Increased expression of dysbindin-1A leads to a selective deficit in NMDA receptor signaling in the hippocampus

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1345-1353

  Jeans, Alexander ^a   Malins, Richard ^a   Padamsey, Zahid ^a   Reinhart, Marcia ^a   Emptage, Nigel ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Glutamate receptors; Hippocampus; NMDA receptor; Schizophrenia; Synaptic plasticity; Trafficking

Indexed keywords

CLATHRIN; DYSBINDIN; DYSBINDIN 1A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLASMID DNA; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; ENDOCYTOSIS; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; RAT; SIGNAL TRANSDUCTION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BACTERIAL PROTEINS; BIOPHYSICS; CARRIER PROTEINS; CELLS, CULTURED; CLATHRIN; ELECTRIC STIMULATION; EMBRYO, MAMMALIAN; ENDOCYTOSIS; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; LONG-TERM POTENTIATION; LUMINESCENT PROTEINS; MALE; MICE; N-METHYLASPARTATE; NEURONS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; PROTEIN TRANSPORT; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN; TRANSFECTION;

EID: 80053600833     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.08.007     Document Type: Article

References (35)

1. N.C. Allen, S. Bagade, M.B. McQueen, J.P. Ioannidis, F.K. Kavvoura, M.J. Khoury, R.E. Tanzi, and L. Bertram Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database Nat. Genet. 40 2008 827 834 (Pubitemid 351913655)
2. T.V. Bliss, and G.L. Collingridge A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 1993 31 39 (Pubitemid 23020772)
3. N.J. Bray, A. Preece, N.M. Williams, V. Moskvina, P.R. Buckland, M.J. Owen, and M.C. O'Donovan Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression Hum. Mol. Genet. 14 2005 1947 1954 (Pubitemid 41418031)
4. G.J. Brewer, J.R. Torricelli, E.K. Evege, and P.J. Price Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination J. Neurosci. Res. 35 1993 567 576 (Pubitemid 23215708)
5. G.L. Collingridge, J.T. Isaac, and Y.T. Wang Receptor trafficking and synaptic plasticity Nat. Rev. Neurosci. 5 2004 952 962 (Pubitemid 39593358)
6. A. De Simoni, and L.M. Yu Preparation of organotypic hippocampal slice cultures: interface method Nat. Protoc. 1 2006 1439 1445
7. V.A. Derkach, M.C. Oh, E.S. Guire, and T.R. Soderling Regulatory mechanisms of AMPA receptors in synaptic plasticity Nat. Rev. Neurosci. 8 2007 101 113 (Pubitemid 46151040)
8. S. Dwyer, L. Carroll, K.K. Mantripragada, M.J. Owen, M.C. O'Donovan, and N.M. Williams Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysis Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B 2010 766 774
9. N. Emptage, T.V. Bliss, and A. Fine Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines Neuron 22 1999 115 124 (Pubitemid 29070098)
10. M.V. Frantseva, P.B. Fitzgerald, R. Chen, B. Moller, M. Daigle, and Z.J. Daskalakis Evidence for impaired long-term potentiation in schizophrenia and its relationship to motor skill learning Cereb. Cortex 18 2008 990 996
11. P.A. Gaspar, M.L. Bustamante, H. Silva, and F. Aboitiz Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications J. Neurochem. 111 2009 891 900
12. Glen, W.B., Jentsch, D., Lavin, A, 2008. Genetic dysbindin deletion reduces synaptic plasticity in the CA1 region of the mouse hippocampus. In: Society for Neuroscience Annual Meeting, Washington, D.C.
13. J.T. Isaac, M. Ashby, and C.J. McBain The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity Neuron 54 2007 859 871 (Pubitemid 46907505)
14. Y. Ji, F. Yang, F. Papaleo, H.X. Wang, W.J. Gao, D.R. Weinberger, and B. Lu Role of dysbindin in dopamine receptor trafficking and cortical GABA function Proc. Natl. Acad. Sci. U S A 106 2009 19593 19598
15. J. Kantrowitz, and D.C. Javitt Glutamate and schizophrenia: phencyclidine, N-methyl-d-aspartate (NMDA) receptors: etiology and treatment D.C. Javitt, J.T. Kantrowitz, Handbook of Neurochemistry and Molecular Neurobiology 2009 Springer New York 39 92
16. K.H. Karlsgodt, K. Robleto, H. Trantham-Davidson, C. Jairl, T.D. Cannon, A. Lavin, and J.D. Jentsch Reduced dysbindin expression mediates N-methyl-d-aspartate receptor hypofunction and impaired working memory performance Biol. Psychiatry 2010
17. K.H. Karlsgodt, K. Robleto, H. Trantham-Davidson, C. Jairl, T.D. Cannon, A. Lavin, and J.D. Jentsch Reduced dysbindin expression mediates N-methyl-d-aspartate receptor hypofunction and impaired working memory performance Biol. Psychiatry 69 2011 28 34
18. C. Kehrer, N. Maziashvili, T. Dugladze, and T. Gloveli Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia Front. Mol. Neurosci. 1 2008 6
19. C.G. Lau, and R.S. Zukin NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders Nat. Rev. Neurosci. 8 2007 413 426 (Pubitemid 46789232)
20. W. Li, Q. Zhang, N. Oiso, E.K. Novak, R. Gautam, E.P. O'Brien, C.L. Tinsley, D.J. Blake, R.A. Spritz, and N.G. Copeland Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) Nat. Genet. 35 2003 84 89 (Pubitemid 37048600)
21. J. McGrath, S. Saha, D. Chant, and J. Welham Schizophrenia: a concise overview of incidence, prevalence, and mortality Epidemiol. Rev. 30 2008 67 76
22. D.W. Morris, K. Murphy, N. Kenny, S.M. Purcell, K.A. McGhee, S. Schwaiger, J.M. Nangle, G. Donohoe, S. Clarke, and P. Scully Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility Biol. Psychiatry 63 2008 24 31 (Pubitemid 350234879)
23. R. Nazarian, M. Starcevic, M.J. Spencer, and E.C. Dell'Angelica Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein Biochem. J. 395 2006 587 598
24. K. Prybylowski, and R.J. Wenthold N-Methyl-d-aspartate receptors: subunit assembly and trafficking to the synapse J. Biol. Chem. 279 2004 9673 9676 (Pubitemid 38372561)
25. A. Reichenberg, and P.D. Harvey Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings Psychol. Bull. 133 2007 833 858
26. J.C. Shieh, B.T. Schaar, K. Srinivasan, F.M. Brodsky, and S.K. McConnell Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons PLoS One 6 2011 e17802
27. L. Stoppini, P.A. Buchs, and D. Muller A simple method for organotypic cultures of nervous tissue J. Neurosci. Methods 37 1991 173 182
28. J. Sun, P.H. Kuo, B.P. Riley, K.S. Kendler, and Z. Zhao Candidate genes for schizophrenia: a survey of association studies and gene ranking Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B 2008 1173 1181
29. K. Talbot, W.L. Eidem, C.L. Tinsley, M.A. Benson, E.W. Thompson, R.J. Smith, C.G. Hahn, S.J. Siegel, J.Q. Trojanowski, and R.E. Gur Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia J. Clin. Invest. 113 2004 1353 1363 (Pubitemid 39069934)
30. K. Talbot, W.Y. Ong, D.J. Blake, J. Tang, N. Louneva, G.C. Carlson, and S.E. Arnold Dysbindin-1 and its protein family with special attention to the potential role of dysbindin-1 in neuronal functions and the pathophysiology of schizophrenia D.C. Javitt, J.T. Kantrowitz, Handbook of Neurochemistry and Molecular Neurobiology 2009 Springer New York 194 197
31. J. Tang, R.P. LeGros, N. Louneva, L. Yeh, J.W. Cohen, C.G. Hahn, D.J. Blake, S.E. Arnold, and K. Talbot Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression Hum. Mol. Genet. 18 2009 3851 3863
32. T.T. Tang, F. Yang, B.S. Chen, Y. Lu, Y. Ji, K.W. Roche, and B. Lu Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression Proc. Natl. Acad. Sci. U S A 106 2009 21395 21400
33. M. Tsuang Schizophrenia: genes and environment Biol. Psychiatry 47 2000 210 220 (Pubitemid 30077397)
34. C.S. Weickert, D.A. Rothmond, T.M. Hyde, J.E. Kleinman, and R.E. Straub Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients Schizophr. Res. 98 2008 105 110 (Pubitemid 350245587)
35. J.R. Whitlock, A.J. Heynen, M.G. Shuler, and M.F. Bear Learning induces long-term potentiation in the hippocampus Science 313 2006 1093 1097 (Pubitemid 44300229)