Discovery of novel P2Y14 agonist and antagonist using conventional and nonconventional methods

Journal of Biomolecular Screening

Volumn 16, Issue 9, 2011, Pages 1098-1105

  Hamel, Martine ^a   Henault, Martin ^a   Hyjazie, Huda ^a   Morin, Nicolas ^a   Bayly, Christopher ^a   Skorey, Kathryn ^a   Therien, Alex G ^a   Mancini, Joseph ^a   Brideau, Christine ^a   Kargman, Stacia ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

antagonist; GPCR; GPR105; P2Y14; UDP glucose

Indexed keywords

PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y14 RECEPTOR; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ARTICLE; BINDING ASSAY; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; EXPRESSION VECTOR; FLUOROMETRY; HUMAN; HUMAN CELL; IC 50; IMPEDANCE; MEMBRANE FILTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; LIGANDS; MICE; PAN TROGLODYTES; PROTEIN BINDING; PURINERGIC P2 RECEPTOR AGONISTS; PURINERGIC P2 RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 80053543466     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111415525     Document Type: Article

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