Two thiophenes compounds are partial peroxisome proliferator-activated receptor α/γ dual agonists

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 10, 2011, Pages 1631-1634

  Zheng, Zhihui ^a,b,c   Yang, Yi ^a   Shao, Huayi ^a   Liu, Zongying ^a   Lu, Xinhua ^c   Xu, Yanni ^a   He, Xiaobo ^a   Jiang, Wei ^a   Jiang, Qin ^c   Zhao, Baohua ^b   Zhang, Hua ^c   Li, Zhuorong ^a   Si, Shuyi ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b HEBEI NORMAL UNIVERSITY   (China)

^c North China Pharmaceutical Corporation   (China)

Author keywords

Peroxisome proliferator activated receptor; Proliferator activated receptor agonist; Proliferator activated receptor agonist; Thiophene; Type 2 diabetes mellitus

Indexed keywords

1 (BENZO[B]THIOPHEN 2 YL) 2 (METHYLSULFINYL)ETHANONE; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR ALPHA; GAL4 NUCLEAR RECEPTOR; IMB 05; IMB 15; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOID X RECEPTOR ALPHA; ROSIGLITAZONE; THENOYLTRIFLUOROACETONE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GLUCOSE HOMEOSTASIS; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; LIGAND BINDING; PARTIAL AGONISM; TRANSACTIVATION;

ANIMALS; CELL CULTURE TECHNIQUES; DIABETES MELLITUS, TYPE 2; DRUG EVALUATION, PRECLINICAL; GENES, REPORTER; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; MICE; MOLECULAR TARGETED THERAPY; PLASMIDS; PPAR ALPHA; PPAR GAMMA; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SULFOXIDES; THENOYLTRIFLUOROACETONE; THIAZOLIDINEDIONES; THIOPHENES;

EID: 80053497287     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1631     Document Type: Article

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