Calcium channel blocking activities of Withania coagulans

African Journal of Pharmacy and Pharmacology

Volumn 3, Issue 9, 2009, Pages 439-442

  Ali, Niaz ^a   Ahmad, Bashir ^b   Bashir, Shumaila ^b   Shah, Jehandar ^a   Azam, Sadiq ^b   Ahmad, Manzoor ^a  

^a UNIVERSITY OF MALAKAND   (Pakistan)

^b UNIVERSITY OF PESHAWAR   (Pakistan)

Author keywords

Calcium channel blocking activity; Spasmolytic; Verapamil; Withania coagulans

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; PLANT EXTRACT; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; VERAPAMIL; WITHANIA COAGULANS EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG ACTIVITY; NONHUMAN; RABBIT; SMOOTH MUSCLE CONTRACTION; WITHANIA; WITHANIA COAGULANS;

EID: 77953679026     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Baker JT, Borris RP, Carte B, Cordell GA, Soejarto DD, Cragg GM, Upta MP, Iwu MM, Madulid DR, Tyler VE (1995). Natural product drug discovery and development: new perspectives on international collaboration. J. Nat. Prod. 58: 1325-1357.
2. Bolton TB (1979). Mechanism of action of transmitter and other substances on smooth muscles. Physiol. Rev. 59: 606-718.
3. Budhiraja RD, Sudhir S, Garg KN, Arora BC (1984). Antiinflammatory activity of 3-α-hydroxy-2, 3-dihydrowithanolide F. Planta Med. 50(2): 134-136.
4. Budhiraja RD, Sudhir S, Garg KN, Arora BC (1987). Review of biological activity of withanolides. J. Sci. Ind. Res. 46(11): 488-491.
5. Carl A, Lee HK, Sanders KM (1996). Regulation of ion channels in smooth muscles by calcium. (Invited Review). Am. J. Physiol. 271: C9-C34.
6. Chattopadhyay P, Mahaur K, Saha SK, Singh L, Shukla G, Wahi AK (2007). Effect of aqueous extract of fruits of Withania coagulans on cytotoxicity and tumor necrosis factor-α production in chicken.
7. Choudhary MI, Dur-e-Shahwar, Parveen Z, Jabbar A, Ali I, Atta-ur-Rahman (1995). Antifungal steroidal lactones from Withania coagulans. Phytochemistry 40(4): 1243-1246
8. Cortes AR, Delgadillo AJ, Hurtado M, Dominguez-Ramirez AM, Medina JR, Aoki K (2006).The Antispasmodic Activity of Buddleja scordioides and Buddleja Perfoliata on Isolated Intestinal Preparations. Biol. Pharm. Bull. 29(6): 1186-1190.
9. Enna SJ, Sullivan JP, Kenakin T, Fernaky JW, Porsolt RD, Williams M (2002). Protocols in isolated tissue. In Curr. Protoc. Pharmacol. John Wiley & Sons: New York 4(10): 1-4.
10. ++ antagonists. Gen. Pharmacol. 22: 177-181.
11. .. in myocardium, cardiac pacemakers and vascular smooth muscle. Rev. Pharmacol. Toxicol. 17: 149-166.
12. st.edn. New Awan Printers: Peshawar 4(16): 1-4.
13. Gaind KN, Budhiraja RD (1967). Antibacterial and anthelmintic activity of Withania coagulans. Indian J. Pharm. 29(6): 185-186.
14. Ghayur MN, Gilani AH (2005). Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Digestive Diseases and Sciences 50(10):1889-1897. (Pubitemid 41413909)
15. Gilani AH, Bukhari IA, Khan RA, Arif-ullah Khan, Farman Ullah, Viqar - U-Ahmad (2005). Cholinomimetic and Calcium Channel Blocking Activities of Carthamus oxycantha. Phytother. Res. 19: 679-683.
16. Godfraind T, Miller R, Wibo M (1986). Calcium antagonism and calcium entry blockade. Pharmacol. Rev. 38: 321-416.
17. Hemalatha S, Kumar R, Kumar M (2008). Withania coagulans Dunal: A Review. Pharmacognosy Reviews. Phcog. Rev. 2(4): 351-358.
18. Hemalatha S, Wahi AK, Singh PN, Chansouria JPN (2004). Hypoglycemic activity of Withania coagulans Dunal in streptozotocin induced diabetic rats. J. Ethnopharmacol. 93(2-3): 261-264.
19. Karaki H, Wiess G (1983). Mini-review: Calcium release in smooth muscles. Life Sci. 42: 111-112.
20. Khan MT, Ashraf M, Tehniyat S, Bukhtair MK, Ashraf S, Ahmad W (1993). Antibacterial activity of Withania coagulans. Fitoterapia. 64(4): 367-370
21. Kobayashi S, Kitazawa T, Somlyo AV, Somlyo AP (1989). Cytosolic heparin inhibits muscarinic and alpha-adrenergic Ca2+ release in smooth muscle. Physiological role of inositol 1,4,5-trisphosphate in lymphocytes. Indian J.Nat. Prod. 23(3): 8-12.
22. Olayiowola A (1984). WHO's traditional medicine programme: pharmacomechanical coupling. J. Biol. Chem. 264:17997-18004. progress and perspective. WHO Chronicle 38(2): 76-81.
23. Qayum A (2004). Isolated preparations. Guidelines and instructions. In: Rahman (1995). Antifungal steroidal lactones from Withania cagulans. Phytochem. 40(4): 1243-1246
24. Smith GM, Reynard AM (eds). W. B. Saunders Co: Philadelphia 453-479.
25. Triggle DJ, Smith GM, Reynard AM (1992). Drugs affecting calcium-regulation and actions. In Text Book of Pharmacology, (eds). W. B.
26. Van Rossum JM (1963). Cumulative dose- response curves II Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch. Int. Pharmacody. Ther. 143: 299-330.