Cholinomimetic and calcium channel blocking activities of Carthamus oxycantha

Phytotherapy Research

Volumn 19, Issue 8, 2005, Pages 679-683

  Gilani, Anwar H ^a   Bukhari, Ishfaq A ^b   Khan, Rafeeq A ^b   Khan, Arif Ullah ^a   Ullah, Farman ^b   Ahmad, Viqar U ^b  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Calcium antagonist; Carthamus oxycantha; Cholinergic; Spasmogenic; Spasmolytic

Indexed keywords

ACETIC ACID ETHYL ESTER; ATROPINE; CALCIUM CHANNEL BLOCKING AGENT; CARTHAMUS OXYCANTHA EXTRACT; CHLOROFORM; HEXANE; PLANT EXTRACT; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTHAMUS; CHOLINERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; GUINEA PIG; ILEUM; IN VITRO STUDY; JEJUNUM; MUSCLE RELAXATION; NONHUMAN; RABBIT; SPASMOLYSIS;

ANIMALS; BIOMIMETICS; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CARTHAMUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; ILEUM; JEJUNUM; MALE; MUSCLE CONTRACTION; PLANT EXTRACTS; RABBITS;

CARTHAMUS; CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS;

EID: 26444618516     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1727     Document Type: Article

References (22)

1. Baquar SR. 1989. Medicinal and Poisonous Plants of Pakistan. Printas: Karachi, 89.
2. Bocheva A, Mikhova B, Taskova R, Mitova M, Duddeck H. 2003. Antiinflammatory and analgesic effects of Carthamus lanatus aerial parts. Fitoterapia 74: 559-563.
3. Bolton TB. 1979. Mechanism of action of transmitter and other substances on smooth muscles. Physiol Rev 59: 606-718.
4. Brading AF. 1981. How do drugs initiate contractions in smooth muscles. Trends Pharmacol Sci 2: 261-265.
5. Brown JH, Taylor P. 1996. Muscarinic receptor agonists and antagonists. In Goodman & Gillman's The Pharmacological Basis of Therapeutics, 9th edn, Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG (eds). McGraw-Hill: New York, 141-159.
6. Duke JA. 1992. Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants. CRC Press: Tokyo, 137-140.
7. ++ antagonists. Gen Pharmacol 22: 177-181.
8. ++ in myocardium, cardiac pacemakers and vascular smooth muscle. Rev Pharmacol Toxicol 17: 149-166.
9. Gilani AH, Aftab K. 1992. Presence of acetylcholine substance(s) in Sesamum indicum. Arch Pharmacol Res 14: 3-6.
10. ++ channel blocking activity of Artemesia scoparia extract. Phytother Res 8: 161-165.
11. Gilani AH, Shaheen F, Christopoulos A, Mitchelson F. 1997. Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes. Life Sci 60: 535-544.
12. Godfraind T, Miller R, Wibo M. 1986. Calcium antagonism and calcium entry blockade. Pharmacol Rev 38: 321-416.
13. Karaki H, Wiess G. 1983. Mini-review: Calcium release in smooth muscles. Life Sci 42: 111-112.
14. Liu F, Wei Y, Yang XZ, Li FG, Hu J, Cheng RF. 1992. Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level. Yao Xue Xue Bao 27: 785-787.
15. +2 antagonist N-containing quinochalcone C-glycoside from Carthamus tinctorius. Chem Pharm Bull 40: 3355-3357.
16. Nadkarni KM. 1976. Indian Materia Medica, 3rd edn. Popular Prakashan: Bombay, 278-279.
17. National Research Council. 1996. Guide for the Care and Use of Laboratory Animals. National Academy Press: Washington, 1-7.
18. Taskova R, Mitova M, Najdenski H, Tzvetkova I, Duddeck H. 2002. Antimicrobial activity and cytotoxicity of Carthamus lanatus. Fitoterapia 73: 540-543.
19. Triggle DJ. 1992. Drugs affecting calcium-regulation and actions. In Text Book of Pharmacology, Smith GM, Reynard AM (eds). W. B. Saunders Co: Philadelphia, 453-479.
20. Usmanghani K, Saeed A, Alam MT. 1997. Indusyunic Medicine. University of Karachi Press: Karachi, 139-140.
21. Van Rossum JM. 1963. Cumulative dose-response curves. II. Techniques for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn Ther 143: 299-330.
22. Zhang HL, Nagatsu A, Watanabe T, Sakakibara J, Okuyama H. 1997. Antioxidative compounds isolated from safflower (Carthamus tinctorius) oil cake. Chem Pharm Bull 45: 1910-1914.