Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1812, Issue 11, 2011, Pages 1412-1417

  Nur, Erfan ^a,b   Verwijs, Mirjam ^b   de Waart, Dirk R ^b   Schnog, John John B ^a,c   Otten, Hans Martin ^a   Brandjes, Dees P ^a   Biemond, Bart J ^b   Elferink, Ronald P J Oude ^b  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Sint Elisabeth Hospital   (Netherlands Antilles)

Author keywords

Glutathione; GSH; GSSG; Oxidative stress; Sickle cell disease

Indexed keywords

2,3 DIMETHOXY 1,4 NAPHTHOQUINONE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEMOGLOBIN; MULTIDRUG RESISTANCE PROTEIN 1; REACTIVE OXYGEN METABOLITE; VERLUKAST;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DETOXIFICATION; EFFUSION; ERYTHROCYTE COUNT; EXTRACELLULAR SPACE; FEMALE; GLUTATHIONE DEPLETION; GLUTATHIONE METABOLISM; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; INTRACELLULAR SPACE; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; OXIDATIVE STRESS; PRIORITY JOURNAL; SICKLE CELL;

ADULT; ANEMIA, SICKLE CELL; ANTIOXIDANTS; CASE-CONTROL STUDIES; ERYTHROCYTES; FEMALE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NAPHTHOQUINONES; PROPIONATES; QUINOLINES; YOUNG ADULT;

EID: 80053440770     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.04.011     Document Type: Article

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