A comparison of immune reconstitution and graft-versus-host disease following myeloablative conditioning versus reduced toxicity conditioning and umbilical cord blood transplantation in paediatric recipients

British Journal of Haematology

Volumn 155, Issue 2, 2011, Pages 218-234

  Geyer, Mark B ^a   Jacobson, Judith S ^a   Freedman, Jason ^a   George, Diane ^a   Moore, Virginia ^a   Van De Ven, Carmella ^a   Satwani, Prakash ^a   Bhatia, Monica ^a   Garvin, James H ^a   Bradley, Mary Brigid ^a   Harrison, Lauren ^a   Morris, Erin ^a   Della Latta, Phyllis ^b   Schwartz, Joseph ^b   Baxter Lowe, Lee A ^c   Cairo, Mitchell S ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cord blood transplantation; Graft versus host disease; Immune; Immunology; Paediatrics

Indexed keywords

ALEMTUZUMAB; BUSULFAN; CYCLOPHOSPHAMIDE; FLUDARABINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MELPHALAN; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ARTICLE; CANCER RELAPSE; CHILD; CHIMERA; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE SEVERITY; ENGRAFTMENT; FEMALE; FOLLOW UP; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; IMMUNE RECONSTITUTION; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYELOABLATIVE CONDITIONING; NATURAL KILLER CELL; OPPORTUNISTIC INFECTION; OVERALL SURVIVAL; PRIORITY JOURNAL; REDUCED TOXICITY CONDITIONING; RISK FACTOR; SCHOOL CHILD; T LYMPHOCYTE; WHOLE BODY RADIATION;

ANTIBIOTIC PROPHYLAXIS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODIES, NEOPLASM; ANTILYMPHOCYTE SERUM; BUSULFAN; CHILD; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; CYCLOPHOSPHAMIDE; FEMALE; GENETIC DISEASES, INBORN; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LEUKOCYTE COUNT; MALE; MELPHALAN; MYELOABLATIVE AGONISTS; NEOPLASMS; NEUTROPHILS; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; T-LYMPHOCYTES; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; VIDARABINE; WHOLE-BODY IRRADIATION;

EID: 80053560138     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08822.x     Document Type: Article

References (82)

1. Alatrash, G., de Lima, M., Hamerschlak, N., Pelosini, M., Wang, X., Xiao, L., Kerbauy, F., Chiattone, A., Rondon, G., Qazilbash, M.H., Giralt, S.A., de Padua Silva, L., Hosing, C., Kebriaei, P., Zhang, W., Nieto, Y., Saliba, R.M., Champlin, R.E. & Andersson, B.S. (2011) Myeloablative reduced-toxicity i.v. busulfan-fludarabine and allogeneic hematopoietic stem cell transplant for patients with acute myeloid leukemia or myelodysplastic syndrome in the sixth through eighth decades of life. Biology of Blood and Marrow Transplantation, doi: .
2. Anasetti, C. & Hansen, J.A. (1994) Effect of HLA incompatibility in marrow transplantation from unrelated and HLA-mismatched related donors. Transfusion Science, 15, 221-230.
3. Ayello, J., van de Ven, C., Fortino, W., Wade-Harris, C., Satwani, P., Baxi, L., Simpson, L.L., Sanger, W., Pickering, D., Kurtzberg, J. & Cairo, M.S. (2006) Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. Biology of Blood and Marrow Transplantation, 12, 608-622.
4. Ayello, J., van de Ven, C., Cairo, E., Hochberg, J., Baxi, L., Satwani, P. & Cairo, M.S. (2009) Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: implications for adoptive cellular immunotherapy. Experimental Hematology, 37, 1216-1229.
5. Ballen, K.K., Spitzer, T.R., Yeap, B.Y., McAfee, S., Dey, B.R., Attar, E., Haspel, R., Kao, G., Liney, D., Alyea, E., Lee, S., Cutler, C., Ho, V., Soiffer, R. & Antin, J.H. (2007) Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biology of Blood and Marrow Transplantation, 13, 82-89.
6. Barker, J.N., Hough, R.E., van Burik, J.A., DeFor, T.E., MacMillan, M.L., O'Brien, M.R. & Wagner, J.E. (2005) Serious infections after unrelated donor transplantation in 136 children: impact of stem cell source. Biology of Blood and Marrow Transplantation, 11, 362-370.
7. Barker, J.N., Scaradavou, A. & Stevens, C.E. (2010) Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood, 115, 1843-1849.
8. Bhatia, M., Militano, O., Jin, Z., Figurski, M., Shaw, L., Moore, V., Morris, E., Tallamy, B., van deVen, C., Ayello, J., Baxter-Lowe, L., Satwani, P., George, D., Bradley, M.B., Garvin, J. & Cairo, M.S. (2010) An age-dependent pharmacokinetic study of intravenous and oral mycophenolate mofetil in combination with tacrolimus for GVHD prophylaxis in pediatric allogeneic stem cell transplantation recipients. Biology of Blood and Marrow Transplantation, 16, 333-343.
9. Bradley, M.B., Satwani, P., Baldinger, L., Morris, E., van de Ven, C., Del Toro, G., Garvin, J., George, D., Bhatia, M., Roman, E., Baxter-Lowe, L.A., Schwartz, J., Qualter, E., Hawks, R., Wolownik, K., Foley, S., Militano, O., Leclere, J., Cheung, Y.K. & Cairo, M.S. (2007) Reduced intensity allogeneic umbilical cord blood transplantation in children and adolescent recipients with malignant and non-malignant diseases. Bone Marrow Transplantation, 40, 621-631.
10. Brunstein, C.G., Barker, J.N., Weisdorf, D.J., DeFor, T.E., Miller, J.S., Blazar, B.R., McGlave, P.B. & Wagner, J.E. (2007) Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood, 110, 3064-3070.
11. Brunstein, C., Hippen, K.L., McKenna, D.H., Cao, Q., Curtsinger, J., Sumstad, D., Levine, B.L., Riley, J.L., June, C.H., Miller, J.S., Blazar, B.R. & Wagner, J.E. (2009) Adoptive transfer of umbilical cord blood (UCB)-derived regulatory T cells (Tregs) to recipients of nonmyeloablative unrelated double UCB transplantation. ASH Annual Meeting Abstracts, 114, 513.
12. Cairo, M.S., Wagner, E.L., Fraser, J., Cohen, G., van de Ven, C., Carter, S.L., Kernan, N.A. & Kurtzberg, J. (2005) Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion, 45, 856-866.
13. Chakraverty, R., Orti, G., Roughton, M., Shen, J., Fielding, A., Kottaridis, P., Milligan, D., Collin, M., Crawley, C., Johnson, P., Clark, A., Parker, A., Bloor, A., Pettengell, R., Snowden, J., Pettitt, A., Clark, R., Hale, G., Peggs, K., Thomson, K., Morris, E. & Mackinnon, S. (2010) Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantation: pharmacokinetics, GVHD, and immune reconstitution. Blood, 116, 3080-3088.
14. Chao, N.J., Liu, C.X., Rooney, B., Chen, B.J., Long, G.D., Vredenburgh, J.J., Morris, A., Gasparetto, C. & Rizzieri, D.A. (2002) Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells. Biology of Blood and Marrow Transplantation, 8, 249-256.
15. Condiotti, R., Zakai, Y.B., Barak, V. & Nagler, A. (2001) Ex vivo expansion of CD56+ cytotoxic cells from human umbilical cord blood. Experimental Hematology, 29, 104-113.
16. Couriel, D., Caldera, H., Champlin, R. & Komanduri, K. (2004) Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management. Cancer, 101, 1936-1946.
17. Crooks, G.M., Weinberg, K. & Mackall, C. (2006) Immune reconstitution: from stem cells to lymphocytes. Biology of Blood and Marrow Transplantation, 12, 42-46.
18. Dunbar, E.M., Buzzeo, M.P., Levine, J.B., Schold, J.D., Meier-Kriesche, H.U. & Reddy, V. (2008) The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease. Haematologica, 93, 1852-1858.
19. Eapen, M., Rubinstein, P., Zhang, M.J., Camitta, B.M., Stevens, C., Cairo, M.S., Davies, S.M., Doyle, J.J., Kurtzberg, J., Pulsipher, M.A., Ortega, J.J., Scaradavou, A., Horowitz, M.M. & Wagner, J.E. (2006) Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18months. Journal of Clinical Oncology, 24, 145-151.
20. Eapen, M., Rubinstein, P., Zhang, M.J., Stevens, C., Kurtzberg, J., Scaradavou, A., Loberiza, F.R., Champlin, R.E., Klein, J.P., Horowitz, M.M. & Wagner, J.E. (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet, 369, 1947-1954.
21. Fraser, J.K., Cairo, M.S., Wagner, E.L., McCurdy, P.R., Baxter-Lowe, L.A., Carter, S.L., Kernan, N.A., Lill, M.C., Slone, V., Wagner, J.E., Wallas, C.H. & Kurtzberg, J. (1998) Cord Blood Transplantation Study (COBLT): cord blood bank standard operating procedures. Journal of Hematotherapy, 7, 521-561.
22. Frias, A.M., Porada, C.D., Crapnell, K.B., Cabral, J.M., Zanjani, E.D. & Almeida-Porada, G. (2008) Generation of functional natural killer and dendritic cells in a human stromal-based serum-free culture system designed for cord blood expansion. Experimental Hematology, 36, 61-68.
23. Fujita, Y., Rooney, C.M. & Heslop, H.E. (2008) Adoptive cellular immunotherapy for viral diseases. Bone Marrow Transplantation, 41, 193-198.
24. Glucksberg, H., Storb, R., Fefer, A., Buckner, C.D., Neiman, P.E., Clift, R.A., Lerner, K.G. & Thomas, E.D. (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation, 18, 295-304.
25. Godfrey, W.R., Spoden, D.J., Ge, Y.G., Baker, S.R., Liu, B., Levine, B.L., June, C.H., Blazar, B.R. & Porter, S.B. (2005) Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 105, 750-758.
26. Hamza, N.S., Lisgaris, M., Yadavalli, G., Nadeau, L., Fox, R., Fu, P., Lazarus, H.M., Koc, O.N., Salata, R.A. & Laughlin, M.J. (2004) Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. British Journal of Haematology, 124, 488-498.
27. Hanley, P.J., Cruz, C.R., Savoldo, B., Leen, A.M., Stanojevic, M., Khalil, M., Decker, W., Molldrem, J.J., Liu, H., Gee, A.P., Rooney, C.M., Heslop, H.E., Dotti, G., Brenner, M.K., Shpall, E.J. & Bollard, C.M. (2009) Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood, 114, 1958-1967.
28. Hippen, K.L., Harker-Murray, P., Porter, S.B., Merkel, S.C., Londer, A., Taylor, D.K., Bina, M., Panoskaltsis-Mortari, A., Rubinstein, P., Van Rooijen, N., Golovina, T.N., Suhoski, M.M., Miller, J.S., Wagner, J.E., June, C.H., Riley, J.L. & Blazar, B.R. (2008) Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. Blood, 112, 2847-2857.
29. Ho, V.T., Mirza, N.Q., Junco Dd, D., Okamura, T. & Przepiorka, D. (2003) The effect of hematopoietic growth factors on the risk of graft-vs-host disease after allogeneic hematopoietic stem cell transplantation: a meta-analysis. Bone Marrow Transplantation, 32, 771-775.
30. Jimenez, M., Martinez, C., Ercilla, G., Carreras, E., Urbano-Ispizua, A., Aymerich, M., Villamor, N., Amezaga, N., Rovira, M., Fernandez-Aviles, F., Gaya, A., Martino, R., Sierra, J. & Montserrat, E. (2005) Reduced-intensity conditioning regimen preserves thymic function in the early period after hematopoietic stem cell transplantation. Experimental Hematology, 33, 1240-1248.
31. Junghanss, C., Boeckh, M., Carter, R.A., Sandmaier, B.M., Maris, M.B., Maloney, D.G., Chauncey, T., McSweeney, P.A., Little, M.T., Corey, L. & Storb, R. (2002) Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study. Blood, 99, 1978-1985.
32. Kaplan, E.L. & Meier, P. (1958) Nonparametric-estimation from incomplete observations. Journal of the American Statistical Association, 53, 457-481.
33. Komanduri, K.V., St John, L.S., de Lima, M., McMannis, J., Rosinski, S., McNiece, I., Bryan, S.G., Kaur, I., Martin, S., Wieder, E.D., Worth, L., Cooper, L.J., Petropoulos, D., Molldrem, J.J., Champlin, R.E. & Shpall, E.J. (2007) Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood, 110, 4543-4551.
34. Kurtzberg, J., Laughlin, M., Graham, M.L., Smith, C., Olson, J.F., Halperin, E.C., Ciocci, G., Carrier, C., Stevens, C.E. & Rubinstein, P. (1996) Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. New England Journal of Medicine, 335, 157-166.
35. Kurtzberg, J., Cairo, M.S., Fraser, J.K., Baxter-Lowe, L., Cohen, G., Carter, S.L. & Kernan, N.A. (2005) Results of the cord blood transplantation (COBLT) study unrelated donor banking program. Transfusion, 45, 842-855.
36. Kurtzberg, J., Prasad, V.K., Carter, S.L., Wagner, J.E., Baxter-Lowe, L.A., Wall, D., Kapoor, N., Guinan, E.C., Feig, S.A., Wagner, E.L. & Kernan, N.A. (2008) Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood, 112, 4318-4327.
37. Laughlin, M.J., Eapen, M., Rubinstein, P., Wagner, J.E., Zhang, M.J., Champlin, R.E., Stevens, C., Barker, J.N., Gale, R.P., Lazarus, H.M., Marks, D.I., van Rood, J.J., Scaradavou, A. & Horowitz, M.M. (2004) Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. New England Journal of Medicine, 351, 2265-2275.
38. Leen, A.M., Christin, A., Myers, G.D., Liu, H., Cruz, C.R., Hanley, P.J., Kennedy-Nasser, A.A., Leung, K.S., Gee, A.P., Krance, R.A., Brenner, M.K., Heslop, H.E., Rooney, C.M. & Bollard, C.M. (2009) Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Blood, 114, 4283-4292.
39. Liao, Y., Geyer, M.B., Yang, A.J. & Cairo, M.S. (2011) Cord blood transplantation and stem cell regenerative potential. Experimental Hematology, 39, 393-412.
40. Ljungman, P., Ward, K.N., Crooks, B.N., Parker, A., Martino, R., Shaw, P.J., Brinch, L., Brune, M., De La Camara, R., Dekker, A., Pauksen, K., Russell, N., Schwarer, A.P. & Cordonnier, C. (2001) Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplantation, 28, 479-484.
41. Lockitch, G., Halstead, A., Quigley, G. & MacCallum, C. (1988) Age- and sex-specific pediatric reference intervals: study design and methods illustrated by measurement of serum proteins with the Behring LN Nephelometer. Clinical Chemistry, 34, 1618-1621.
42. MacMillan, M.L., Weisdorf, D.J., Brunstein, C.G., Cao, Q., DeFor, T.E., Verneris, M.R., Blazar, B.R. & Wagner, J.E. (2009) Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors. Blood, 113, 2410-2415.
43. Majhail, N.S., Weisdorf, D.J., Wagner, J.E., Defor, T.E., Brunstein, C.G. & Burns, L.J. (2006) Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma. Blood, 107, 3804-3807.
44. Maris, M., Boeckh, M., Storer, B., Dawson, M., White, K., Keng, M., Sandmaier, B., Maloney, D., Storb, R. & Storek, J. (2003) Immunologic recovery after hematopoietic cell transplantation with nonmyeloablative conditioning. Experimental Hematology, 31, 941-952.
45. Martin, P.L., Carter, S.L., Kernan, N.A., Sahdev, I., Wall, D., Pietryga, D., Wagner, J.E. & Kurtzberg, J. (2006) Results of the cord blood transplantation study (COBLT): outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with lysosomal and peroxisomal storage diseases. Biology of Blood and Marrow Transplantation, 12, 184-194.
46. Mazur, M.A., Davis, C.C. & Szabolcs, P. (2008) Ex vivo expansion and Th1/Tc1 maturation of umbilical cord blood T cells by CD3/CD28 costimulation. Biology of Blood and Marrow Transplantation, 14, 1190-1196.
47. McSweeney, P.A., Niederwieser, D., Shizuru, J.A., Sandmaier, B.M., Molina, A.J., Maloney, D.G., Chauncey, T.R., Gooley, T.A., Hegenbart, U., Nash, R.A., Radich, J., Wagner, J.L., Minor, S., Appelbaum, F.R., Bensinger, W.I., Bryant, E., Flowers, M.E., Georges, G.E., Grumet, F.C., Kiem, H.P., Torok-Storb, B., Yu, C., Blume, K.G. & Storb, R.F. (2001) Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood, 97, 3390-3400.
48. Michel, G., Rocha, V., Chevret, S., Arcese, W., Chan, K.W., Filipovich, A., Takahashi, T.A., Vowels, M., Ortega, J., Bordigoni, P., Shaw, P.J., Yaniv, I., Machado, A., Pimentel, P., Fagioli, F., Verdeguer, A., Jouet, J.P., Diez, B., Ferreira, E., Pasquini, R., Rosenthal, J., Sievers, E., Messina, C., Iori, A.P., Garnier, F., Ionescu, I., Locatelli, F. & Gluckman, E. (2003) Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord Group analysis. Blood, 102, 4290-4297.
49. Micklethwaite, K.P., Savoldo, B., Hanley, P.J., Leen, A.M., Demmler-Harrison, G.J., Cooper, L.J., Liu, H., Gee, A.P., Shpall, E.J., Rooney, C.M., Heslop, H.E., Brenner, M.K., Bollard, C.M. & Dotti, G. (2010) Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood, 115, 2695-2703.
50. Mielcarek, M., Martin, P.J., Leisenring, W., Flowers, M.E., Maloney, D.G., Sandmaier, B.M., Maris, M.B. & Storb, R. (2003) Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation. Blood, 102, 756-762.
51. Moretta, A., Maccario, R., Fagioli, F., Giraldi, E., Busca, A., Montagna, D., Miniero, R., Comoli, P., Giorgiani, G., Zecca, M., Pagani, S. & Locatelli, F. (2001) Analysis of immune reconstitution in children undergoing cord blood transplantation. Experimental Hematology, 29, 371-379.
52. Morris, E.C., Rebello, P., Thomson, K.J., Peggs, K.S., Kyriakou, C., Goldstone, A.H., Mackinnon, S. & Hale, G. (2003) Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications. Blood, 102, 404-406.
53. Nakamae, H., Kirby, K.A., Sandmaier, B.M., Norasetthada, L., Maloney, D.G., Maris, M.B., Davis, C., Corey, L., Storb, R. & Boeckh, M. (2009) Effect of conditioning regimen intensity on CMV infection in allogeneic hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation, 15, 694-703.
54. Niehues, T., Rocha, V., Filipovich, A.H., Chan, K.W., Porcher, R., Michel, G., Ortega, J.J., Wernet, P., Gobel, U., Gluckman, E. & Locatelli, F. (2001) Factors affecting lymphocyte subset reconstitution after either related or unrelated cord blood transplantation in children - a Eurocord analysis. British Journal Haematology, 114, 42-48.
55. Oran, B., Wagner, J.E., DeFor, T.E., Weisdorf, D.J. & Brunstein, C.G. (2011) Effect of conditioning regimen intensity on acute myeloid leukemia outcomes after umbilical cord blood transplantation. Biology of Blood and Marrow Transplantation, doi: .
56. Osunkwo, I., Bessmertny, O., Harrison, L., Cheung, Y.K., Van de Ven, C., del Toro, G., Garvin, J., George, D., Bradley, M.B., Wolownik, K., Wischhover, C., Levy, J., Skerrett, D. & Cairo, M.S. (2004) A pilot study of tacrolimus and mycophenolate mofetil graft-versus-host disease prophylaxis in childhood and adolescent allogeneic stem cell transplant recipients. Biology of Blood and Marrow Transplantation, 10, 246-258.
57. Parkman, R., Cohen, G., Carter, S.L., Weinberg, K.I., Masinsin, B., Guinan, E., Kurtzberg, J., Wagner, J.E. & Kernan, N.A. (2006) Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation. Biology of Blood and Marrow Transplantation, 12, 919-927.
58. Parmar, S., Robinson, S.N., Komanduri, K., St John, L., Decker, W., Xing, D., Yang, H., McMannis, J., Champlin, R., de Lima, M., Molldrem, J., Rieber, A., Bonyhadi, M., Berenson, R. & Shpall, E.J. (2006) Ex vivo expanded umbilical cord blood T cells maintain naive phenotype and TCR diversity. Cytotherapy, 8, 149-157.
59. Pasquini, M.C. & Wang, Z. (2009) Current use and outcome of hematopoietic stem cell transplantation. Part I: CIBMTR summary slides. CIBMTR Newsletter, 1, 7-11.
60. Petersdorf, E.W., Smith, A.G., Haase, A.M., Martin, P.J. & Hansen, J.A. (1991) Polymorphism of HLA-DRw52-associated DRB1 genes as defined by sequence-specific oligonucleotide probe hybridization and sequencing. Tissue Antigens, 38, 169-177.
61. Porter, S.B., Liu, B., Rogosheske, J., Levine, B.L., June, C.H., Kohl, V.K., Wagner, J.E., Miller, J.S. & Blazar, B.R. (2006) Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugs. Transplantation, 82, 23-29.
62. Prasad, V.K., Mendizabal, A., Parikh, S.H., Szabolcs, P., Driscoll, T.A., Page, K., Lakshminarayanan, S., Allison, J., Wood, S., Semmel, D., Escolar, M.L., Martin, P.L., Carter, S. & Kurtzberg, J. (2008) Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood, 112, 2979-2989.
63. Pulsipher, M.A., Boucher, K.M., Wall, D., Frangoul, H., Duval, M., Goyal, R.K., Shaw, P.J., Haight, A.E., Grimley, M., Grupp, S.A., Kletzel, M. & Kadota, R. (2009) Reduced-intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313. Blood, 114, 1429-1436.
64. Rocha, V., Cornish, J., Sievers, E.L., Filipovich, A., Locatelli, F., Peters, C., Remberger, M., Michel, G., Arcese, W., Dallorso, S., Tiedemann, K., Busca, A., Chan, K.W., Kato, S., Ortega, J., Vowels, M., Zander, A., Souillet, G., Oakill, A., Woolfrey, A., Pay, A.L., Green, A., Garnier, F., Ionescu, I., Wernet, P., Sirchia, G., Rubinstein, P., Chevret, S. & Gluckman, E. (2001) Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood, 97, 2962-2971.
65. Rocha, V., Labopin, M., Sanz, G., Arcese, W., Schwerdtfeger, R., Bosi, A., Jacobsen, N., Ruutu, T., de Lima, M., Finke, J., Frassoni, F. & Gluckman, E. (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New England Journal of Medicine, 351, 2276-2285.
66. Rodriguez, R., Nademanee, A., Ruel, N., Smith, E., Krishnan, A., Popplewell, L., Zain, J., Patane, K., Kogut, N., Nakamura, R., Sarkodee-Adoo, C. & Forman, S.J. (2006) Comparison of reduced-intensity and conventional myeloablative regimens for allogeneic transplantation in non-Hodgkin's lymphoma. Biology of Blood and Marrow Transplantation, 12, 1326-1334.
67. Roman, E., Osunkwo, I., Militano, O., Cooney, E., van de Ven, C. & Cairo, M.S. (2008) Liposomal amphotericin B prophylaxis of invasive mold infections in children post allogeneic stem cell transplantation. Pediatric Blood & Cancer, 50, 325-330.
68. Rubinstein, P., Dobrila, L., Rosenfield, R.E., Adamson, J.W., Migliaccio, G., Migliaccio, A.R., Taylor, P.E. & Stevens, C.E. (1995) Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proceedings of the National Academy of Sciences of the United States of America, 92, 10119-10122.
69. Rubinstein, P., Carrier, C., Scaradavou, A., Kurtzberg, J., Adamson, J., Migliaccio, A.R., Berkowitz, R.L., Cabbad, M., Dobrila, N.L., Taylor, P.E., Rosenfield, R.E. & Stevens, C.E. (1998) Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New England Journal of Medicine, 339, 1565-1577.
70. Satwani, P., Baldinger, L., Freedman, J., Jacobson, J.S., Guerra, J., van de Ven, C., Morris, E., Garvin, J., George, D., Bradley, M.B., Bhatia, M., Tallamy, B., Schwartz, J., Jin, Z. & Cairo, M.S. (2009) Incidence of viral and fungal infections following busulfan-based reduced-intensity versus myeloablative conditioning in pediatric allogeneic stem cell transplantation recipients. Biology of Blood and Marrow Transplantation, 15, 1587-1595.
71. Schulenburg, A., Fischer, M., Kalhs, P., Mitterbauer, M., Rabitsch, W., Greinix, H.T. & Leitner, G. (2005) Immune recovery after conventional and non-myeloablative allogeneic stem cell transplantation. Leukaemia & Lymphoma, 46, 1755-1760.
72. Shereck, E.B., Cooney, E., van de Ven, C., Della-Lotta, P. & Cairo, M.S. (2007) A pilot phase II study of alternate day ganciclovir and foscarnet in preventing cytomegalovirus (CMV) infections in at-risk pediatric and adolescent allogeneic stem cell transplant recipients. Pediatric Blood & Cancer, 49, 306-312.
73. Styczynski, J., Cheung, Y.K., Garvin, J., Savage, D.G., Billote, G.B., Harrison, L., Skerrett, D., Wolownik, K., Wischhover, C., Hawks, R., Bradley, M.B., Del Toro, G., George, D., Yamashiro, D., van de Ven, C. & Cairo, M.S. (2004) Outcomes of unrelated cord blood transplantation in pediatric recipients. Bone Marrow Transplantation, 34, 129-136.
74. Styczynski, J., Tallamy, B., Waxman, I., van de Ven, C., Milone, M.C., Shaw, L.M., Harrison, L., Morris, E., Satwani, P., Bhatia, M., George, D., Bradley, M.B., Garvin, J.H., Schwartz, J., Baxter-Lowe, L.A. & Cairo, M.S. (2011) A pilot study of reduced toxicity conditioning with BU, fludarabine and alemtuzumab before the allogeneic hematopoietic SCT in children and adolescents. Bone Marrow Transplantation, 46, 790-799.
75. Szabolcs, P. & Cairo, M.S. (2010) Unrelated umbilical cord blood transplantation and immune reconstitution. Seminars in Hematology, 47, 22-36.
76. Szabolcs, P. & Niedzwiecki, D. (2007) Immune reconstitution after unrelated cord blood transplantation. Cytotherapy, 9, 111-122.
77. Talvensaari, K., Clave, E., Douay, C., Rabian, C., Garderet, L., Busson, M., Garnier, F., Douek, D., Gluckman, E., Charron, D. & Toubert, A. (2002) A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood, 99, 1458-1464.
78. Thomson, B.G., Robertson, K.A., Gowan, D., Heilman, D., Broxmeyer, H.E., Emanuel, D., Kotylo, P., Brahmi, Z. & Smith, F.O. (2000) Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation. Blood, 96, 2703-2711.
79. Wagner, J.E., Rosenthal, J., Sweetman, R., Shu, X.O., Davies, S.M., Ramsay, N.K., McGlave, P.B., Sender, L. & Cairo, M.S. (1996) Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood, 88, 795-802.
80. Wagner, J.E., Barker, J.N., DeFor, T.E., Baker, K.S., Blazar, B.R., Eide, C., Goldman, A., Kersey, J., Krivit, W., MacMillan, M.L., Orchard, P.J., Peters, C., Weisdorf, D.J., Ramsay, N.K. & Davies, S.M. (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood, 100, 1611-1618.
81. Waxman, I.M., Militano, O., Baldinger, L., Roman, E., Qualter, E., Morris, E., Garvin, J., Bradley, M.B., Bhatia, M., Satwani, P., George, D., Del Toro, G., Hawks, R., Wolownik, K., Foley, S., Cheung, Y.K., Schwartz, J., van de Ven, C., Baxter-Lowe, L.A. & Cairo, M.S. (2009) Sequential administration of sargramostim and filgrastim in pediatric allogeneic stem cell transplantation recipients undergoing myeloablative conditioning. Pediatric Transplantation, 13, 464-474.
82. Yuji, K., Miyakoshi, S., Kato, D., Miura, Y., Myojo, T., Murashige, N., Kishi, Y., Kobayashi, K., Kusumi, E., Narimatsu, H., Hamaki, T., Matsumura, T., Kami, M., Fukuda, T., Masuo, S., Masuoka, K., Wake, A., Ueyama, J., Yoneyama, A., Miyamoto, K., Nagoshi, H., Matsuzaki, M., Morinaga, S., Muto, Y., Takeue, Y. & Taniguchi, S. (2005) Reduced-intensity unrelated cord blood transplantation for patients with advanced malignant lymphoma. Biology of Blood and Marrow Transplantation, 11, 314-318.