Lean non-alcoholic fatty liver disease (Lean-NAFLD): A major cause of cryptogenic liver disease

Acta Gastro-Enterologica Belgica

Volumn 74, Issue 3, 2011, Pages 389-394

  Vos, Bertrand ^a   Moreno, Christophe ^a   Nagy, Nathalie ^a   Féry, Françoise ^a   Cnop, Miriam ^a   Vereerstraeten, Pierre ^a   Devière, Jacques ^a   Adler, Michael ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

Diabetes; Non alcoholic fatty liver disease; Obesity

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; LEAN NONALCOHOLIC FATTY LIVER; LIVER BIOPSY; LIVER DISEASE; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ADULT; AGED; BIOPSY; BODY WEIGHT; FATTY LIVER; FEMALE; HEPATITIS, CHRONIC; HUMANS; LIVER; MALE; MIDDLE AGED;

EID: 80053603492     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. CLARK J.M., BRANCATI F.L., DIEHL A.M. Nonalcoholic fatty liver disease. Gastroenterology, 2002, 122: 1649-1657.
2. POWELL E.E., COOKSLEY W.G., HANSON R., SEARLE J., HALLIDAY J.W., POWELL L.W. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology, 1990, 11: 74-80.
3. ADLER M., SCHAFFNER F. Fatty liver hepatitis and cirrhosis in obese patients. Am. J. Med., 1979, 67: 811-816.
4. BROWNING J., SZCZEPANIAK L., DOBBINS R., NUREMBERG P., HORTON J., COHEN J., GRUNDY S.M., HOBBS H.H. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology, 2004, 40: 1387-1395.
5. MARCHESINI G., BRIZI M., MORSELLI-LABATE A.M., BIANCHI G., BUGIANESI E., MCCULLOUGH A.J., FORLANI G., MELCHIONDA N. Association of nonalcoholic fatty liver disease to insulin resistance. Am. J. Med., 1999, 107: 450-455.
6. CANKURTARAN M., TAYFUR O., YAVUZ B.B., GEYIK S., AKHAN O., ARSLAN S. Insulin resistance and metabolic syndrome in patients with NAFLD but without diabetes: effect of a 6 month regime intervention. Acta Gastroenterol. Belg., 2007, 70: 253-259.
7. CHITTURI S., ABEYGUNASEKERA S., FARRELL G.C., HOLMES-WALKER J., HUI J.M., FUNG C., KARIM R., LIN R., SAMARASINGHE D., LIDDLE C., WELTMAN M., GEORGE J. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology, 2002, 35: 373-379.
8. PAGANO G., PACINI G., MUSSO G., GAMBINO R., MECCA F., DEPETRIS N., CASSADER M., DAVID E., CAVALLO-PERIN P., RIZZETTO M. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology, 2002, 35: 367-372.
9. HUI J.M., HODGE A., FARRELL G.C., KENCH J.G., KRIKETOS A., GEORGE J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology, 2004, 40: 46-54.
10. ARVANITI V.A., THOMOPOULOS K.C., TSAMANDASS A., MAKRI M., PSYROGIANNIS A., VAFIADIS G., ASSIMAKOPOULOS S.F., LABROPOUPOU-KARATZA C. Serum adiponectin levels in different types of non alcoholic liver disease. Correlation with steatosis, necroinflammation and fibrosis. Acta Gastroenterol. Belg., 2008, 71: 355-360.
11. VAN DER POORTEN D., MILNER K.L., HUI J., HODGE A., TRENELL M.I., KENCH J.G., LONDON R., PEDUTO T., CHISHOLM D.J., GEORGE J. Visceral fat: a key mediator of steato hepatitis in metabolic liver disease. Hepatology, 2008, 48: 449-57.
12. MARCHESINI G., BRIZI M., BIANCHI G., TOMASSETI S., BUGIANESI E., LENZI M., MCCULLOUGH A.J., NATALE S., FORLANI G., MELCHIONDA N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes, 2001, 50: 1844-1850.
13. CORTEZ-PINTO H., CAMILO M.E., BAPTISTA A., DE OLIVIERA A.G., DE MOURA M.C. Nonalcoholic fatty liver: another feature of the metabolic syndrome? Clin. Nutr., 1999, 18: 353-358.
14. MARCHESINI G., BUGIANESI E., FORLANI G., CERRELLI F., LENZI M., MANINI R., NATALE S., VANNI E., VILLANOVA N., MELCHIONDA N., RIZZETTO M. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology, 2003, 37: 917-923.
15. VERRIJKEN A., FRANCQUE S., van Gaal L. The metabolic syndrome and the liver. Acta Gastroenterol. Belg., 2008, 71: 48-59.
16. CANBAKAN B., SENTURK H., TAHAN V., HATEMI I., BALCI H., TOPTAS T., SONSUZ A., VELET M., AYDIN S., DIRICAN A., OZGULLE S., OZBAY G. Clinical, biochemical and histological correlations in a group of non-drinker subjects with non-alcoholic fatty liver disease. Acta Gastroenterol. Belg., 2007, 70: 277-284.
17. WANLESS I.R., LENTZ J.S. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology, 1990, 12: 1106-1110.
18. BACON B.R., FARAHVASH M.J., JANNEY C.G., NEUSCHWANDERTETRI B.A. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology, 1994, 107: 1103-1109.
19. GAO A.B., XIAO Q., LI L.Y., GAO Y., ZHANG H.N., MIAO J. Epidemiological survey of the association between non alcoholic fatty liver disease and metabolic syndrome in civil servants of Chongqing city. Zhonghua Yu Fang Yi Xue Za Zhi, 2008, 42: 107-110.
20. KIM H.J., KIM H.J., LEE K.E., KIM D.J., KIM S.K., AHN C.W., LIM S.K., KIM K.R., LEE H.C., HUH K.B., CHA B.S. Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. Arch. Intern. Med., 2004, 164: 2169-2175.
21. SAADEH S., YOUNOSSI Z.M., REMER E.M., GRAMLICH T., ONG J.P., HURLEY M., MULLEN K.D., COOPER J.N., SHERIDAN M.J. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology, 2002, 123: 745-750.
22. RAIMONDO G., ALLAIN J.P., BRUNETTO M.R., BUENDIA M.A., CHEN D.S., COLOMBO M., CRAXI A., DONATO F., FERRARI C., GAETA G.B., GERLICH W.H., LEVRERO M., LOCARNINI S., MICHALAK T., MONDELLI M.U., PAWLOTSKY J.M., POLLICINO T., PRATI D., PUOTI M., SAMUEL D., SHOUVAL D., SMEDILE A., SQUADRITO G., TREPO C., VILLA E., WILL H., ZANETTI A.R., ZOULIM F. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J. Hepatol., 2008, 49: 652-657.
23. LEVY J.C., MATTHEWS D.R., HERMANS M.P. Correct Homeostasis Model Assessment (HOMA): evaluation uses the computer program. Diabetes Care, 1998, 21: 2191-2192.
24. EXPERT PANEL ON DETECTION EVALUATION AND TREATMENT OF HIGH BLOOD CHOLESTEROL IN ADULTS. Executive summary of the third report of National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA, 2001, 285: 2486-2497.
25. GRUNDY S.M., CLEEMAN J.I., DANIELS S.R., DONATO S.R., ECKEL R.H., FRANKLIN B.A., GORDON DJ., KRAUSS R.M., SAVAGE P.J., SMITH S.C. JR., SPERTUS J.A., COSTA F. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation, 2005, 112: 2735-2752.
26. BRUNT E.M., JANNEY C.G., DI BISCEGLIE A.M., NEUSCHWANDERTETRI B.A., BACON B.R. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol., 1999, 94: 2467-2474.
27. USLAN I., ACARTURK G., KARACA E., ALBAYRAK R., YUKSEL S., COLBAY M., KARAMAN O., AKCAN Y. The effects of weight loss on normal transaminase levels in obese patients. Am. J. Med. Sci., 2007, 334: 327-330.
28. ADAMS L.A., SANDERSON S., LINDOR K.D., ANGULO P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J. Hepatol., 2005, 42: 132-138.
29. TORRES D.M., HARRISON S.A. Diagnosis and therapy of nonalcoholic steatohepatitis. Gastroenterology, 2008, 134: 1682-1698.
30. LEE J.H., RHEE P.L., LEE J.K., LEE K.T., KIM J.J., KOH K.C., PAIK S.W., RHEE J.C., CHOI K.W. Role of hyperinsulinemia and glucose intolerance in the pathogenesis of nonalcoholic fatty liver in patients with normal body weight. Korean J. Intern. Med., 1998, 13: 12-14.
31. PARK S.H., KIM B.I., YUN J.W., KIM J.W., PARK D.I., CHO Y.K., SUNG I.K., PARK C.Y., SOHN C.I., JEON W.K., KIM H., RHEE E.J., LEE W.Y., KIM S.W. Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese asian men. J. Gastroenterol. Hepatol., 2004, 19: 694-698.
32. CHO Y.K., LEE W.Y., OH S.Y., PARK J.H., KIM H.J., PARK D.I., SOHN C.I., JEON W.K., KIM B.I., KIM S.W., OH K.W., YUN E.J., OH E.S. Factors affecting the serum levels of adipokines in Korean male patients with nonalcoholic fatty liver disease. Hepatogastroenterology, 2007, 54: 1512-1516.
33. JUN D.W., HAN J.H., KIM S.H., JANG E.C., KIM N.I., LEE J.S., SONG M.H., KIM S.H., JO Y.J., PARK Y.S. Association between low thigh fat and non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol., 2008, 23: 888-893.
34. SAVERYMUTTU S.H., JOSEPH A.E., MAXWELL J.D. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br. Med. J., 1986, 292: 13-15.
35. TCHERNOF A., POEHLMAN E.T., DESPRES J.P. Body fat distribution, the menopause transition, and hormone remplacement therapy. Diabetes Metab., 2000, 26: 12-20.
36. CARR M.C. The emergence of the metabolic syndrome with menopause. J. Clin. Endocrinol. Metab., 2003, 88: 2404-2411.
37. HOTTA K., YONEDA M., HYOGO H., OCHI H., MIZUSAWA S., UENO T., CHAYAMA K., NAKAJIMA A., NAKAO K., SEKINE A. Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease. BMC Med. Genet., 2010, 11: 172-180.
38. CHITTURI S., WONG V.W., FARRELL G. Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground. J. Gastroenterol. Hepatol., 2011, 26: 163-172.