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Volumn 172, Issue 1-3, 2011, Pages 69-76

Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a

Author keywords

Biomarker; Cardiovascular; Ghrelin; GHS R1a; Heart; Imaging

Indexed keywords

CELL SURFACE RECEPTOR; FLUORESCEIN GHRELIN[1-18]; FLUORESCEIN ISOTHIOCYANATE; GHRELIN; HEXARELIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REAGENT; UNCLASSIFIED DRUG;

EID: 80053576987     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2011.08.011     Document Type: Article
Times cited : (43)

References (36)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 43049127435 scopus 로고    scopus 로고
    • Ghrelin: a new peptide regulating growth hormone release and food intake
    • De Vriese C., Delporte C. Ghrelin: a new peptide regulating growth hormone release and food intake. Int J Biochem Cell Biol 2008, 40:1420-1424.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1420-1424
    • De Vriese, C.1    Delporte, C.2
  • 3
    • 0346949031 scopus 로고    scopus 로고
    • Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing
    • Hosoda H., Kojima M., Mizushima T., Shimizu S., Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem 2003, 278:64-70.
    • (2003) J Biol Chem , vol.278 , pp. 64-70
    • Hosoda, H.1    Kojima, M.2    Mizushima, T.3    Shimizu, S.4    Kangawa, K.5
  • 4
    • 77955417391 scopus 로고    scopus 로고
    • The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine
    • Grossauer J., Kosol S., Schrank E., Zangger K. The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine. Bioorg Med Chem 2010, 18:5483-5488.
    • (2010) Bioorg Med Chem , vol.18 , pp. 5483-5488
    • Grossauer, J.1    Kosol, S.2    Schrank, E.3    Zangger, K.4
  • 5
    • 49449085708 scopus 로고    scopus 로고
    • Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides
    • Yang J., Zhao T.J., Goldstein J.L., Brown M.S. Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci USA 2008, 105:10750-10755.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10750-10755
    • Yang, J.1    Zhao, T.J.2    Goldstein, J.L.3    Brown, M.S.4
  • 6
    • 70449633250 scopus 로고    scopus 로고
    • Ghrelin-a novel generation of anti-obesity drug: design, pharmacomodulation and biological activity of ghrelin analogues
    • Chollet C., Meyer K., Beck-Sickinger A.G. Ghrelin-a novel generation of anti-obesity drug: design, pharmacomodulation and biological activity of ghrelin analogues. J Pept Sci 2009, 15:711-730.
    • (2009) J Pept Sci , vol.15 , pp. 711-730
    • Chollet, C.1    Meyer, K.2    Beck-Sickinger, A.G.3
  • 9
    • 33947301456 scopus 로고    scopus 로고
    • The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor
    • Leung P.K., Chow K.B., Lau P.N., Chu K.M., Chan C.B., Cheng C.H., Wise H. The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell Signal 2007, 19:1011-1022.
    • (2007) Cell Signal , vol.19 , pp. 1011-1022
    • Leung, P.K.1    Chow, K.B.2    Lau, P.N.3    Chu, K.M.4    Chan, C.B.5    Cheng, C.H.6    Wise, H.7
  • 10
    • 11144225093 scopus 로고    scopus 로고
    • Common structural basis for constitutive activity of the ghrelin receptor family
    • Holst B., Holliday N.D., Bach A., Elling C.E., Cox H.M., Schwartz T.W. Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem 2004, 279:53806-53817.
    • (2004) J Biol Chem , vol.279 , pp. 53806-53817
    • Holst, B.1    Holliday, N.D.2    Bach, A.3    Elling, C.E.4    Cox, H.M.5    Schwartz, T.W.6
  • 11
    • 73649109875 scopus 로고    scopus 로고
    • Activation of the ghrelin receptor is described by a privileged collective motion: a model for constitutive and agonist-induced activation of a sub-class A G-protein coupled receptor (GPCR)
    • Floquet N., M'Kadmi C., Perahia D., Gagne D., Berge G., Marie J., Baneres J.L., Galleyrand J.C., Fehrentz J.A., Martinez J. Activation of the ghrelin receptor is described by a privileged collective motion: a model for constitutive and agonist-induced activation of a sub-class A G-protein coupled receptor (GPCR). J Mol Biol 2010, 395:769-784.
    • (2010) J Mol Biol , vol.395 , pp. 769-784
    • Floquet, N.1    M'Kadmi, C.2    Perahia, D.3    Gagne, D.4    Berge, G.5    Marie, J.6    Baneres, J.L.7    Galleyrand, J.C.8    Fehrentz, J.A.9    Martinez, J.10
  • 14
    • 0034741715 scopus 로고    scopus 로고
    • 9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis
    • 9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis. Br J Pharmacol 2001, 134:143-149.
    • (2001) Br J Pharmacol , vol.134 , pp. 143-149
    • Katugampola, S.D.1    Pallikaros, Z.2    Davenport, A.P.3
  • 15
    • 65249163244 scopus 로고    scopus 로고
    • Fluorine and rhenium substituted ghrelin analogues as potential imaging probes for the growth hormone secretagogue receptor
    • Rosita D., Dewit M.A., Luyt L.G. Fluorine and rhenium substituted ghrelin analogues as potential imaging probes for the growth hormone secretagogue receptor. J Med Chem 2009, 52:2196-2203.
    • (2009) J Med Chem , vol.52 , pp. 2196-2203
    • Rosita, D.1    Dewit, M.A.2    Luyt, L.G.3
  • 16
    • 75449096219 scopus 로고    scopus 로고
    • Design, synthesis and in vitro characterization of glucagon-like peptide-1 derivatives for pancreatic beta cell imaging by SPECT
    • Behnam Azad B., Rota V.A., Breadner D., Dhanvantari S., Luyt L.G. Design, synthesis and in vitro characterization of glucagon-like peptide-1 derivatives for pancreatic beta cell imaging by SPECT. Bioorg Med Chem 2010, 18:1265-1272.
    • (2010) Bioorg Med Chem , vol.18 , pp. 1265-1272
    • Behnam Azad, B.1    Rota, V.A.2    Breadner, D.3    Dhanvantari, S.4    Luyt, L.G.5
  • 17
    • 34548487757 scopus 로고    scopus 로고
    • Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and beta-arrestins
    • Camina J.P., Lodeiro M., Ischenko O., Martini A.C., Casanueva F.F. Stimulation by ghrelin of p42/p44 mitogen-activated protein kinase through the GHS-R1a receptor: role of G-proteins and beta-arrestins. J Cell Physiol 2007, 213:187-200.
    • (2007) J Cell Physiol , vol.213 , pp. 187-200
    • Camina, J.P.1    Lodeiro, M.2    Ischenko, O.3    Martini, A.C.4    Casanueva, F.F.5
  • 19
    • 84855642990 scopus 로고    scopus 로고
    • Towards PET imaging of intact pancreatic beta cell mass: a transgenic strategy
    • EPub ahead of print
    • McGirr R., Hu S., Yee S.P., Kovacs M.S., Lee T.Y., Dhanvantari S. Towards PET imaging of intact pancreatic beta cell mass: a transgenic strategy. Mol Imaging Biol 2010, EPub ahead of print.
    • (2010) Mol Imaging Biol
    • McGirr, R.1    Hu, S.2    Yee, S.P.3    Kovacs, M.S.4    Lee, T.Y.5    Dhanvantari, S.6
  • 20
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • Bednarek M.A., Feighner S.D., Pong S.S., McKee K.K., Hreniuk D.L., Silva M.V., Warren V.A., Howard A.D., Van Der Ploeg L.H., Heck J.V. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 2000, 43:4370-4376.
    • (2000) J Med Chem , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3    McKee, K.K.4    Hreniuk, D.L.5    Silva, M.V.6    Warren, V.A.7    Howard, A.D.8    Van Der Ploeg, L.H.9    Heck, J.V.10
  • 22
    • 2942525145 scopus 로고    scopus 로고
    • Ala-scan of ghrelin (1-14): interaction with the recombinant human ghrelin receptor
    • Van Craenenbroeck M., Gregoire F., De Neef P., Robberecht P., Perret J. Ala-scan of ghrelin (1-14): interaction with the recombinant human ghrelin receptor. Peptides 2004, 25:959-965.
    • (2004) Peptides , vol.25 , pp. 959-965
    • Van Craenenbroeck, M.1    Gregoire, F.2    De Neef, P.3    Robberecht, P.4    Perret, J.5
  • 25
    • 78149363277 scopus 로고    scopus 로고
    • Selective labelling of stromal cell-derived factor 1alpha with carboxyfluorescein to study receptor internalisation
    • Bellmann-Sickert K., Baumann L., Beck-Sickinger A.G. Selective labelling of stromal cell-derived factor 1alpha with carboxyfluorescein to study receptor internalisation. J Pept Sci 2010, 16:568-574.
    • (2010) J Pept Sci , vol.16 , pp. 568-574
    • Bellmann-Sickert, K.1    Baumann, L.2    Beck-Sickinger, A.G.3
  • 26
    • 79953003027 scopus 로고    scopus 로고
    • Design of fluorescent bradykinin analogs: application to imaging of B2 receptor-mediated agonist endocytosis and trafficking and angiotensin-converting enzyme
    • Gera L., Bawolak M.T., Roy C., Lodge R., Marceau F. Design of fluorescent bradykinin analogs: application to imaging of B2 receptor-mediated agonist endocytosis and trafficking and angiotensin-converting enzyme. J Pharmacol Exp Ther 2011, 337:33-41.
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 33-41
    • Gera, L.1    Bawolak, M.T.2    Roy, C.3    Lodge, R.4    Marceau, F.5
  • 29
    • 4143111272 scopus 로고    scopus 로고
    • Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
    • Wu R., Zhou M., Cui X., Simms H.H., Wang P. Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. Am J Physiol Heart Circ Physiol 2004, 287:H1296-H1302.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Wu, R.1    Zhou, M.2    Cui, X.3    Simms, H.H.4    Wang, P.5
  • 30
    • 34748827410 scopus 로고    scopus 로고
    • The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas
    • Lai K.C., Cheng C.H., Leung P.S. The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas. Pancreas 2007, 35:e1-e8.
    • (2007) Pancreas , vol.35
    • Lai, K.C.1    Cheng, C.H.2    Leung, P.S.3
  • 32
    • 34548436635 scopus 로고    scopus 로고
    • + signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin
    • + signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin. Diabetes 2007, 56:2319-2327.
    • (2007) Diabetes , vol.56 , pp. 2319-2327
    • Dezaki, K.1    Kakei, M.2    Yada, T.3
  • 33
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    • Dezaki K., Sone H., Koizumi M., Nakata M., Kakei M., Nagai H., Hosoda H., Kangawa K., Yada T. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 2006, 55:3486-3493.
    • (2006) Diabetes , vol.55 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6    Hosoda, H.7    Kangawa, K.8    Yada, T.9
  • 34
    • 35948975083 scopus 로고    scopus 로고
    • Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors
    • Muccioli G., Baragli A., Granata R., Papotti M., Ghigo E. Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors. Neuroendocrinology 2007, 86:147-164.
    • (2007) Neuroendocrinology , vol.86 , pp. 147-164
    • Muccioli, G.1    Baragli, A.2    Granata, R.3    Papotti, M.4    Ghigo, E.5
  • 35
    • 4544363024 scopus 로고    scopus 로고
    • Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study
    • Demers A., McNicoll N., Febbraio M., Servant M., Marleau S., Silverstein R., Ong H. Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study. Biochem J 2004, 382:417-424.
    • (2004) Biochem J , vol.382 , pp. 417-424
    • Demers, A.1    McNicoll, N.2    Febbraio, M.3    Servant, M.4    Marleau, S.5    Silverstein, R.6    Ong, H.7


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