid 26128001)
7. C Erb, K Nau-Staudt, J Flammer, W Nau: Ascorbic acid as a free radical scavenger in porcine and bovine aqueous humour. Ophthalmic Res 36:38-42 (2004). (Pubitemid 38328008)
8. SL Fishbein, S Goodstein: The pressure lowering effect of ascorbic acid. Ann Ophthalmol 4:487-491 (1972).
9. E Linner: The pressure lowering effect of ascorbic acid in ocular hypertension. Acta Ophthalmol (Copenh) 47:685-689 (1969).
10. TM Shen, MC Yu: Clinical evaluation of glycerinesodium ascorbate solution in lowering intraocular pressure. Chin Med J (Engl) 1:64-68 (1975).
11. AT Aleksidze, IN Beradze, OG Golovachev: Effect of the ascorbic acid of the aqueous humor on the lipid peroxidation process in the eye in primary open-angle glaucoma. Oftalmol Zh 2:114-116 (1989).
12. KM Liu, D Swann, P Lee, KW Lam: Inhibition of oxidative degradation of hyaluronic acid by uric acid. Curr Eye Res 3:1049-1053 (1984). (Pubitemid 14030479)
13. DO Schachtschabel, E Binninger: Stimulatory effects of ascorbic acid on hyaluronic acid synthesis of in vitro cultured normal and glaucomatous trabecular meshwork cells of the human eye. Z Gerontol 26:243-246 (1993). (Pubitemid 23336905)
14. E Higginbotham, BY Yue, E Crean, J Peace:. Effects of ascorbic acid on trabecular meshwork cells in culture. Exp Eye Res 46:507-516 (1988).
15. SP Richter, RC Rose: Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide. Vision Res 38:2881-2888 (1998). (Pubitemid 28403145)
16. MV Riley, RF Meyer, EM Yates: Glutathione in the aqueous humor of human and other species. Invest Ophthalmol Vis Sci 19:94-6 (1980). (Pubitemid 10160468)
17. AP Costarides, MV Riley, K Green: Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen peroxide. Ophthalmic Res 23:284-294 (1991).
18. C Costagliola, G Iuliano, M Menzione, E Rinaldi, P Vito, G Auricchio: Effect of vitamin E on glutathione content in red blood cells, aqueous humor and lens of humans and other species. Exp Eye Res 43:905-914 (1986). (Pubitemid 17231170)
19. KC Bhuyan, DK Bhuyan: Regulation of hydrogen peroxide in eye humors. Effect of 3-amino-1H-1, 2, 4-triazole on catalase and glutathione peroxidase of rabbit eye. Biochem Biophys Acta 497:641-651 (1977). (Pubitemid 8104439)
20. KC Bhuyan, DK Bhuyan: Superoxide dismutase of the eye: relative functions of superoxide dismutase and catalase in protecting the ocular lens from oxidative damage. Biochem Biophys Acta 542:28-38 (1978). (Pubitemid 8394745)
21. SF Freedman, PJ Anderson, DL Epstein: Superoxide dismutase and catalase of calf trabecular meshwork. Invest Ophthalmol Vis Sci 26:1330-5 (1985). (Pubitemid 15241055)
22. RC Rose, SP Richer, AM Bode: Ocular oxidants and antioxidant protection. Proc Soc Exp Biol Med 217:397-407 (1998).
23. MG Kahn, FJ Giblin, DL Epstein: Gluthatione in calf trabecular meshwork and its relation to aqueous humor outflow facility. Invest Ophthalmol Vis Sci 24:1283-1287 (1983). (Pubitemid 13006625)
24. RF Brubacker: Flow of aqueous humor in humans [The Friedenwald Lecture]. Invest Ophthalmol Vis Sci 32:3145-66 (1991).
25. S Altimari, T Mascaro, S Leopardi, L Zompatori, A Missiroli, EM Vingolo: Age-related correlation between ascorbic acid in aqueous humor and serum. Invest Ophthalmol Vis Sci ARVO-Abstract Nr. 3952 (2007).
26. MA De La Paz, DL Epstein: Effect of age on superoxide dismutase activity of human trabecular meshwork. Invest Ophthalmol Vis Sci. 37:1849-53 (1996). (Pubitemid 26265035)
27. JA Vinson: Oxidative stress in cataracts. Pathophysiology 13:151-162 (2006). (Pubitemid 44026670)
28. JW Rohen, E Lütjen: On the age-dependent changes of the trabecular meshwork in the human eye. Graefes Arch Clin Exp Ophthalmol 175:285-307 (1968).
29. BT Gabelt, PL Kaufmann: Changes in aqueous humor dynamics with age and glaucoma. Prog Ret Eye Res 24:612-637 (2005). (Pubitemid 40943663)
30. BEK Klein, R Klein, KLP Lointon: Intraocular pressure in an American community. The Beaver Dam eye study. Invest Ophthalmol Vis Sci 33:2224-2228 (1992).
31. KK Abu-Amero, J Morales, TM Bosley: Mitochondrial abnormalities in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 47:2533-2541 (2006). (Pubitemid 351639838)
32. SM Ferreira, SF Lerner, R Brunzini, PA Evelson, SF Llesuy: Oxidative stress markers in aqueous humour of glaucoma patients. Am J Ophthalmol 137:62-69 (2004). (Pubitemid 38045188)
33. AI Bunin, AA Filina, VP Erichev: A glutathione deficiency in open-angle glaucoma and the approaches to its correction. Vestn Oftalmol 108:13-15 (1992). (Pubitemid 23061188)
34. MA Babizhayev, A Bunin: Lipid peroxidation in openangle glaucoma. Acta Ophthalmol (Copenh) 67:371-377 (1989).
35. NI Kurysheva, MI Vinetskaia, VP Erichev, VP Artamonov, AP Uspenskaia: Contribution of free-radical reactions of chamber humor to the development of primari open-angle glaucoma. Vestn Oftalmol 112:3-5 (1996).
36. JI Kourie: Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol 275:C1-C24 (1998). (Pubitemid 28381298)
37. IL Chang, G. Elner, Y. J. Yue, A. Cornicelli, J. E. Kawa, V. M. Elner: Expression of modified low-density lipoprotein receptors by trabecular meshwork cells. Curr Eye Res 10:1101-1112 (1991).
38. CY Song, BC Kim, HK Hong, HS Lee: Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-beta signalling in mesangial cells. Kidney Int 67:1743-1752 (2005).
39. MW Meyer, M Von Depka, C Wilhelm, A Schröder, C Erb: Plasminogen activator inhibitor-1 mRNA expression in cultured pigmented ciliary epithelial cells of the porcine eye. Graefes Arch Clin Exp Ophthalmol 240:679-86 (2002). (Pubitemid 36075630)
40. J Dan, D Belyea, G Gertner, I Leshem, M Lusky, R Miskin: Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma. Arch Ophthalmol 123:220-4 (2005). (Pubitemid 40189710)
41. M Birke, C Neumann, U Welge-Lüßen, A Yu, E Lütjen-Drecoll: Effect of TGF-ß2 on elastin expression and components of the proteolytic system in human optic nerve head astrocytes. Invest Ophthalmol Vis Sci ARVO-abstract 3660 (2007).
42. SE Ohia, CA Opere, AM Le Day: Pharmacological consequences of oxidative stress in ocular tissues. Mutation Res 579:22-36 (2005). (Pubitemid 41540130)
43. L Zhou, Y Li, BY Yue: Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork. J Cell Physiol 180:182-189 (1999). (Pubitemid 29297195)
44. N Wang, SK Chintala, ME Fini, JS Schuman: Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nature Medicine 7:304-309 (2001). (Pubitemid 32224345)
45. A Izzotti, SC Sacca, C Cartiglia, S De Flora: Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am J Med 114:638-46 (2003). (Pubitemid 36703232)
46. SC Sacca, A Pascotto, P Camicione, P Capris, A Izzotti: Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. Arch Ophthalmol 123:458-463 (2005). (Pubitemid 40489915)
47. A Izzotti, A Bagnis, SC Saccà: The role of oxidative stress in glaucoma. Mutation Research 612:105-114 (2006). (Pubitemid 43222096)
48. J Veach: Functional dichotomy: glutathione and vitamin E in homeostasis relevant to primary open-angle glaucoma. Br J Nutrition 91:809-829 (2004). (Pubitemid 38931445)
49. C Debbasch, F Brignole, PJ Pisella, JM Warnet, P Rat, C Baudouin: Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells. Invest Ophthalmol Vis Sci 42:642-52 (2001). (Pubitemid 32206903)
50. P Hamard, C Blondin, C Debbasch, JM Warnet, C Baudouin, F Brignole: In vitro effects of preserved and unpreserved antiglaucoma drugs on apoptotic marker expression by human trabecular cells. Graefes Arch Clin Exp Ophthalmol 241:1037-43 (2003). (Pubitemid 38028900)
51. M Rozanowska, J Jarvis-Evans, W Korytowski, M Boulton, JM Burke, T Sarna: Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygenreactive species. J Biol Chem 270:18825-30 (1995).
52. NN Osborne, G Lascaratos, AJ Bron, G Chidlow, JPM Wood: A hypothesis to suggest that light is a risk factor in glaucoma and the mitochondrial optic neuropathies. Br J Ophthalmol 90:237-241 (2006). (Pubitemid 43163859)
53. W Sickel: Retinal metabolism in dark and light. In: Handbook of sensory physiology. Ed: MHF Fuortes. Berlin. Springer-Verlag: 667-727 (1972).
54. N. G. Bazan: The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology. Prog Clin Biol Res 312:95-112 (1989).
55. DJjr Tate, MV Miceli, DA Newsome: Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 36:1271-9 (1995).
56. X Zhang, C Erb, J Flammer, WM Nau: Absolute rate constants for the quenching of reactive excited states by melanin and related 5, 6-dihydroxyindole metabolites: implications for their antioxidant activity. Photochem Photobiol 71:524-33 (2000).
57. W Schalch: Carotenoids in the retina - a review of their possible role in preventing or limiting damage caused by light and oxygen. EXS 62:280-98 (1992).
58. PO Lundmark, SR Pandi-Perumal, V Srinivasan, DP Cardinali: Role of melatonin in the eye and ocular dysfunctions. Vis Neurosci 23:853-862 (2006). (Pubitemid 46456691)
59. P Alarma-Estrany, J Pintor: Melatonin receptors in the eye: location, second messengers and role in ocular physiology. Pharmacol Ther 113:507-522 (2007) (Pubitemid 46365956)
60. RJ Reiter, DX Tan, JC Mayo, RM Sainz, J Leon, Z Czarnocki: Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochem Pol 50:1129-1146 (2003). (Pubitemid 38608841)
61. E Ganea, JJ Harding: Glutathione-related enzymes and the eye. Curr Eye Res 31:1-11 (2006). (Pubitemid 43155539)
62. PA Friedman, ML Zeidel: Victory at C. Nat Med 5:620-1 (1999). (Pubitemid 29289422)
63. BJ Woodfort, MO Tso, KW Lam: Reduced and oxidized ascorbates in guinea pig retina under normal and light-exposed conditions. Invest Ophthalmol Vis Sci 24:862-7 (1983). (Pubitemid 13036939)
64. A Heckelen, M Hermel, B Kondring, NF Schrage: Ascorbic acid reversibly inhibits proliferation of retinal pigment epithelial cells. Acta Ophthalmol Scand 82:564-568 (2004). (Pubitemid 39386969)
65. DM Snodderly: Evidence for protection against agerelated macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 62(Suppl):1448S-1461S (1995).
66. NA Rao, G Thael, JM Delmage, A Sevanian: Superoxide dismutase in ocular structures. Invest Ophthalmol Vis Sci 26:1778-1781 (1985). (Pubitemid 16172117)
67. SY Schmidt, RD Peisch: Melanin concentration in normal retinal pigment epithelium. Regional variation and age-related reduction. Invest Ophthalmol Vis Sci 27:1063-1067 (1986). (Pubitemid 16062042)
68. AJ Whitehead, JA Mares, RP Danis: Macular Pigment. A review of current knowledge. Arch Ophthalmol 124:1038-1045 (2006). (Pubitemid 44036329)
69. M Boulton, M Rózanowska, B Rózanowski, T Wess: The photoreactivity of ocular lipofuscin. Photochem Photobiol Sci 3:759-764 (2004). (Pubitemid 39302976)
70. FA Shamsi, M Boulton: Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin. Invest Ophthalmol Vis Sci 42:3041-6 (2001). (Pubitemid 33035307)
71. PJ Thornalley: Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Cell Mol Biol 44:1013-1023 (1998).
72. Y Yamada, K Ishibashi, IA Bhutto, J Tian, GA Lutty, JT Handa: The expression of advanced glycation endproduct receptors in RPE cells associated with basal deposits in human maculas. Exp Eye Res 82:840-848 (2006). (Pubitemid 43170884)
73. F Reber, M Kasper, A Siegner, E Kniep, G Seigel, RH Funk: Alteration of the intracellular pH and apoptosis induction in a retinal cell line by the AGE-inducing agent glyoxal. Graefes Arch Clin Exp Ophthalmol 240:1022-1032 (2002). (Pubitemid 36097664)
74. J Albon, WS Karwatowski, DL Easty, TJ Sims, VC Duance: Age related changes in the non-collagenous components of the extracellular matrix of the human lamina cribrosa. Br J Ophthalmol 84:311-7 (2000). (Pubitemid 30251689)
75. J Albon, PP Purslow, WS Karwatowski, DL Easty: Age related compliance of the lamina cribrosa in human eyes. Br J Ophthalmol 84:318-23 (2000). (Pubitemid 30251690)
76. J Albon, WS Karwatowski, N Avery, DL Easty, VC Duance: Changes in the collagenous matrix of the aging human lamina cribrosa. Br J Ophthalmol 79:368-75 (1995).
77. MC Moreno, J Campanelli, P Sande, DA Sanez, MI Keller Sarmiento, RE Rosenstein: Retinal oxidative stress induced by high intraocular pressure. Free Radical Biol Med 37:803-12 (2004). (Pubitemid 39078552)
78. B Liu, B Neufeld: Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro. Arch Ophthalmol 119:240-5 (2001). (Pubitemid 32147932)
79. L Yuan, AH Neufeld: Activated microglia in the human glaucomatous optic nerve head. J Neurosci Res 64:523-32 (2001). (Pubitemid 32521772)
80. C Maihöfner, U Schlötzer-Schrehardt, H Gühring, HU Zeilhofer, GOH. Naumann, A Pahl, C Mardin, ER Tamm, K Brune: Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes. Invest Ophthalmol Vis Sci 42:2616-2624 (2001). (Pubitemid 32954872)
81. G Tezel, LY Li, RV Patil, MB Wax: TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes. Invest Ophthalmol Vis Sci 42:1787-1794 (2001). (Pubitemid 32652354)
82. OA. Agapova, CS Ricard, M Salvador-Silva, MR Hernandez: Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia 33:205-216 (2001). (Pubitemid 32219129)
83. AG Böhm, E Spörl: Neue biomechanische Aspekte zur Bedeutung der Lamina cribrosa und der peripapillären Sklera beim Glaukom. In: Search on Glaukom: Chronobiologie und Chronopharmakologie beim Glaukom. Ed: C Erb. Amsterdam, Excerpta Medica: 52-60 (2006).
84. RC Tripathi, J Li, WF Chan, BJ Tripathi: Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp Eye Res 59:723-727 (1994).
85. R Fuchshofer, M Birke, U Welge-Lüssen, D Kook, E Lütjen-Drecoll: Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes. Invest Ophthalmol Vis Sci 46:568-78 (2005). (Pubitemid 40270337)
86. J Gottanka, D Chan, M Eichhorn, E Lütjen-Drecoll, CR Ethier: Effects of TGF-ß2 in perfused human eyes. Invest Ophthalmol Vis Sci 45:153-158 (2004). (Pubitemid 38055681)
87. R Fuchshofer: The pathogenic role of transforming growth factor-ß2 in glaucomatous damage to the optic nerve head. Exp Eye Res [Epub ahead in print] (2010).
88. K Yao, J Tan, WZ Gu, PP Ye, KJ Wang: Reactive oxygen species mediates the apoptosis induced by transforming growth factor beta (2) in human lens epithelial cells. Biochem Biophys Res Commun 354:278-83 (2007). (Pubitemid 46123231)
89. D Gherghel, HR Griffiths, EJ Hilton, IA Cunliffe, SL Hosking: Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 46:877-83 (2005). (Pubitemid 41321023)
90. O Yildirim, NA Ates, B Ercan, N Muslu, A Unlu, L Tamer, U Atik: Role of oxidative stress enzymes in openangle glaucoma. Eye 19:580-583 (2005). (Pubitemid 40711715)
91. ER Asregadoo: Blood levels of thiamine and ascorbic acid in chronic open angle glaucoma. Ann Ophthalmol 11:1095-1100 (1979). (Pubitemid 9224774)
92. GO Sperber, A Bill: Blood flow and glucose consumption in the optic nerve, retina and brain: effects of high intraocular pressure. Exp Eye Res 41:639-53 (1985). (Pubitemid 16177624)
93. M Elisaf, G Kitsos, E Bairaktari, R Kalaitzidis, C Kalogeropoulos, K Psilas: Metabolic abnormalities in patients with primary open-angle glaucoma. Acta Ophthalmol Scand 79:129-132 (2001). (Pubitemid 32258182)
94. A Heijl, MC Leske, B Bengtsson, L Hyman, B Bengtsson, M Hussein, Early Manifest Glaucoma Trial Group: Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120:1268-1279 (2002). (Pubitemid 36105431)
95. C Erb: Importance of the nuclear factor kappaB for the primary open angle glaucoma - a hypothesis. Klin Monatsbl Augenheilkd 227:120-127 (2010).
96. U Welge-Lüßen, K Birke: Oxidative stress in the trabecular meshwork of POAG. Klin Monatsbl Augenheilkd 227:99-107 (2010).
97. FH Grus: Relationship between oxidative stress and autoimmunity in glaucoma. Klin Monatsbl Augenheilkd 227:114-119 (2010).
98. J Flammer, IO Haefliger, S Orgül: Vascular dysregulation: a principal risk factor for glaucomatous damage ? J Glaucoma 8:212-219 (1999). (Pubitemid 32435883)
99. D Moore, A Harris, D Wu Dunn, N Kheradiya, B Siesky: Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma? Clin Ophthalmol 2:849-861 (2008).
100. MC Leske, A Heijl, L Hyman, B Bengtsson, L Dong, Z Yang, EMGT Group: Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 114:1965-1972 (2007). (Pubitemid 350016362)
101. BC Chauhan, FS Mikelberg, AG Balaszi, RP Le Blanc, MR Lesk, GE Trope, Canadian Glaucoma Study Group: Canadian Glaucoma Study: 2. risk factors for the progression of open angle glaucoma. Arch Ophthalmol 126:1030-1036 (2008).
102. HA Hadi, JA Suwaidi: Endothelial dysfunction in diabetes mellitus. Vasc Health Risk Manag 3:853-876 (2007).
103. P Rösen, Ch Bellin: Diabetes und oxidativer Stress. Blickpunkt der Mann 2:23-30 (2004).
104. S Neri, S Signorelli, D Pulvirentil: Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. Free Radic Res 40:615-618 (2006). (Pubitemid 43832516)
105. G Yilmaz, H Sürer, LE Inan, Ö Coskun, D Yücel: Increased nitrosative and oxidative stress in platelets of migraine patients. Tohoku J Exp Med 211:23-30 (2007). (Pubitemid 46062216)
106. GE Tietjen: Migraine as a systemic vasculopathy. Cephalalgia 29:987-996 (2009).
107. WK Ju, KY Kim, JD Lindsey, M Angert, KX Duong-Polk, RT Scott, JJ Kim, I Kukhmazov, MH Ellisman, GA Perkins, RN Weinreb: Intraocular Pressure Elevation Induces Mitochondrial Fission and Triggers OPA1 Release in Glaucomatous Optic Nerve. Invest Ophthalmol Vis Sci 49:4903-11 (2008).
108. A Izzotti, A Bagnis, SC Saccà: The role of oxidative stress in glaucoma. Mutation Research 612:105-114 (2006). (Pubitemid 43222096)
109. E Hasnis, M Bar-Shai, Z Burbea, AZ Reznick: Mechanisms underlyind cigarette smoke-induced NF-kappaB activation in human lymphocytes: the role of reactive nitrogen species. J Physiol Pharmacol 58(Suppl 5):275-287 (2007). (Pubitemid 351346674)
110. J Flammer: Die Rolle der Reperfusion in der Induktion der Apoptose. In: Neuronale Konzepte beim Glaukom. Eds: Erb C, Arend O. Uni-Med, Bremen: 68-70 (2005).
111. LH Toledo-Pereyra, AH Toledo, J Walsh, F Lopez-Neblina: Molecular signaling pathways in ischemia/reperfusion. Exp Clin Transplant 2:174-177 (2004).
112. J Kountouras, C Zavos, N Grigoriadis, G Deretzi, P Katsinelos, D Tzilves: Helicobacter pylori infection as an environmental familial clustering risk factor for primary open-angle glaucoma. Clin Experiment Ophthalmol 36:296-7 (2008). (Pubitemid 351560285)
113. A Saha, CE Hammond, M Trojanowska, AJ Smolka: Helicobacter pylori-induced H, K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. Am J Physiol Gastrointest Liver Physiol 294:G795-807 (2008). (Pubitemid 351468758)
114. CY Wang, YC Shen, FY Lo, CH Su, SH Lee, KH Lin, HY Tsai, NW Kuo, SS Fan: Polymorphism in the IL-1alpha (889) locus associated with elevated risk of primary open angle glaucoma. Mol Vis 12:1380-1385 (2006).
115. S Yoneda, H Tanihara, N Kido, Y Honda, W Goto, H Hara, N Miyawaki: Interleukin-1beta mediates ischemic injury in the rat retina. Exp Eye Res 73:661-667 (2001). (Pubitemid 34014394)
116. Z Sun, R Anderson: NF-kB activation and inhibition: a review. Shock 18:99-106 (2002).
117. M Ohkita, M Takaoka, Y Matsumura: Endothelin-1 production and its involvement in cardiovascular diseases. Yakugaku Zasshi 127:1319-1329 (2007). (Pubitemid 47360735)
118. BC Chauhan: Endothelin and its potential role in glaucoma. Can J Ophthalmol 43:356-360 (2008).
119. S Bonello, C Zähringer, RS Bel Aiba, T Djordjevic, J Hess, C Michiels, T Kietzmann, A Görlach: Reactive oxygen species activate the HIV-1alpha promoter via a functional NF-kB site. Arterioscler Thromb Vasc Biol 27:755-761 (2007). (Pubitemid 46606703)
120. G Tezel, MB Wax: Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch Ophthalmol 122:1348-1356 (2004). (Pubitemid 39180857)
121. L Zhou, Y Li, BY Yue: Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork. J Cell Physiol 180:182-189 (1999). (Pubitemid 29297195)
122. X Zhou, F Li, L Kong, H Tomita, C Li, W Cao: Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chemistry 280:31240-31248 (2005). (Pubitemid 41291861)
123. J Yang, P Yang, G Tezel, RV Patil, MR Hernandez, MB Wax: Induction of HLA-DR expression in human lamina cribrosa astrozytes by cytokines and simulated ischemia. Invest Ophthalmol Vis Sci 42:365-371 (2001). (Pubitemid 32121465)
124. Y Zhong, CK Leung, CP Pang: Glial cells and glaucomatous neuropathy. Chin Med J 120:326-335 (2007). (Pubitemid 46403484)
125. MB Wax, G Tezel, I Saito: Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal pressure glaucoma. Am J Ophthalmol 125:145-157 (1998). (Pubitemid 28081291)