Chronic inorganic mercury exposure induces sex-specific changes in central TNFα expression: Importance in autism?

Neuroscience Letters

Volumn 504, Issue 1, 2011, Pages 40-44

  Thomas Curtis, J ^a   Chen, Yue ^a   Buck, Daniel J ^a   Davis, Randall L ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Autism; Chemokines; Cytokines; Environmental toxins; Heavy metals; Voles

Indexed keywords

MERCURY; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTISM; CEREBELLUM; FEMALE; HIPPOCAMPUS; IMMUNE RESPONSE; IN VIVO STUDY; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; VOLE;

ANIMALS; ARVICOLINAE; AUTISTIC DISORDER; CEREBELLUM; CHEMOKINE CCL2; CHEMOKINE CXCL10; FEMALE; HIPPOCAMPUS; MALE; MERCURY POISONING, NERVOUS SYSTEM; MODELS, ANIMAL; SEX CHARACTERISTICS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053446105     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.08.053     Document Type: Article

References (57)

1. Adler M.W., Geller E.B., Chen X., Rogers T.J. Viewing chemokines as a third major system of communication in the brain. AAPS J. 2006, 7:E865-E870.
2. Aragona B.J., Liu Y., Yu Y.J., Curtis J.T., Detwiler J.M., Insel T.R. Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. Nat. Neurosci. 2006, 9:133-139.
3. Ashwood P., Wills S., Van de Water J. The immune response in autism: a new frontier for autism research. J. Leukoc. Biol. 2006, 80:1-15.
4. Banisadr G., Gosselin R.D., Mechighel P., Rostene W., Kitabgi P., Melik Parsadaniantz S. Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. J. Comp. Neurol. 2005, 492:178-192.
5. Basu N., Scheuhammer A.M., Rouvinen-Watt K., Grochowina N., Evans R.D., O'Brien M., Chan H.M. Decreased N-methyl-D-aspartic acid (NMDA) receptor levels are associated with mercury exposure in wild and captive mink. Neurotoxicology 2007, 28:587-593.
6. Brown K.A. Factors modifying the migration of lymphocytes across the blood-brain barrier. Int. Immunopharmacol. 2001, 1:2043-2062.
7. Carpentier P.A., Begolka W.S., Olson J.K., Elhofy A., Karpus W.J., Miller S.D. Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 2005, 49:360-374.
8. Chertoff M., Di Paolo N., Schoeneberg A., Depino A., Ferrari C., Wurst W., Pfizenmaier K., Eisel U., Pitossi F. Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor alpha in the nigrostriatal dopaminergic circuit of adult mice. Exp. Neurol. 2011, 227:237-251.
9. Chez M.G., Dowling T., Patel P.B., Khanna P., Kominsky M. Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatr. Neurol. 2007, 36:361-365.
10. Cobb G.P., Moore A.W., Rummel K.T., Adair B.M., McMurry S.T., Hooper M.J. Mercury and methylmercury accumulation and excretion in prairie voles (Microtus ochrogaster) receiving chronic doses of methylmercury. Arch. Environ. Contam. Toxicol. 2007, 52:441-449.
11. Cohly H.H., Panja A. Immunological findings in autism. Int. Rev. Neurobiol. 2005, 71:317-341.
12. Counter S.A., Buchanan L.H. Mercury exposure in children: a review. Toxicol. Appl. Pharmacol. 2004, 198:209-230.
13. Curtis J.T., Hood A.N., Chen Y., Cobb G.P., Wallace D.R. Chronic metals ingestion by prairie voles produces sex-specific deficits in social behavior: an animal model of autism. Behav. Brain Res. 2010, 213:42-49.
14. Davis R.L., Buck D.J., Saffarian N., Stevens C.W. The opioid antagonist, beta-funaltrexamine, inhibits chemokine expression in human astroglial cells. J. Neuroimmunol. 2007, 186:141-149.
15. Davis R.L., Dertien J., Syapin P.J. Ethanol-induced modulation of inducible nitric-oxide synthase activity in human A172 astrocytoma cells. Alcohol Clin. Exp. Res. 2002, 26:1404-1411.
16. DeVries A.C., DeVries M.B., Taymans S.E., Carter C.S. The effects of stress on social preferences are sexually dimorphic in prairie voles. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:11980-11984.
17. Faro L.R., do Nascimento J.L., San Jose J.M., Alfonso M., Duran R. Intrastriatal administration of methylmercury increases in vivo dopamine release. Neurochem. Res. 2000, 25:225-229.
18. Franco J.L., Braga Hde C., Nunes A.K., Ribas C.M., Stringari J., Silva A.P., Garcia Pomblum S.C., Moro A.M., Bohrer D., Santos A.R., Dafre A.L., Farina M. Lactational exposure to inorganic mercury: evidence of neurotoxic effects. Neurotoxicol. Teratol. 2007, 29:360-367.
19. Gardner R.M., Nyland J.F., Evans S.L., Wang S.B., Doyle K.M., Crainiceanu C.M., Silbergeld E.K. Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ. Health Perspect. 2009, 117:1932-1938.
20. Garrecht M., Austin D.W. The plausibility of a role for mercury in the etiology of autism: a cellular perspective. Toxicol. Environ. Chem. 2011, 93:1251-1273.
21. Geier D.A., Kern J.K., Garver C.R., Adams J.B., Audhya T., Nataf R., Geier M.R. Biomarkers of environmental toxicity and susceptibility in autism. J. Neurol. Sci. 2009, 280:101-108.
22. Geier D.A., Kern J.K., Geier M.R. The biological basis of autism spectrum disorders: understanding causation and treatment by clinical geneticists. Acta Neurobiol. Exp. (Wars) 2010, 70:209-226.
23. Goncalves J., Baptista S., Martins T., Milhazes N., Borges F., Ribeiro C.F., Malva J.O., Silva A.P. Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin. Eur. J. Neurosci. 2010, 31:315-326.
24. Hewitson L., Lopresti B.J., Stott C., Mason N.S., Tomko J. Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study. Acta Neurobiol. Exp. (Wars) 2010, 70:147-164.
25. Hornig M., Chian D., Lipkin W.I. Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol. Psychiatry 2004, 9:833-845.
26. Insel T.R., Wang Z.X., Ferris C.F. Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents. J. Neurosci. 1994, 14:5381-5392.
27. Kempuraj D., Asadi S., Zhang B., Manola A., Hogan J., Peterson E., Theoharides T.C. Mercury induces inflammatory mediator release from human mast cells. J. Neuroinflamm. 2010, 7:20.
28. Kern J.K., Jones A.M. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J. Toxicol. Environ. Health B: Crit. Rev. 2006, 9:485-499.
29. Kim S.H., Johnson V.J., Sharma R.P. Mercury inhibits nitric oxide production but activates proinflammatory cytokine expression in murine macrophage: differential modulation of NF-kappaB and p38 MAPK signaling pathways. Nitric Oxide 2002, 7:67-74.
30. Kim S.H., Johnson V.J., Sharma R.P. Oral exposure to inorganic mercury alters T lymphocyte phenotypes and cytokine expression in BALB/c mice. Arch. Toxicol. 2003, 77:613-620.
31. Klein S.L., Bird B.H., Glass G.E. Sex differences in immune responses and viral shedding following Seoul virus infection in Norway rats. Am. J. Trop. Med. Hyg. 2001, 65:57-63.
32. Klein S.L., Cernetich A., Hilmer S., Hoffman E.P., Scott A.L., Glass G.E. Differential expression of immunoregulatory genes in male and female Norway rats following infection with Seoul virus. J. Med. Virol. 2004, 74:180-190.
33. Konigsberg M., Lopez-Diazguerrero N.E., Bucio L., Gutierrez-Ruiz M.C. Uncoupling effect of mercuric chloride on mitochondria isolated from an hepatic cell line. J. Appl. Toxicol. 2001, 21:323-329.
34. Laurente, Avalos B., Chiquinta J., Ponce B., Avendano R., Maya L. Neurotoxic effects of thimerosal at vaccines doses on the encephalon and development in 7 days-old hamsters. An Fac. Med. Lima 2007, 68:222-237.
35. Li X., Chauhan A., Sheikh A.M., Patil S., Chauhan V., Li X.M., Ji L., Brown T., Malik M. Elevated immune response in the brain of autistic patients. J. Neuroimmunol. 2009, 207:111-116.
36. Madrigal J.L., Leza J.C., Polak P., Kalinin S., Feinstein D.L. Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. J. Neurosci. 2009, 29:263-267.
37. Melik-Parsadaniantz S., Rostene W. Chemokines and neuromodulation. J. Neuroimmunol. 2008, 198:62-68.
38. Monnet-Tschudi F., Zurich M.G., Boschat C., Corbaz A., Honegger P. Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev. Environ. Health 2006, 21:105-117.
39. Mutter J., Curth A., Naumann J., Deth R., Walach H. Does inorganic mercury play a role in Alzheimer's disease? A systematic review and an integrated molecular mechanism. J. Alzheimers Dis. 2010, 22:357-374.
40. Mutter J., Naumann J., Schneider R., Walach H., Haley B. Mercury and autism: accelerating evidence?. Neuro Endocrinol. Lett. 2005, 26:439-446.
41. Nakajima A., Yamada K., Nagai T., Uchiyama T., Miyamoto Y., Mamiya T., He J., Nitta A., Mizuno M., Tran M.H., Seto A., Yoshimura M., Kitaichi K., Hasegawa T., Saito K., Yamada Y., Seishima M., Sekikawa K., Kim H.C., Nabeshima T. Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity. J. Neurosci. 2004, 24:2212-2225.
42. Noda M., Wataha J.C., Lockwood P.E., Volkmann K.R., Kaga M., Sano H. Sublethal, 2-week exposures of dental material components alter TNF-alpha secretion of THP-1 monocytes. Dent. Mater. 2003, 19:101-105.
43. Oh J.W., Schwiebert L.M., Benveniste E.N. Cytokine regulation of CC and CXC chemokine expression by human astrocytes. J. Neurovirol. 1999, 5:82-94.
44. Olczak M., Duszczyk M., Mierzejewski P., Meyza K., Majewska M.D. Persistent behavioral impairments and alterations of brain dopamine system after early postnatal administration of thimerosal in rats. Behav. Brain Res. 2011, 223:107-118.
45. Pamphlett R., Slater M., Thomas S. Oxidative damage to nucleic acids in motor neurons containing mercury. J. Neurol. Sci. 1998, 159:121-126.
46. Papp A., Nagymajtenyi L., Vezer T. Subchronic mercury treatment of rats in different phases of ontogenesis: functional effects on the central and peripheral nervous system. Food Chem. Toxicol. 2005, 43:77-85.
47. Pardo C.A., Vargas D.L., Zimmerman A.W. Immunity, neuroglia and neuroinflammation in autism. Int. Rev. Psychiatry 2005, 17:485-495.
48. Park K.M., Bowers W.J. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal 2010, 22:977-983.
49. Pickering M., Cumiskey D., O'Connor J.J. Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system. Exp. Physiol. 2005, 90:663-670.
50. Roos A., Neeft M., Engelen L., Schilder-Tol E.J., Kunzendorf U., Weening J.J., Aten J. The immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesion. Immunology 2001, 102:31-38.
51. Rossi A.D., Ahlbom E., Ogren S.O., Nicotera P., Ceccatelli S. Prenatal exposure to methylmercury alters locomotor activity of male but not female rats. Exp. Brain Res. 1997, 117:428-436.
52. Sui Y., Stehno-Bittel L., Li S., Loganathan R., Dhillon N.K., Pinson D., Nath A., Kolson D., Narayan O., Buch S. CXCL10-induced cell death in neurons: role of calcium dysregulation. Eur. J. Neurosci. 2006, 23:957-964.
53. Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 2005, 57:67-81.
54. Vezer T., Papp A., Kurunczi A., Parducz A., Naray M., Naggymajtenyi L. Behavioral and neurotoxic effects seen during and after subchronic exposure of rats to organic mercury. Environ. Toxicol. Pharmacol. 2005, 19:785-796.
55. Yao H., Peng F., Dhillon N., Callen S., Bokhari S., Stehno-Bittel L., Ahmad S.O., Wang J.Q., Buch S. Involvement of TRPC channels in CCL2-mediated neuroprotection against tat toxicity. J. Neurosci. 2009, 29:1657-1669.
56. Yasutake A., Marumoto M., Yoshida M. Neurotoxic action of inorganic mercury injected in the intraventricular space of mouse cerebrum. J. Toxicol. Sci. 2010, 35:767-771.
57. Young L.J., Pitkow L.J., Ferguson J.N. Neuropeptides and social behavior: animal models relevant to autism. Mol. Psychiatry 2002, 7(Suppl. 2):S38-S39.