Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors

Journal of Nuclear Medicine

Volumn 52, Issue 10, 2011, Pages 1638-1645

  Kimura, Yasuyuki ^a,b   Fujita, Masahiro ^a   Hong, Jinsoo ^a   Lohith, Talakad G ^a   Gladding, Robert L ^a   Zoghbi, Sami S ^a   Tauscher, Johannes A ^c   Goebl, Nancy ^c   Rash, Karen S ^c   Chen, Zhaogen ^c   Pedregal, Concepcion ^c   Barth, Vanessa N ^c   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Molecular imaging; Nociceptin orphanin peptide; Positron emission tomography

Indexed keywords

3 [2' FLUORO 6',7' DIHYDROSPIRO(PIPERIDINE 4,4' THIENO[3,2 C]PYRAN) 1 YL] 2 (2 FLUOROBENZYL) N METHYLPROPANAMIDE; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR ANTAGONIST; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BODY DISTRIBUTION; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG UPTAKE; HYPOTHALAMUS; MALE; NEOCORTEX; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION ABSORPTION; RADIATION EXPOSURE; RADIATION SAFETY; RECEPTOR BINDING; RHESUS MONKEY; WHOLE BODY IMAGING;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CARBON RADIOISOTOPES; CYCLOHEPTANES; HUMANS; MACACA MULATTA; MALE; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, OPIOID; SPIRO COMPOUNDS; WHOLE BODY IMAGING;

EID: 80053475230     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.091181     Document Type: Article

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