The role of nucleoside/nucleotide transport and metabolism in the uptake and retention of 3'-fluoro-3'-deoxythymidine in human B-lymphoblast cells

Nuclear Medicine and Biology

Volumn 38, Issue 7, 2011, Pages 979-986

  Plotnik, David A ^a   McLaughlin, Lena J ^a   Chan, Jenny ^a   Redmayne Titley, Joshua N ^a   Schwartz, Jeffrey L ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

FLT Metabolism; FLT Transport; Nucleoside transporters; Nucleotide transporters

Indexed keywords

3' FLUOROTHYMIDINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; THYMIDINE KINASE 1;

ARTICLE; B LYMPHOBLAST; CELL ACTIVITY; CELL CLONE; CELL DIVISION; CELL GROWTH; CELL ISOLATION; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG RETENTION; DRUG UPTAKE; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; NUCLEOSIDE TRANSPORT; NUCLEOTIDE METABOLISM; NUCLEOTIDE TRANSPORT; PROTEIN ANALYSIS; PROTEIN FUNCTION;

BIOLOGICAL TRANSPORT; CELL LINE; CELL PROLIFERATION; DIDEOXYNUCLEOSIDES; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; HUMANS; LYMPHOCYTES; NUCLEOTIDES; SODIUM; THYMIDINE KINASE;

EID: 80053587121     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.03.009     Document Type: Article

References (31)

1. Krohn K.A., Mankoff D.A., Eary J.F. Imaging cellular proliferation as a measure of response to therapy. J Clin Pharmacol 2001, (Suppl):96S-103S.
2. Bading J.R., Shahinian A.H., Bathija P., Conti P.S. Pharmacokinetics of the thymidine analog 2'-fluoro-5-[(14)C]-methyl-1-beta-d-arabinofuranosyluracil ([(14)C]FMAU) in rat prostate tumor cells. Nucl Med Biol 2000, 27:361-368.
3. 76Br-BFU as proliferation markers. J Nucl Med 2002, 43:1688-1698.
4. Shields A.F.P.E.T. Imaging with (18)F-FLT and thymidine analogs: promise and pitfalls. J Nucl Med 2003, 44:1432-1434.
5. Buck A.K., Halter G., Schirrmeister H., Kotzerke J., Wurziger I., Glatting G., et al. Imaging proliferation in lung tumors with PET: (18)F-FLT versus (18)F-FDG. J Nucl Med 2003, 44:1426-1431.
6. Rasey J.S., Grierson J.R., Wiens L.W., Kolb P.D., Schwartz J.L. Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells. J Nucl Med 2002, 43:1210-1217.
7. Paproski R.J., Ng A.M., Yao S.Y., Graham K., Young J.D., Cass C.E. The role of human nucleoside transporters in uptake of 3'-deoxy-3'-fluorothymidine. Mol Pharmacol 2008, 74:1372-1380.
8. Paproski R.J., Wuest M., Jans H.S., Graham K., Gati W.P., McQuarrie S., et al. Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model. J Nucl Med 2010, 51:1447-1455.
9. Paproski R.J., Young J.D., Cass C.E. Predicting gemcitabine transport and toxicity in human pancreatic cancer cell lines with the positron emission tomography tracer 3'-deoxy-3'-fluorothymidine. Biochem Pharmacol 2010, 79:587-595.
10. Plotnik D.A., Emerick L.E., Krohn K.A., Unadkat J.D., Schwartz J.L. Different modes of transport for 3H-thymidine, 3H-FLT, and 3H-FMAU in proliferating and nonproliferating human tumor cells. J Nucl Med 2010, 51:1464-1471.
11. Levy J.A., Virolainen M., Defendi V. Human lymphoblastoid lines from lymph node and spleen. Cancer 1968, 22:517-524.
12. Liber H.L., Thilly W.G. Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutat Res 1982, 94:467-485.
13. Sherley J.L., Kelly T.J. Regulation of human thymidine kinase during the cell cycle. J Biol Chem 1988, 263:8350-8358.
14. Hruby D.E., Ball L.A. Cell-free synthesis of enzymatically active vaccinia virus thymidine kinase. Virology 1981, 113:594-601.
15. van der Wilt C.L., Backus H.H., Smid K., Comijn L., Veerman G., Wouters D., et al. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. Cancer Res 2001, 61:3675-3681.
16. Huang D., Zhang Y., Chen X. Analysis of intracellular nucleoside triphosphate levels in normal and tumor cell lines by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2003, 784:101-109.
17. Watanabe T., Kokubu N., Charnick S.B., Naito M., Tsuruo T., Cohen D. Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein. Br J Pharmacol 1997, 122:241-248.
18. Perumal M., Pillai R.G., Barthel H., Leyton J., Latigo J.R., Forster M., et al. Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography. Cancer Res 2006, 66:8558-8564.
19. Belt J.A., Marina N.M., Phelps D.A., Crawford C.R. Nucleoside transport in normal and neoplastic cells. Adv Enzyme Regul 1993, 33:235-252.
20. Cass C.E., Young J.D., Baldwin S.A., Cabrita M.A., Graham K.A., Griffiths M., et al. Nucleoside transporters of mammalian cells. Pharm Biotechnol 1999, 12:313-352.
21. Hyde R.J., Cass C.E., Young J.D., Baldwin S.A. The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol Membr Biol 2001, 18:53-63.
22. Kong W., Engel K., Wang J. Mammalian nucleoside transporters. Curr Drug Metab 2004, 5:63-84.
23. del Santo B., Valdes R., Mata J., Felipe A., Casado F.J., Pastor-Anglada M. Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells. Hepatology 1998, 28:1504-1511.
24. Soler C., Garcia-Manteiga J., Valdes R., Xaus J., Comalada M., Casado F.J., et al. Macrophages require different nucleoside transport systems for proliferation and activation. Faseb J 2001, 15:1979-1988.
25. Grierson J.R., Schwartz J.L., Muzi M., Jordan R., Krohn K.A. Metabolism of 3'-deoxy-3'-[F-18]fluorothymidine in proliferating A549 cells: validations for positron emission tomography. Nucl Med Biol 2004, 31:829-837.
26. Guo Y., Kotova E., Chen Z.S., Lee K., Hopper-Borge E., Belinsky M.G., et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem 2003, 278:29509-29514.
27. Rampazzo C., Gallinaro L., Milanesi E., Frigimelica E., Reichard P., Bianchi V. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease. Proc Natl Acad Sci U S A 2000, 97:8239-8244.
28. Williams M.V., Holliday J., Glaser R. Induction of a deoxyuridine triphosphate nucleotidohydrolase activity in Epstein-Barr virus-infected cells. Virology 1985, 142:326-333.
29. Schultes B.C., Fischbach E., Dahlmann N. Purification and characterization of two different thymidine-5'-triphosphosphate-hydrolysing enzymes in human serum. Biol Chem Hoppe Seyler 1992, 373:237-247.
30. 3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines. Nucl Med Biol 2002, 29:281-287.
31. Schwartz J.L., Tamura Y., Jordan R., Grierson J.R., Krohn K.A. Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs. J Nucl Med 2003, 44:2027-2032.