-
1
-
-
48949098573
-
Safety, efficacy, and biomarker findings of PBT2 in targeting A as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
-
Lannfelt L., Blennow K., Zetterberg H., Safety, efficacy, and biomarker findings of PBT2 in targeting A as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial The Lancet Neurology 2008 7 9 779 786
-
(2008)
The Lancet Neurology
, vol.7
, Issue.9
, pp. 779-786
-
-
Lannfelt, L.1
Blennow, K.2
Zetterberg, H.3
-
2
-
-
77954344206
-
PBT2 rapidly improves cognition in Alzheimer's disease: Additional phase II analyses
-
Faux N. G., Ritchie C. W., Gunn A., Rembach A., Tsatsanis A., Bedo J., Harrison J., Lannfelt L., Blennow K., Zetterberg H., Ingelsson M., Masters C. L., Tanzi R. E., Cummings J. L., Herd C. M., Bush A. I., PBT2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses Journal of Alzheimer's Disease 2010 20 2 509 516
-
(2010)
Journal of Alzheimer's Disease
, vol.20
, Issue.2
, pp. 509-516
-
-
Faux, N.G.1
Ritchie, C.W.2
Gunn, A.3
Rembach, A.4
Tsatsanis, A.5
Bedo, J.6
Harrison, J.7
Lannfelt, L.8
Blennow, K.9
Zetterberg, H.10
Ingelsson, M.11
Masters, C.L.12
Tanzi, R.E.13
Cummings, J.L.14
Herd, C.M.15
Bush, A.I.16
-
3
-
-
46149107512
-
Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
-
DOI 10.1016/j.neuron.2008.06.018, PII S0896627308005369
-
Adlard P. A., Cherny R. A., Finkelstein D. I., Gautier E., Robb E., Cortes M., Volitakis I., Liu X., Smith J. P., Perez K., Laughton K., Li Q. X., Charman S. A., Nicolazzo J. A., Wilkins S., Deleva K., Lynch T., Kok G., Ritchie C. W., Tanzi R. E., Cappai R., Masters C. L., Barnham K. J., Bush A. I., Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A Neuron 2008 59 1 43 55 (Pubitemid 351905863)
-
(2008)
Neuron
, vol.59
, Issue.1
, pp. 43-55
-
-
Adlard, P.A.1
Cherny, R.A.2
Finkelstein, D.I.3
Gautier, E.4
Robb, E.5
Cortes, M.6
Volitakis, I.7
Liu, X.8
Smith, J.P.9
Perez, K.10
Laughton, K.11
Li, Q.-X.12
Charman, S.A.13
Nicolazzo, J.A.14
Wilkins, S.15
Deleva, K.16
Lynch, T.17
Kok, G.18
Ritchie, C.W.19
Tanzi, R.E.20
Cappai, R.21
Masters, C.L.22
Barnham, K.J.23
Bush, A.I.24
more..
-
4
-
-
79952610782
-
Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease
-
Adlard P. A., Bica L., White A. R., Nurjono M., Filiz G., Crouch P. J., Donnelly P. S., Cappai R., Finkelstein D. I., Bush A. I., Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease PLoS ONE 2011 6 3
-
(2011)
PLoS ONE
, vol.6
, Issue.3
-
-
Adlard, P.A.1
Bica, L.2
White, A.R.3
Nurjono, M.4
Filiz, G.5
Crouch, P.J.6
Donnelly, P.S.7
Cappai, R.8
Finkelstein, D.I.9
Bush, A.I.10
-
5
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice
-
DOI 10.1073/pnas.2332818100
-
Bayer T. A., Schfer S., Simons A., Kemmling A., Kamer T., Tepest R., Eckert A., Schssel K., Eikenberg O., Sturchler-Pierrat C., Abramowski D., Staufenbiel M., Multhaup G., Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A production in APP23 transgenic mice Proceedings of the National Academy of Sciences of the United States of America 2003 100 2 14187 14192 (Pubitemid 37499212)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.SUPPL. 2
, pp. 14187-14192
-
-
Bayer, T.A.1
Schafer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schussel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
Abramowski, D.11
Staufenbiel, M.12
Multhaup, G.13
-
6
-
-
18244384051
-
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
-
DOI 10.1523/JNEUROSCI.0496-05.2005
-
Adlard P. A., Perreau V. M., Pop V., Cotman C. W., Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease Journal of Neuroscience 2005 25 17 4217 4221 (Pubitemid 40628765)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.17
, pp. 4217-4221
-
-
Adlard, P.A.1
Perreau, V.M.2
Pop, V.3
Cotman, C.W.4
-
7
-
-
76149093866
-
Cognitive loss in zinc transporter-3 knock-out mice: A phenocopy for the synaptic and memory deficits of Alzheimer's disease?
-
Adlard P. A., Parncutt J. M., Finkelstein D. I., Bush A. I., Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? Journal of Neuroscience 2010 30 5 1631 1636
-
(2010)
Journal of Neuroscience
, vol.30
, Issue.5
, pp. 1631-1636
-
-
Adlard, P.A.1
Parncutt, J.M.2
Finkelstein, D.I.3
Bush, A.I.4
-
8
-
-
21844448609
-
Amyloid-β oligomers are inefficiently measured by enzyme-linked immunosorbent assay
-
DOI 10.1002/ana.20524
-
Stenh C., Englund H., Lord A., Johansson A. S., Almeida C. G., Gellerfors P., Greengard P., Gouras G. K., Lannfelt L., Nilsson L. N. G., Amyloid- oligomers are inefficiently measured by enzyme-linked immunosorbent assay Annals of Neurology 2005 58 1 147 150 (Pubitemid 40962471)
-
(2005)
Annals of Neurology
, vol.58
, Issue.1
, pp. 147-150
-
-
Stenh, C.1
Englund, H.2
Lord, A.3
Johansson, A.-S.4
Almeida, C.G.5
Gellerfors, P.6
Greengard, P.7
Gouras, G.K.8
Lannfelt, L.9
Nilsson, L.N.G.10
-
9
-
-
33748476622
-
Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology
-
Sparks D. L., Friedland R., Petanceska S., Schreurs B. G., Shi J., Perry G., Smith M. A., Sharma A., Derosa S., Ziolkowski C., Stankovic G., Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology Journal of Nutrition, Health and Aging 2006 10 4 247 254 (Pubitemid 44351819)
-
(2006)
Journal of Nutrition, Health and Aging
, vol.10
, Issue.4
, pp. 247-254
-
-
Sparks, D.L.1
Friedland, R.2
Petanceska, S.3
Schreurs, B.G.4
Shi, J.5
Perry, G.6
Smith, M.A.7
Sharma, A.8
Derosa, S.9
Ziolkowski, C.10
Stankovic, G.11
-
10
-
-
33747204555
-
Dietary copper and high saturated and trans fat intakes associated with cognitive decline
-
DOI 10.1001/archneur.63.8.1085
-
Morris M. C., Evans D. A., Tangney C. C., Bienias J. L., Schneider J. A., Wilson R. S., Scherr P. A., Dietary copper and high saturated and trans fat intakes associated with cognitive decline Archives of Neurology 2006 63 8 1085 1088 (Pubitemid 44232313)
-
(2006)
Archives of Neurology
, vol.63
, Issue.8
, pp. 1085-1088
-
-
Morris, M.C.1
Evans, D.A.2
Tangney, C.C.3
Bienias, J.L.4
Schneider, J.A.5
Wilson, R.S.6
Scherr, P.A.7
-
11
-
-
8444227821
-
Reactive oxygen species and synaptic plasticity in the aging hippocampus
-
DOI 10.1016/j.arr.2004.05.002, PII S1568163704000303, Synaptic Function and Behavior During Normal Ageing
-
Serrano F., Klann E., Reactive oxygen species and synaptic plasticity in the aging hippocampus Ageing Research Reviews 2004 3 4 431 443 (Pubitemid 39487899)
-
(2004)
Ageing Research Reviews
, vol.3
, Issue.4
, pp. 431-443
-
-
Serrano, F.1
Klann, E.2
-
12
-
-
0141702360
-
Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
-
DOI 10.1073/pnas.1832769100
-
Sparks D. L., Schreurs B. G., Trace amounts of copper in water induce -amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2003 100 19 11065 11069 (Pubitemid 37140153)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.19
, pp. 11065-11069
-
-
Sparks, D.L.1
Schreurs, B.G.2
-
13
-
-
58549116872
-
Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway
-
Lu J., Wu D. M., Zheng Y. L., Sun D. X., Hu B., Shan Q., Zhang Z. F., Fan S. H., Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway Brain, Behavior, and Immunity 2009 23 2 193 203
-
(2009)
Brain, Behavior, and Immunity
, vol.23
, Issue.2
, pp. 193-203
-
-
Lu, J.1
Wu, D.M.2
Zheng, Y.L.3
Sun, D.X.4
Hu, B.5
Shan, Q.6
Zhang, Z.F.7
Fan, S.H.8
-
14
-
-
10744228112
-
In vivo reduction of amyloid-β by a mutant copper transporter
-
DOI 10.1073/pnas.2332851100
-
Phinney A. L., Drisaldi B., Schmidt S. D., Lugowski S., Coronado V., Liang Y., Horne P., Yang J., Sekoulidis J., Coomaraswamy J., Chishti M. A., Cox D. W., Mathews P. M., Nixon R. A., Carlson G. A., St. George-Hyslop P. P., Westaway D., In vivo reduction of amyloid- by a mutant copper transporter Proceedings of the National Academy of Sciences of the United States of America 2003 100 2 14193 14198 (Pubitemid 37499213)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.SUPPL. 2
, pp. 14193-14198
-
-
Phinney, A.L.1
Drisaldi, B.2
Schmidt, S.D.3
Lugowski, S.4
Coronado, V.5
Liang, Y.6
Horne, P.7
Yang, J.8
Sekoulidis, J.9
Coomaraswamy, J.10
Chishti, M.A.11
Cox, D.W.12
Mathews, P.M.13
Nixon, R.A.14
Carlson, G.A.15
St. George-Hyslop, P.16
Westaway, D.17
-
15
-
-
34147157711
-
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting β-amyloid burden
-
DOI 10.1523/JNEUROSCI.0059-07.2007
-
Malm T. M., Iivonen H., Goldsteins G., Keksa-Goldsteine V., Ahtoniemi T., Kanninen K., Salminen A., Auriola S., Van Groen T., Tanila H., Koistinaho J., Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting -amyloid burden Journal of Neuroscience 2007 27 14 3712 3721 (Pubitemid 46557689)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.14
, pp. 3712-3721
-
-
Malm, T.M.1
Iivonen, H.2
Goldsteins, G.3
Keksa-Goldsteine, V.4
Ahtoniemi, T.5
Kanninen, K.6
Salminen, A.7
Auriola, S.8
Van Groen, T.9
Tanila, H.10
Koistinaho, J.11
-
16
-
-
58849090893
-
Increasing Cu bioavailability inhibits A oligomers and tau phosphorylation
-
Crouch P. J., Lin W. H., Adlard P. A., Cortes M., Lal V., Filiz G., Perez K. A., Nurjono M., Caragounis A., Du T., Laughton K., Volitakis I., Bush A. I., Li Q. X., Masters C. L., Cappai R., Cherny R. A., Donnelly P. S., White A. R., Barnham K. J., Increasing Cu bioavailability inhibits A oligomers and tau phosphorylation Proceedings of the National Academy of Sciences of the United States of America 2009 106 2 381 386
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, Issue.2
, pp. 381-386
-
-
Crouch, P.J.1
Lin, W.H.2
Adlard, P.A.3
Cortes, M.4
Lal, V.5
Filiz, G.6
Perez, K.A.7
Nurjono, M.8
Caragounis, A.9
Du, T.10
Laughton, K.11
Volitakis, I.12
Bush, A.I.13
Li, Q.X.14
Masters, C.L.15
Cappai, R.16
Cherny, R.A.17
Donnelly, P.S.18
White, A.R.19
Barnham, K.J.20
more..
-
17
-
-
0037003044
-
D-penicillamine reduces serum oxidative stress in Alzheimer's disease patients
-
DOI 10.1046/j.1365-2362.2002.00933.x
-
Squitti R., Rossini P. M., Cassetta E., Moffa F., Pasqualetti P., Cortesi M., Colloca A., Rossi L., Finazzi-Agr A., D-penicillamine reduces serum oxidative stress in Alzheimer's disease patients European Journal of Clinical Investigation 2002 32 1 51 59 (Pubitemid 36228383)
-
(2002)
European Journal of Clinical Investigation
, vol.32
, Issue.1
, pp. 51-59
-
-
Squitti, R.1
Rossini, P.M.2
Cassetta, E.3
Moffa, F.4
Pasqualetti, P.5
Cortesi, M.6
Colloca, A.7
Rossi, L.8
Finazzi-Agro, A.9
-
18
-
-
57049180732
-
Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: A pilot phase 2 clinical trial
-
Kessler H., Pajonk F. G., Bach D., Schneider-Axmann T., Falkai P., Herrmann W., Multhaup G., Wiltfang J., Schfer S., Wirths O., Bayer T. A., Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial Journal of Neural Transmission 2008 115 12 1651 1659
-
(2008)
Journal of Neural Transmission
, vol.115
, Issue.12
, pp. 1651-1659
-
-
Kessler, H.1
Pajonk, F.G.2
Bach, D.3
Schneider-Axmann, T.4
Falkai, P.5
Herrmann, W.6
Multhaup, G.7
Wiltfang, J.8
Schfer, S.9
Wirths, O.10
Bayer, T.A.11
-
19
-
-
49749092065
-
Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: A pilot phase 2 clinical trial
-
Kessler H., Bayer T. A., Bach D., Schneider-Axmann T., Supprian T., Herrmann W., Haber M., Multhaup G., Falkai P., Pajonk F. G., Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial Journal of Neural Transmission 2008 115 8 1181 1187
-
(2008)
Journal of Neural Transmission
, vol.115
, Issue.8
, pp. 1181-1187
-
-
Kessler, H.1
Bayer, T.A.2
Bach, D.3
Schneider-Axmann, T.4
Supprian, T.5
Herrmann, W.6
Haber, M.7
Multhaup, G.8
Falkai, P.9
Pajonk, F.G.10
-
20
-
-
58549113169
-
Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease
-
Bica L., Crouch P. J., Cappai R., White A. R., Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease Molecular BioSystems 2009 5 2 134 142
-
(2009)
Molecular BioSystems
, vol.5
, Issue.2
, pp. 134-142
-
-
Bica, L.1
Crouch, P.J.2
Cappai, R.3
White, A.R.4
|