Ex Vivo Expansion and Th1/Tc1 Maturation of Umbilical Cord Blood T Cells by CD3/CD28 Costimulation

Biology of Blood and Marrow Transplantation

Volumn 14, Issue 10, 2008, Pages 1190-1196

  Mazur, Melissa A ^a   Davis, Craig C ^a   Szabolcs, Paul ^a,b  

^a Department of Pediatrics Pediatric Blood and Marrow Transplantation ^*  (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD3 ANTIBODY; CD3 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR ALPHA; INTERLEUKIN 2; L SELECTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOWN REGULATION; EX VIVO STUDY; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LEUKOCYTE TRANSFUSION; LYMPHOCYTE PROLIFERATION; T LYMPHOCYTE; TH1 CELL; THAWING; UMBILICAL CORD BLOOD;

ANTIGENS, CD28; ANTIGENS, CD3; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; FEASIBILITY STUDIES; FETAL BLOOD; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TH1 CELLS;

EID: 51649085790     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2008.07.016     Document Type: Article

References (29)

1. Szabolcs P., and Niedzwiecki D. Immune reconstitution after unrelated cord blood transplantation. Cytotherapy 9 (2007) 111-122
2. Goodwin V.J., Sato T.A., Mitchell M.D., et al. Anti-inflammatory effects of interleukin-4, interleukin-10, and transforming growth factor-beta on human placental cells in vitro. Am J Reprod Immunol 40 (1998) 319-325
3. Marchant A., and Goldman M. T cell-mediated immune responses in human newborns: ready to learn?. Clin Exp Immunol 141 (2005) 10-18
4. Chalmers I.M., Janossy G., Contreras M., et al. Intracellular cytokine profile of cord and adult blood lymphocytes. Blood 92 (1998) 11-18
5. Risdon G., Gaddy J., Stehman F.B., et al. Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation. Cell Immunol 154 (1994) 14-24
6. Broxmeyer H.E. American Association of Blood Banks. Cord Blood: Biology, Immunology, and Clinical Transplantation (2004), AABB Press, Bethesda, MD
7. Berthou C., Legros-Maida S., Soulie A., et al. Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes. Blood 85 (1995) 1540-1546
8. Ribeiro-do-Couto L.M., Boeije L.C., Kroon J.S., et al. High IL-13 production by human neonatal T cells: neonate immune system regulator?. Eur J Immunol 31 (2001) 3394-3402
9. - T cells. J Immunol 168 (2002) 2820-2827
10. Papadopoulos E.B., Ladanyi M., Emanuel D., et al. Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N Engl J Med 330 (1994) 1185-1191
11. Hromas R., Cornetta K., Srour E., et al. Donor leukocyte infusion as therapy of life-threatening adenoviral infections after T-cell-depleted bone marrow transplantation. Blood 84 (1994) 1689-1690
12. + T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat Med 8 (2002) 47-53
13. +-selected hematopoietic cell transplantation. Blood 102 (2003) 2004-2013
14. Bonyhadi M., Frohlich M., Rasmussen A., et al. In vitro engagement of CD3 and CD28 corrects T cell defects in chronic lymphocytic leukemia. J Immunol 174 (2005) 2366-2375
15. Porter D.L., Levine B.L., Bunin N., et al. A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood 107 (2006) 1325-1331
16. June C.H., Ledbetter J.A., Linsley P.S., et al. Role of the CD28 receptor in T-cell activation. Immunol Today 11 (1990) 211-216
17. Parmar S., Robinson S.N., Komanduri K., et al. Ex vivo expanded umbilical cord blood T cells maintain naive phenotype and TCR diversity. Cytotherapy 8 (2006) 149-157
18. Szabolcs P., Park K.D., Reese M., et al. Coexistent naive phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. Exp Hematol 31 (2003) 708-714
19. Szabolcs P., Park K.D., Marti L., et al. Superior depletion of alloreactive T cells from peripheral blood stem cell and umbilical cord blood grafts by the combined use of trimetrexate and interleukin-2 immunotoxin. Biol Blood Marrow Transplant 10 (2004) 772-783
20. LaSalle J.M., and Hafler D.A. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cell Immunol 138 (1991) 197-206
21. Maccario R., Chirico G., Mingrat G., et al. Expression of CD45R0 antigen on the surface of resting and activated neonatal T lymphocyte subsets. Biol Neonate 64 (1993) 346-353
22. Picker L.J., Treer J.R., Ferguson-Darnell B., et al. Control of lymphocyte recirculation in man, I: Differential regulation of the peripheral lymph node homing receptor L-selection on T cells during the virgin to memory cell transition. J Immunol 150 (1993) 1105-1121
23. + T cells differently expressing three cytolytic effector molecules. J Immunol 177 (2006) 4330-4340
24. +)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 105 (2005) 750-758
25. + regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106 (2005) 3068-3073
26. Williams M.A., and Bevan M.J. Effector and memory CTL differentiation. Annu Rev Immunol 25 (2007) 171-192
27. Walker R.E., Bechtel C.M., Natarajan V., et al. Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96 (2000) 467-474
28. Hagihara M., Chargui J., Gansuvd B., et al. Umbilical cord blood T lymphocytes are induced to apoptosis after being allo-primed in vitro. Bone Marrow Transplant 24 (1999) 1229-1233
29. Park K.D., Marti L., Kurtzberg J., et al. In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naïve cord blood lymphocytes. Blood 108 (2006) 1770-1773