Hydrogen peroxide controls Akt activity via ubiquitination/degradation pathways

Oncology Reports

Volumn 26, Issue 6, 2011, Pages 1561-1566

  Kim, Sun Yong ^a,b   Bae, Seunghee ^b   Choi, Keun Hee ^c   An, Sungkwan ^b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Konkuk University   (South Korea)

^c Shinhan University   (South Korea)

Author keywords

Akt; Apoptosis; Hydrogen peroxide; Oxidative stress; Ubiquitination

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; HYDROGEN PEROXIDE; PROTEASOME; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYMATIC DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STABILITY; IN VIVO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; UBIQUITINATION;

ANIMALS; CELL SURVIVAL; ENZYME ACTIVATION; HYDROGEN PEROXIDE; OXIDANTS; OXIDATIVE STRESS; PC12 CELLS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; UBIQUITINATION;

EID: 80053490455     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1439     Document Type: Article

References (28)

1. Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418, 2000. (Pubitemid 32162623)
2. Halliwell B: Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: the key role of superoxide dismutase. Cell Biol Int Rep 2: 113-128, 1978.
3. Smith JA: Neutrophils, host defense, and inflammation: a double-edged sword. J Leukoc Biol 56: 672-686, 1994.
4. Chanock SJ, el Benna J, Smith RM and Babior BM: The respiratory burst oxidase. J Biol Chem 269: 24519-24522, 1994. (Pubitemid 24311695)
5. Pierce GB, Parchment RE and Lewellyn AL: Hydrogen peroxide as a mediator of programmed cell death in the blastocyst. Differentiation 46: 181-186, 1991.
6. Coffer PJ, Burgering BM, Peppelenbosch MP, Bos JL and Kruijer W: UV activation of receptor tyrosine kinase activity. Oncogene 11: 561-569, 1995.
7. Knebel A, Rahmsdorf HJ, Ullrich A and Herrlich P: Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J 15: 5314-5325, 1996. (Pubitemid 26336214)
8. Huang RP, Wu JX, Fan Y and Adamson ED: UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 133: 211-220, 1996. (Pubitemid 26107108)
9. Valko M, Morris H and Cronin MT: Metals, toxicity and oxidative stress. Curr Med Chem 12: 1161-1208, 2005. (Pubitemid 40655271)
10. Jenner P: Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol Biol (Paris) 44: 57-64, 1996.
11. Butterfield DA: Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences. Curr Med Chem 10: 2651-2659, 2003.
12. Rahman I, Morrison D, Donaldson K and MacNee W: Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 154: 1055-1060, 1996.
13. Franke TF: PI3K/Akt: getting it right matters. Oncogene 27: 6473-6488, 2008.
14. Vanhaesebroeck B and Alessi DR: The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346: 561-576, 2000. (Pubitemid 30171014)
15. Bhaskar PT and Hay N: The two TORCs and Akt. Dev Cell 12: 487-502, 2007. (Pubitemid 46523652)
16. Datta SR, Dudek H, Tao X, et al: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241, 1997. (Pubitemid 27456390)
17. Fujita E, Jinbo A, Matuzaki H, Konishi H, Kikkawa U and Momoi T: Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem Biophys Res Commun 264: 550-555, 1999. (Pubitemid 29516123)
18. Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995. (Pubitemid 26004411)
19. Brunet A, Bonni A, Zigmond MJ, et al: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868, 1999. (Pubitemid 29165088)
20. Peng XD, Xu PZ, Chen ML, et al: Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365, 2003.
21. Konishi H, Matsuzaki H, Tanaka M, et al: Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett 410: 493-498, 1997. (Pubitemid 27304124)
22. 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem J 336: 241-246, 1998.
23. Wang X, McCullough KD, Franke TF and Holbrook NJ: Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 275: 14624-14631, 2000. (Pubitemid 30339753)
24. 2 induce caspase-3-independent degradation of Akt/protein kinase B. J Biol Chem 277: 42943-42952, 2002.
25. Mann KK, Colombo M and Miller WH Jr: Arsenic trioxide decreases AKT protein in a caspase-dependent manner. Mol Cancer Ther 7: 1680-1687, 2008.
26. Orlowski M and Wilk S: Ubiquitin-independent proteolytic functions of the proteasome. Arch Biochem Biophys 415: 1-5, 2003. (Pubitemid 36687910)
27. Mani A and Gelmann EP: The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 23: 4776-4789, 2005. (Pubitemid 46224082)
28. Li YP, Chen Y, Li AS and Reid MB: Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes. Am J Physiol Cell Physiol 285: C806-C812, 2003. (Pubitemid 37158805)