A tumor-environment-responsive nanocarrier that evolves its surface properties upon sensing matrix metalloproteinase-2 and initiates agglomeration to enhance T 2 relaxivity for magnetic resonance imaging

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1970-1974

  Matsumura, Sachiko ^a,b   Aoki, Ichio ^c   Saga, Tsuneo ^c   Shiba, Kiyotaka ^a  

^a CANCER INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

assembly; ferritin; magnetic resonance imaging; matrix metalloproteinases; protein nanoparticles; tumor

Indexed keywords

FERRIC HYDROXIDE; FERRITIN; GELATINASE A; MACROGOL; NANOCARRIER;

AQUEOUS SOLUTION; ARTICLE; ENZYME ACTIVITY; HYDROPHILICITY; HYDROPHOBICITY; IMAGING SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN MULTIMERIZATION; RELAXATION SENSATION; SURFACE PROPERTY; TUMOR MICROENVIRONMENT;

AMINO ACID SEQUENCE; ANIMALS; CONTRAST MEDIA; FERRIC COMPOUNDS; FERRITINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASE 2; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NEOPLASM PROTEINS; NEOPLASMS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; POLYETHYLENE GLYCOLS; SUBSTRATE SPECIFICITY; SURFACE PROPERTIES;

EID: 80053539005     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2001999     Document Type: Article

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