Spasmogenic and spasmolytic activities of Onosma griffithii Vatke

Pakistan Journal of Pharmaceutical Sciences

Volumn 24, Issue 4, 2011, Pages 553-558

  Ali, Niaz ^a,c   Ahmad, Bashir ^b   Ali Shah, Syed Wadood ^c  

^a KHYBER MEDICAL UNIVERSITY   (Pakistan)

^b UNIVERSITY OF PESHAWAR   (Pakistan)

^c UNIVERSITY OF MALAKAND   (Pakistan)

Author keywords

Calcium antagonists; EC 50; Onosma griffithii; spasmolytic; Spasmogenic

Indexed keywords

CALCIUM CHANNEL; CARBOHYDRATE; FLAVONOID; ONOSMIA GRIFFITHII EXTRACT; PLANT EXTRACT; SAPONIN; SPASMOGEN; SPASMOLYTIC AGENT; TERPENE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BORAGINACEAE; CONTROLLED STUDY; DRUG MECHANISM; NONHUMAN; ONOSMIA GRIFFITHII; PHYTOCHEMISTRY; RABBIT; SPASMOLYSIS;

ACETYLCHOLINE; ANIMALS; ATROPINE; BORAGINACEAE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHLORIDE; JEJUNUM; METHANOL; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; PARASYMPATHOMIMETICS; PLANT EXTRACTS; POTASSIUM CHLORIDE; RABBITS; SOLVENTS; VERAPAMIL;

EID: 80053447384     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Aduragbenro DA, Yeside OO, Adeolu AA, Olanrewaju MJ, Ayotunde SA, Olumayokun AO and Janet MM (2009). Blood pressure lowering effect of Adenantherapavonina Seed extract on normotensive rats. Rec. Nat. Prod., 3: 282-289.
2. Ali SI and Nasir YJ (1983). Onosma griffithii Vatke (Boraginaceae) (Eds.) In: Flora of Pakistan, Vol.191, Shamim Printing Press, Karachi p.103.
3. Ahmad I, Anis I, Malik A, Nawaz SA and Choudhary MI (2003). Cholinesterase Inhibitory Constituents from Onosma hispida. Chem. Pharm. Bull., 51(4): 412-414. (Pubitemid 41694816)
4. Ahmad I, Nawaz SA, Afza, N, Malik A, Fatima I, Sher Bahadar K, Ahmad M and Choudhary M Iqbal (2005). Isolation of Onosmins A and B, Lipoxygenase Inhibitors from Onosma hispida. Chem. Pharm. Bull., 53(8): 907-910. (Pubitemid 41327677)
5. Ahmad VU, Kousar F, Khan A, Zubair M, Iqbal S and Tareen RB (2005). A New Ketone and a known anticancer triterpenoid from the leaves of Onosma limitaneum. Helv. Chim. Acta., 88(2): 309-311. (Pubitemid 40380476)
6. Bashir A, Niaz A, Shumaila B, Choudhary MI, Sadiq A and Ibrar K (2009a). Parasiticidal, antifungal and antibacterial activities of Onosma griffithii Vatke. Afr. J. Biotechnol., 8(19): 5084-5087.
7. Bashir A, Niaz A, Shumaila B, Jamshaid A, Sadiq A and Ibrar K (2009b). Cholinomimetic and calcium channel blocking activity of Tylophora hirsuta Wall. J. Chem. Soc. Pak., 31(4): 647-651.
8. Cortes AR, Delgadillo AJ, Hurtado M, Dominguez- Ramirez AM, Medina JR and Aoki K (2006). The Antispasmodic Activity of Buddleja scordioides and Buddleja Perfoliata on isolated intestinal preparations. Biol. Pharm. Bull., 29(6): 1186-1190. (Pubitemid 43845480)
9. Edeoga HO, Okwu DE and Mbebie BO (2005). Phytochemical constituents of some Nigerian medicinal plants. Afr. J. Biotechnol., 4: 685-688. (Pubitemid 41032246)
10. ++ in myocardium, cardiac pacemakers and vascular smooth muscle. Rev. Pharmacol. Toxicol., 17: 149-166.
11. Ghayur MN and Gilani AH (2005). Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig. Dis. Sci., 50(10): 1889-1897. (Pubitemid 41413909)
12. Gilani AH, Bukhari IA, Khan RA, Khan A, Ullah F and Ahmad VU (2005). Cholinomimetic and calcium channel blocking activities of Carthamus oxycantha. Phytother.Res., 19: 679-683. (Pubitemid 41433631)
13. Gillespie JS and Mackenna BR (1960). The inhibitory action of nicotine on the rabbit colon. J. Physiol., 152: 191-205.
14. Harborne JB (1973). Phytochemical methods. Chapman and Hall, London, p.117.
15. Karaki H and Mitsui M (1988). Verapamil-sensitive and less sensitive contractions in the intestinal smooth muscle of guinea pig Taenia caeci. Jpn. J. Pharmacol.46 : 325-330.
16. 2+ release in smooth muscle. Physiological role of inositol 1,4,5-trisphosphate in lymphocytes. Indian J. Nat. Prod., 23(3): 8-12.
17. nd ed. Nirali Prakashan, Pune, Mumbai.
18. 2+ in the presence of ionophore A 23 187 in guinea-pig Tænia coli. Pharmacol. Res., 41(4): 397-403.
19. +2 on contraction of ileal longitudinal smooth muscle. Pharmacol. Res., 43(1): 95-102.
20. Niaz A, Bashir A, Shumaila B, Jehandar S, Sadiq A and Manzoor A (2009). Calcium channel blocking activities of Withania coagulans. Afr. J. Pharma. Pharmacol., 3(9): 43.
21. Niaz A and Wadood AS (2011). Antispasmodic activity of Teucrium stocksianum Bioss. Pak. J. Pharm. Sci., 24(2): 171-174.
22. Wadood AS, Samir K, Waqar A and Niaz A (2010). Spasmogenic, spasmolytic and antihypertensive activity of Forsskalea tenacissima L. Afr.J. Pharma. Pharmacol., 4(6): 381-385.
23. Shahina N (2005). Structure and functionality of the pigments isolated from Onosma hispidum (ratanjot) Terminalia catappa (jangli badam) and other tropical plant. Ph.D. thesis, University of Karachi, Karachi.
24. Sharma S, Khan N and Sultana S (2004). Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin. Life Sci., 75(20): 2391-2410. (Pubitemid 39180045)
25. Souza A and Aka K J (2007). Spasmogenic effect of the aqueous extract of Tamarindus indica L. (caesalpiniaceae) on the contractile activity of guineapig Taenia coli. Afr. J. Trad. CAM., 4(3): 261-266. (Pubitemid 46939505)
26. Tosun A, Akkol EK, Bahadir O and Yeilada E (2008). Evaluation of anti-inflammatory and antinociceptive activities of some Onosma L. species growing in Turkey. J. Ethnopharmacol., 120(3): 378-831.
27. Ufuk O, Maksut CK, Cavit K and Hasan SK (2004). Naphthoquinones from the Roots of Onosma argentatum Hub. (Boraginaceae). Turk. J. Chem., 28: 451-454.