Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: A cross sectional study

Environmental Health: A Global Access Science Source

Volumn 10, Issue 1, 2011, Pages

  Ketelslegers, Hans B ^a   Godschalk, Roger Wl ^a   Gottschalk, Ralph Wh ^a   Knaapen, Ad M ^a   Koppen, Gudrun ^b   Schoeters, Greet ^b   Baeyens, Willy F ^c   Nelen, Vera ^d   Geraedts, Joep Pm ^e   Van Delft, Joost Hm ^a   Kleinjans, Jos Cs ^a   Van Larebeke, Nicolas A ^f  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d Provincial Institute of Hygiene   (Belgium)

^e MAASTRICHT UNIVERSITY   (Netherlands)

^f GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENCE; AGE STRUCTURE; ALLELE; DISEASE PREVALENCE; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENOTOXICITY; GENOTYPE; HEALTH RISK; MORBIDITY; MORTALITY; OBSERVATIONAL METHOD; OXIDATION; PHENOTYPE; POLYMORPHISM; POPULATION STRUCTURE; RISK FACTOR; SMOKING; SUBPOPULATION;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BELGIUM; CHRONIC DISEASE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA REPAIR; FEMALE; GENETIC POLYMORPHISM; GENOTOXICITY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; RISK; XENOBIOTIC METABOLISM; AGE; DNA DAMAGE; METABOLISM; MIDDLE AGED; PENETRANCE; RISK ASSESSMENT;

BELGIUM; FLANDERS;

XENOBIOTIC AGENT;

ADOLESCENT; AGE FACTORS; AGED; ALLELES; BELGIUM; CROSS-SECTIONAL STUDIES; DNA DAMAGE; DNA REPAIR; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PENETRANCE; POLYMORPHISM, GENETIC; PREVALENCE; RISK ASSESSMENT; XENOBIOTICS;

EID: 80053520530     PISSN: None     EISSN: 1476069X     Source Type: Journal    
DOI: 10.1186/1476-069X-10-85     Document Type: Article

References (58)

1. Mortality and morbidity trends: is there compression of morbidity? Crimmins EM, Beltran-Sanchez H, J Gerontol B Psychol Sci Soc Sci 2011 66 75 86 21135070
2. Cancer incidence among non-hispanic whites in the USA in the year, 2007 http://seer.cancer.gov/faststats/selections.php?#Output
3. Life-time risk of cancer in the USA. http://seer.cancer.gov/csr/1975- 2007/results-merged/topic-lifetime-risk.pdf
4. Cancer incidence in Flanders. http://www.kankerregister.org/
5. Mortality in function of age in Flanders. http://www.zorg-en gezondheid.be/Cijfers/Sterftecijfers/Algemene-sterftecijfers/ Sterftecijfers-per-leeftijd-sterfterisico-en-bevolkingspiramide/
6. The multitude and diversity of environmental carcinogens. Belpomme D, Irigaray P, Hardell L, Clapp R, Montagnier L, Epstein S, Sasco AJ, Environ Res 2007 105 414 429 10.1016/j.envres.2007.07.002 17692309 (Pubitemid 47554416)
7. Role of somatic mutations in vascular disease formation. Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Brunicardi FC, Gibbs RA, Chen C, Expert Rev Mol Diagn 2010 10 173 185 10.1586/erm.10.1 20214536
8. The role of genetic polymorphisms in environmental health. Kelada SN, Eaton DL, Wang SS, Rothman NR, Khoury MJ, Environ Health Perspect 2003 111 1055 1064 10.1289/ehp.6065 12826477 (Pubitemid 36826885)
9. Oxidative DNA damage, antioxidants, and cancer. Collins AR, Bioessays 1999 21 238 246 10.1002/(SICI)1521-1878(199903)21:3<238::AID-BIES8>3.0. CO;2-3 10333733 (Pubitemid 29172891)
10. Oxidative stress, human genetic variation, and disease. Forsberg L, de FU, Morgenstern R, Arch Biochem Biophys 2001 389 84 93 10.1006/abbi.2001.2295 11370676 (Pubitemid 32911546)
11. DNA repair fine structure and its relations to genomic instability. Bohr VA, Carcinogenesis 1995 16 2885 2892 10.1093/carcin/16.12.2885 8603460 (Pubitemid 26004182)
12. DNA damage repair and cardiovascular diseases. Shukla PC, Singh KK, Yanagawa B, Teoh H, Verma S, Can J Cardiol 2010 26 Suppl A 13A 16A 20386754
13. Environment and cancer: who are susceptible? Perera FP, Science 1997 278 1068 1073 10.1126/science.278.5340.1068 9353182 (Pubitemid 27517877)
14. Multiplex genotyping as a biomarker for susceptibility to carcinogenic exposure in the FLEHS biomonitoring study. Ketelslegers HB, Gottschalk RW, Koppen G, Schoeters G, Baeyens WF, van Larebeke NA, van Delft JHM, Kleinjans JCS, Cancer Epidemiol Biomarkers Prev 2008 17 1902 1912 10.1158/1055-9965.EPI- 08-0045 18708379
15. The quest for genetic determinants of human longevity: challenges and insights. Christensen K, Johnson TE, Vaupel JW, Nat Rev Genet 2006 7 436 448 10.1038/nrg1871 16708071 (Pubitemid 43780487)
16. A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival. Christiansen L, Brasch-Andersen C, Bathum L, Kruse TA, Christensen K, Mech Ageing Dev 2006 127 597 599 10.1016/j.mad.2006.02.003 16574194 (Pubitemid 43729537)
17. Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci. Muiras ML, Verasdonck P, Cottet F, Schachter F, Hum Genet 1998 102 526 532 10.1007/s004390050735 9654200 (Pubitemid 28282579)
18. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years. Taioli E, Gaspari L, Benhamou S, Boffetta P, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Dolzan V, Haugen A, Hirvonen A, Husgafvel-Pursiainen K, Kalina I, Kremers P, Le Marchand L, London S, Rannug A, Romkes M, Schoket B, Seidegard J, Strange RC, Stucker I, To-Figueras J, Garte S, Int J Epidemiol 2003 32 60 63 10.1093/ije/dyg001 12690010 (Pubitemid 36503475)
19. Distribution of glutathione S-transferase M1, P1 and T1 genotypes in different age-groups of Finns without diagnosed cancer. Voho A, Impivaara O, Jarvisalo J, Metsola K, Vainio H, Hirvonen A, Cancer Detect Prev 2006 30 144 151 10.1016/j.cdp.2005.11.004 16638627 (Pubitemid 43766237)
20. Internal exposure to pollutants measured in blood and urine of Flemish adolescents in function of area of residence. Schroijen C, Baeyens W, Schoeters G, Den HE, Koppen G, Bruckers L, Nelen V, Van De Mieroop E, Bilau M, Covaci A, Keune H, Loots I, Kleinjans J, Dhooge W, Van Larebeke N, Chemosphere 2008 71 1317 1325 10.1016/j.chemosphere.2007.11.053 18221770
21. Pollutant effects on genotoxic parameters and tumor-associated protein levels in adults: a cross sectional study. De Coster S, Koppen G, Bracke M, Schroijen C, Den HE, Nelen V, Van de Mieroop E, Bruckers L, Bilau M, Baeyens W, Schoeters G, van Larebeke N, Environ Health 2008 7 26 10.1186/1476-069X-7-26 18522717 (Pubitemid 351953038)
22. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Beyersmann D, Hartwig A, Arch Toxicol 2008 82 493 512 10.1007/s00204-008-0313-y 18496671
23. Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. Hartwig A, Asmuss M, Ehleben I, Herzer U, Kostelac D, Pelzer AT, Schwerdtle T, Bürkle A, Environ Health Perspect 2002 110 Suppl 5 797 799 12426134 (Pubitemid 35276869)
24. Genotoxic effects of lead: an updated review. Garcia-Leston J, Mendez J, Pasaro E, Laffon B, Environ Int 2010 36 623 636 10.1016/j.envint.2010.04.011 20466424
25. Advances in metal-induced oxidative stress and human disease. Jomova K, Valko M, Toxicology 2011 283 65 87 10.1016/j.tox.2011.03.001 21414382
26. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Silberhorn EM, Glauert HP, Robertson LW, Crit Rev Toxicol 1990 20 440 496 10.3109/10408449009029331 2165409
27. Metabolic gene polymorphism frequencies in control populations. Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, Autrup JL, Baranova H, Bathum L, Benhamou S, Boffetta P, Bouchardy C, Breskvar K, Brockmoller J, Cascorbi I, Clapper ML, Coutelle C, Daly A, Dell'Omo M, Dolzan V, Dresler CM, Fryer A, Haugen A, Hein DW, Hildesheim A, Hirvonen A, Hsieh L, Ingelman-Sundberg M, Kalina I, Kang D, Kihara M, et al. Cancer Epidemiol Biomarkers Prev 2001 10 1239 1248 11751440 (Pubitemid 34027754)
28. Simultaneous genotyping of nine polymorphisms in xenobiotic-metabolizing enzymes by multiplex PCR amplification and single base extension. Knaapen AM, Ketelslegers HB, Gottschalk RW, Janssen RG, Paulussen AD, Smeets HJ, Godschalk RWL, Van Schooten FJ, Kleinjans JCS, Van Delft JHM, Clin Chem 2004 50 1664 1668 10.1373/clinchem.2004.034058 15331501 (Pubitemid 39121237)
29. Ageing or cancer: a review on the role of caretakers and gatekeepers. van Heemst D, den Reijer PM, Westendorp RG, Eur J Cancer 2007 43 2144 2152 10.1016/j.ejca.2007.07.011 17764928 (Pubitemid 47539121)
30. Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. Bonafe M, Olivieri F, Mol Cell Endocrinol 2009 299 118 123 10.1016/j.mce.2008.10.038 19027825
31. Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population. Nishigaki Y, Fuku N, Tanaka M, Geriatr Gerontol Int 2010 10 Suppl 1 221 S235 20590837
32. [Polymorphism of cytokine genes and human longevity]. Mustafina OE, Pauk VV, Mustafina RS, Tuktarova IA, Nasibullin TR, Adv Gerontol 2010 23 339 345 21137202
33. 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. Naumova E, Ivanova M, Pawelec G, Constantinescu I, Bogunia-Kubik K, Lange A, Qguz F, Carin M, Franceschi C, Caruso C, Middleton D, Tissue Antigens 2011 77 187 192 10.1111/j.1399-0039.2010.01603.x 21299522
34. Role of genetic polymorphisms in myocardial infarction at young age. Incalcaterra E, Caruso M, Balistreri CR, Candore G, Lo PR, Hoffmann E, Caimi G, Clin Hemorheol Microcirc 2010 46 291 298 21187577
35. Neuroinflammation and Ageing: Current Theories and an Overview of the Data. Pizza V, Agresta A, D'Acunto CW, Festa M, Capasso A, Rev Recent Clin Trials 2011
36. Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction. Wilson MH, Grant PJ, Hardie LJ, Wild CP, FASEB J 2000 14 791 796 10744635 (Pubitemid 30198577)
37. Role of GSTT1 deletion in DNA oxidative damage by exposure to polycyclic aromatic hydrocarbons in humans. Garte S, Taioli E, Popov T, Kalina I, Sram R, Farmer P, Int J Cancer 2007 120 2499 2503 10.1002/ijc.22477 17330842 (Pubitemid 46642140)
38. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Hashibe M, Brennan P, Strange RC, Bhisey R, Cascorbi I, Lazarus P, Ophuis MB, Benhamou S, Foulkes WD, Katoh T, Coutelle C, Romkes M, Gaspari L, Taioli E, Boffetta P, Cancer Epidemiol Biomarkers Prev 2003 12 1509 1517 14693745 (Pubitemid 38031756)
39. Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. Taioli E, Mari D, Franceschi C, Bonafe M, Monti D, Bertolini S, Marinelli D, Garte S, Biochem Biophys Res Commun 2001 280 1389 1392 10.1006/bbrc.2001.4280 11162685 (Pubitemid 32917800)
40. CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions. Vineis P, Veglia F, Anttila S, Benhamou S, Clapper ML, Dolzan V, Ryberg D, Hirvonen A, Kremers P, Le Marchand L, Pastorelli R, Rannug A, Romkes M, Schoket B, Strange RC, Garte S, Taioli E, Biomarkers 2004 9 298 305 10.1080/13547500400011070 15764294 (Pubitemid 40089541)
41. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. Vineis P, Veglia F, Garte S, Malaveille C, Matullo G, Dunning AM, Peluso M, Airoldi L, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen JP, Kaaks R, Boeing H, Trichopoulou A, Palli D, Crosignani P, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros JR, Berglund G, Jarvholm B, et al. Ann Oncol 2007 18 1230 1242 10.1093/annonc/mdm109 17496311 (Pubitemid 47244371)
42. Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review. Raimondi S, Paracchini V, Autrup H, Barros-Dios JM, Benhamou S, Boffetta P, Cote ML, Dialyna IA, Dolzan V, Filiberti R, Garte S, Hirvonen A, Husgafvel-Pursiainen K, Imyanitov EN, Kalina I, Kang D, Kiyohara C, Kohno T, Kremers P, Lan Q, London S, Povey AC, Rannug A, Reszka E, Risch A, Romkes M, Schneider J, Seow A, Shields PG, Sobti RC, et al. Am J Epidemiol 2006 164 1027 1042 10.1093/aje/kwj321 17000715 (Pubitemid 44851738)
43. CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. Lee KM, Kang D, Clapper ML, Ingelman-Sundberg M, Ono-Kihara M, Kiyohara C, Min S, Lan Q, Le Marchand L, Lin P, Lung ML, Pinarbasi H, Pisani P, Srivatanakul P, Seow A, Sugimura H, Tokudome S, Yokota J, Taioli E, Cancer Epidemiol Biomarkers Prev 2008 17 1120 1126 10.1158/1055-9965.EPI-07-2786 18463401
44. Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease. Li R, Boerwinkle E, Olshan AF, Chambless LE, Pankow JS, Tyroler HA, Bray M, Pittman GS, Bell DA, Heiss G, Atherosclerosis 2000 149 451 462 10.1016/S0021-9150(99)00483-9 10729397 (Pubitemid 30145557)
45. Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype. Izzotti A, Cartiglia C, Lewtas J, De FS, FASEB J 2001 15 752 757 10.1096/fj.00-0312com 11259393 (Pubitemid 32245993)
46. Distributions of interleukin-6 (IL-6) promoter and metallothionein 2A (MT2A) core promoter region gene polymorphisms and their associations with aging in Turkish population. Kayaalti Z, Sahiner L, Durakoglugil ME, Soylemezoglu T, Arch Gerontol Geriatr 2011
47. Fine-particulate air pollution and life expectancy in the United States. Pope CA III, Ezzati M, Dockery DW, N Engl J Med 2009 360 376 386 10.1056/NEJMsa0805646 19164188
48. XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study. Betti M, Ferrante D, Padoan M, Guarrera S, Giordano M, Aspesi A, Mirabelli D, Casadio C, Ardissone CCF, Ruffini E, Betta PG, Libener R, Guaschino R, Matullo G, Piccolini E, Magnani C, Dianzani I, Mutat Res 2011 708 11 20 10.1016/j.mrfmmm.2011.01.001 21277872
49. [CYP1A1 polymorphisms, lack of glutathione S-transferase M1 (GSTM1), cooking oil fumes and lung cancer risk in non-smoking women]. Zhu XX, Hu CP, Gu QH, Zhonghua Jie He He Hu Xi Za Zhi 2010 33 817 822 21211368
50. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. Moore LE, Baris DR, Figueroa JD, Garcia-Closas M, Karagas MR, Schwenn MR, Johnson AT, Lubin JH, Hein DW, Dagnal CL, Colt JS, Kida M, Jones MA, Schned AR, Cherala SS, Chanock SJ, Cantor KP, Silverman N, Rothman N, Carcinogenesis 2011 32 182 189 10.1093/carcin/bgq223 21037224
51. Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers 2. Staessen JA, Nawrot T, Hond ED, Thijs L, Fagard R, Hoppenbrouwers K, Koppen G, Nelen V, Schoeters G, Vanderschueren D, Van Hecke E, Verschaeve L, Vlietinck R, Roels HA, Lancet 2001 357 1660 1669 10.1016/S0140-6736(00)04822-4 11425371 (Pubitemid 32568240)
52. Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose-response relationships. Dhooge W, den HE, Koppen G, Bruckers L, Nelen V, Van De Mieroop E, Bilau M, Kim Croes, Willy Baeyens, Greet Schoeters, Nicolas Van Larebeke, J Expo Sci Environ Epidemiol 2011 21 106 113 10.1038/jes.2009.63 20010975
53. Internal exposure to pollutants and body size in Flemish adolescents and adults: associations and dose-response relationships. Dhooge W, Den HE, Koppen G, Bruckers L, Nelen V, De Mieroop Van, Bilau M, Croes K, Baeyens W, Schoeters G, Van Larebeke N, Environ Int 2010 36 330 337 10.1016/j.envint.2010.01.005 20181395
54. The role of biotransformation in dietary (anti)carcinogenesis. van Iersel ML, Verhagen H, van Bladeren PJ, Mutat Res 1999 443 259 270 10415444 (Pubitemid 29327279)
55. Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. Agudo A, Sala N, Pera G, Capella G, Berenguer A, Garcia N, Palli D, Boeing H, Del Giudice G, Saieva C, Carneiro F, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Simán H, Stenling R, Hallmans G, Martínez C, Bilbao R, Barricarte A, Navarro C, Quirás JR, Allen N, Key T, Bingham S, Khaw KT, Linseisen J, Nagel G, et al. Cancer Epidemiol Biomarkers Prev 2006 15 2427 2434 10.1158/1055-9965.EPI-06-0072 17164366 (Pubitemid 46048300)
56. GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Hung RJ, Boffetta P, Brennan P, Malaveille C, Hautefeuille A, Donato F, Umberto Gelatti U, Spaliviero M, Placidi D, Carta A, Scotto di Carlo A, Porru S, Int J Cancer 2004 110 598 604 10.1002/ijc.20157 15122594 (Pubitemid 38658026)
57. Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. Laczmanska I, Gil J, Karpinski P, Stembalska A, Kozlowska J, Busza H, Trusewicz A, Pesz K, Ramsey D, Schlade-Bartusiak K, Blin N, Sasiadek MM, Environ Mol Mutagen 2006 47 666 673 10.1002/em.20253 17078101 (Pubitemid 44917678)
58. Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. Rotunno M, Yu K, Lubin JH, Consonni D, Pesatori AC, Goldstein AM, Goldin LR, Wacholder S, Welch R, Burdette L, Chanock SJ, Bertazzi PA, Tucker MA, Caporaso NE, Chatterjee N, Bergen AW, Landi MT, PLoS One 2009 4 5652 10.1371/journal.pone.0005652 19479063