Inhaled nitric oxide in preterm infants: An individual-patient data meta-analysis of randomized trials

Pediatrics

Volumn 128, Issue 4, 2011, Pages 729-739

  Askie, Lisa M ^a   Ballard, Roberta A ^b   Cutter, Gary R ^c   Dani, Carlo ^d   Elbourne, Diana ^e   Field, David ^f   Hascoet, Jean Michel ^g   Hibbs, Anna Maria ^h   Kinsella, John P ⁱ   Mercier, Jean Christophe ^j   Rich, Wade ^k   Schreiber, Michael D ^l   Wongsiridej, Pimol ^m   Subhedar, Nim V ⁿ   Van Meurs, Krisa P ^o   Voysey, Merryn ^a   Barrington, Keith ^p   Ehrenkranz, Richard A ^q   Finer, Neil N ^k  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d CAREGGI UNIVERSITY HOSPITAL   (Italy)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

^g Maternite Regionale Universitaire   (France)

^h CASE WESTERN RESERVE UNIVERSITY   (United States)

ⁱ Children's Hospital Colorado   (United States)

^j HÔPITAL ROBERT DEBRÉ   (France)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF CHICAGO   (United States)

^m MAHIDOL UNIVERSITY   (Thailand)

ⁿ LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

^o STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p UNIVERSITY OF MONTREAL   (Canada)

^q YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Chronic lung disease; Individual patient data meta analysis; Inhaled nitric oxide; Preterm infants; Respiratory disease

Indexed keywords

DEXAMETHASONE; NITRIC OXIDE; NITROGEN; OXYGEN; PLACEBO;

ASSISTED VENTILATION; CHRONIC LUNG DISEASE; DRUG EXPOSURE; GESTATION PERIOD; HUMAN; INFANT; META ANALYSIS; NEUROLOGIC DISEASE; PREMATURITY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY FAILURE; REVIEW; RISK ASSESSMENT; SURVIVAL RATE; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT INDICATION;

ADMINISTRATION, INHALATION; BRONCHODILATOR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LUNG INJURY; NITRIC OXIDE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATORY DISTRESS SYNDROME, NEWBORN; RISK; TREATMENT OUTCOME;

EID: 80053519757     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2010-2725     Document Type: Review

References (44)

1. Australian and New Zealand Neonatal Network. Report of the Australian and New Zealand Neonatal Network 2006. Sydney, Australia: Australian and New Zealand Neonatal Network; 2009
2. Furdon SA, Clark DA. Prematurity. Available at: http://emedicine. medscape.com/ article/975909-overview. Accessed March 16, 2010
3. Fanaroff AA, Stoll BJ, Wright LL, et al NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007;196(2):147.e1-147.e8
4. Bhandari A, Bhandari V. Bronchopulmonary dysplasia: an update. Indian J Pediatr. 2007; 74(1):73-77 (Pubitemid 47305192)
5. Schmidt B, Asztalos E, Roberts R, Robertson C, Sauve R, Whitfield M. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the Trial of Indomethacin Prophylaxis in Preterms. JAMA. 2003; 289(9):1124-1129 (Pubitemid 37430326)
6. Wood NS, Costeloe K, Gibson AT, Hennessy EM, Marlow N, Wilkinson AR. The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth. Arch Dis Child Fetal Neonatal Ed. 2005; 90(2):F134-F140 (Pubitemid 40333082)
7. Bennett FC, Scott DT. Long-term perspective on premature infant outcome and contemporary intervention issues. Semin Perinatol. 1997;21(3):190-201 (Pubitemid 27264180)
8. Bland R, Albertine K, Carlton D, MacRitchie A. Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs. Am J Respir Crit Care Med. 2005;172(7):899-906 (Pubitemid 41369075)
9. Hamon I, Fresson J, Nicolas MB, Buchweiller MC, Franck P, Hascoet JM. Early inhaled nitric oxide improves oxidative balance in very preterm infants. Pediatr Res. 2005; 57(5 pt 1):637-643 (Pubitemid 40578031)
10. Martin RJ, Mhanna MJ, Haxhiu MA. The role of endogenous and exogenous nitric oxide on airway function. Semin Perinatol. 2002; 26(6):432-438 (Pubitemid 36133542)
11. Cotton RB, Sundell HW, Zeldin DC, et al. Inhaled nitric oxide attenuates hyperoxic lung injury in lambs. Pediatr Res. 2006;59(1):142-146
12. McCurnin DC, Pierce RA, Chang LY, et al. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol. 2005;288(3):L450-L459 (Pubitemid 40229510)
13. Ballard PL, Gonzales LW, Godinez RI, et al. Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide. Pediatr Res. 2006;59(1):157-162
14. Balasubramaniam V, Maxey AM, Morgan DB, Markham NE, Abman SH. Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia. Am J Physiol Lung Cell Mol Physiol. 2006;291(1): L119-L127
15. Lin YJ, Markham NE, Balasubramaniam V, et al. Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats. Pediatr Res. 2005;58(1):22-29 (Pubitemid 40967424)
16. Maniscalco WM, Watkins RH, Pryhuber GS, Bhatt A, Shea C, Huyck H. Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons. Am J Physiol Lung Cell Mol Physiol. 2002;282(4):L811-L823 (Pubitemid 34665598)
17. Tang JR, Markham NE, Lin YJ, et al. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol. 2004;287(2):L344-L351 (Pubitemid 38943916)
18. Shaul PW, Afshar S, Gibson LL, et al. Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung. Am J Physiol Lung Cell Mol Physiol. 2002;283(6):L1192-L1199 (Pubitemid 35379251)
19. Ballard RA, Truog WE, Cnaan A, et al; NO CLD Study Group. Inhaled nitric oxide in preterm infants undergoing mechanical ventilation [published correction appears in N Engl J Med. 2007;357(14):1444-1445]. N Engl J Med. 2006;355(4):343-353 (Pubitemid 44127537)
20. The Franco-Belgium Collaborative NO Trial Group. Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomized controlled trial [published correction appears in Lancet. 1999;354(9192):1826]. Lancet. 1999;354(9184):1066-1071
21. Dani C, Bertini G, Pezzati M, Filippi L, Cecchi A, Rubaltelli FF. Inhaled nitric oxide in very preterm infants with severe respiratory distress syndrome. Acta Paediatr. 2006; 95(9):1116-1123 (Pubitemid 44385119)
22. Hascoet JM, Fresson J, Claris O, et al. The safety and efficacy of nitric oxide therapy in premature infants. J Pediatr. 2005;146(3): 318-323 (Pubitemid 40341739)
23. Field D, Elbourne D, Truesdale A, et al INNOVO Trial Collaborating Group. Neonatal ventilation with inhaled nitric oxide versus ventilatory support without inhaled nitric oxide for preterm infants with severe respiratory failure: the INNOVO multicentre randomised controlled trial. Pediatrics. 2005; 115(4):926-936
24. Kinsella JP, Cutter GR, Walsh WF, et al. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med. 2006;355(4):354-364 (Pubitemid 44127538)
25. Kinsella JP, Walsh WF, Bose CL, et al. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet. 1999; 354(9184):1061-1065 (Pubitemid 29452817)
26. Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med. 2003;349(22): 2099-2107 (Pubitemid 37464534)
27. Srisuparp P, Heitschmidt M, Schreiber MD. Inhaled nitric oxide therapy in premature infants with mild to moderate respiratory distress syndrome. J Med Assoc Thai. 2002; 85(suppl 2):S469-S478 (Pubitemid 35345817)
28. Subhedar N, Ryan S, Shaw N. Open randomized controlled trial of inhaled nitric oxide and early dexamethasone in high risk preterm infants. Arch Dis Child Fetal Neonatal Ed. 1997;77(3):F185-F190 (Pubitemid 28201582)
29. van Meurs K, Wright L, Ehrenkranz R, et al Preemie Inhaled Nitric Oxide Study. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med. 2005; 353(1):13-22 (Pubitemid 41007803)
30. van Meurs KP, Hintz SR, Ehrenkranz RA, et al. Inhaled nitric oxide in infants >1500 g and <34 weeks gestation with severe respiratory failure. J Perinatol. 2007;27(6):347-352 (Pubitemid 46860527)
31. Mercier JC, Hummler H, Durrmeyer X, et al. Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial. Lancet. 2010;376(9738):346-354
32. Su PH, Chen JY. Inhaled nitric oxide in the management of preterm infants with severe respiratory failure. J Perinatol. 2008; 28(2):112-116 (Pubitemid 351217637)
33. Barrington KJ, Finer N. Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane Database Syst Rev. 2010;(12): CD000509
34. Cools F, Askie LM, Offringa M, et al. Elective high-frequency oscillatory versus conventional ventilation in preterm infants: a systematic review and meta-analysis of individual patients' data. Lancet. 2010;375(9731): 2082-2091
35. Askie LM, Ballard RA, Cutter G, et al Metaanalysis of Preterm Patients on Inhaled Nitric Oxide (MAPPiNO) Collaboration. Inhaled nitric oxide in preterm infants: a systematic review and individual patient data metaanalysis. BMC Pediatr. 2010;10:15
36. Zou GA. Modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159(7):702-706
37. Follmann D, Proschan M, Leifer E. Multiple outputation: inference for complex clustered data by averaging analyses from independent data. Biometrics. 2003;59(2):420-429 (Pubitemid 36750356)
38. Ghersi D, Berlin J, Askie LM. Prospective meta-analysis. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Vol 5.0.1. Available at: www.cochrane-handbook.org. Accessed September 9, 2010
39. Ahluwalia J, Tooley J, Cheema I, et al. A dose response study of inhaled nitric oxide in hypoxic respiratory failure in preterm infants. Early Hum Dev. 2006;82(7):477-483 (Pubitemid 43963294)
40. Cole FS, Alleyne C, Barks JDE, et al. NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants. Pediatrics. 2011;127(2): 363-369
41. National Heart, Lung, and Blood Institute. Examining the use of non-invasive inhaled nitric oxide to reduce chronic lung disease in premature newborns. Available at: http://clinicaltrials.gov/ct2/ results?term=NCT00955487. Accessed September 9, 2010
42. INO Therapeutics. Inhaled nitric oxide (INO) for the prevention of bronchopulmonary dysplasia (BPD) in preterm infants. Available at: http://clinicaltrials.gov/ct2/ results?term=NCT00931632. Accessed September 9, 2010
43. University of Chicago. Inhaled nitric oxide and neuroprotection in premature infants (NOVA2). Available at: http://clinicaltrials. gov/ct2/results?term=NCT00515281. Accessed September 9, 2010
44. Donohue PK, Gilmore MM, Cristofalo E, et al. Inhaled nitric oxide in preterm infants: a systematic review. Pediatrics. 2011;127(2). Available at: www.pediatrics.org/cgi/content/full/127/2/e414