Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease

Respiratory Research

Volumn 2, Issue 5, 2001, Pages 280-285

  Klings, Elizabeth S ^a   Farber, Harrison W ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute chest syndrome (ACS); Endothelium; Hemoglobin; Nitric oxide (NO); Oxidant stress

Indexed keywords

FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYL RADICAL; OXYGEN; PEROXYNITRITE; SUPEROXIDE;

ACUTE CHEST SYNDROME; BLOOD VESSEL INJURY; BLOOD VESSEL OCCLUSION; CELL INTERACTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ERYTHROCYTE; HUMAN; LEUKOCYTE; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; SICKLE CELL; SICKLE CELL ANEMIA; THROMBOCYTE; VASCULAR ENDOTHELIUM;

ANEMIA, SICKLE CELL; ANIMALS; ANTIOXIDANTS; ERYTHROCYTES; FREE RADICALS; HUMANS; LEUKOCYTES; OXIDANTS; THORAX;

EID: 0035722775     PISSN: 14659921     EISSN: None     Source Type: Journal    
DOI: 10.1186/rr70     Document Type: Review

References (63)

1. Pulmonary complications of sickle cell disease
2. Causes and outcomes of the acute chest syndrome in sickle cell disease
3. Status of myocardial antioxidants in ischemia-reperfusion injury
4. Sickle erythrocytes adhere to VCAM-1
5. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle cell mice but not in normal mice
6. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes
7. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells
8. Adaptive responses of the endothelium to stress
9. Peroxynitrite- induced membrane lipid peroxidation: The cytotoxic potential of nitric oxide and superoxide
10. Reperfusion injury pathophysiology in sickle transgenic mice
11. Peroxynitrite formation and apoptosis in transgenic sickle cell mouse kidneys
12. Reactive species in sickle cell disease
13. A novel phospholipid in irreversibly sickled cells: Evidence for in vivo peroxidative membrane damage in sickle cell disease
14. Spontaneous oxygen radical generation by sickle erythrocytes
15. Activated oxygen and haemolysis
16. Biology of disease: Free radicals and tissue injury
17. Oxidative hemoglobin denaturation and RBC destruction: The effect of heme on red cell membranes
18. The pecking order of free radicals and anti-oxidants: Lipid peroxidation, α-tocopherol, and ascorbate
19. Sickle cell membranes and oxidative damage
20. Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation of normal and sickled erythrocytes
21. Superoxide dismutases
22. 2 in erythrocytes
23. Altered amount and activity of superoxide dismutase in sickle cell anemia
24. Superoxide anion is involved in the breakdown of endothelial derived relaxing factor
25. Abnormal vitamin E and glutathione peroxidase levels in sickle cell anemia
26. An unusual pattern of neutrophil kinetics in sickle cell anemia
27. Mortality in sickle cell disease: Life expectancy and risk factors for early death
28. Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64
29. Neutrophil activation in sickle cell disease
30. Endothelial cell killing by neutrophils: Synergistic interaction of oxygen products and proteases
31. Transgenic HbS mouse neutrophils in increased susceptibility to acute lung injury
32. Elevated IL-8 levels during sickle cell crisis
33. Increased in vivo activation of neutrophils and complement in sickle cell disease
34. The release of nitric oxide and superoxide anion by neutrophils and mononuclear cells from patients with sickle cell anemia
35. Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst
36. Endothelial cell nitric oxide production in acute chest syndrome
37. Patterns of arginine and nitric oxide in sickle cell disease patients with vaso-occlusive crisis and acute chest syndrome
38. Sickle cell acute chest syndrome: Pathogenesis and rationale for treatment
39. The metabolites of nitric oxide in sickle cell disease
40. Nitric oxide metabolites in acute vasoocclusive crisis patients in the emergency department
41. Sequential nitric oxide measurements during the emergency room treatment of acute vasoocclusive sickle cell crisis
42. Inhibition of endothelium-dependent vasorelaxation by sickle erythrocytes
43. Mechanisms of stroke in sickle cell disease: Sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide inhibition
44. Nitric oxide regulation of tissue free radical injury
45. Endogenous nitric oxide: Physiology, pathology, and clinical relevance
46. Biosynthesis and action of nitric oxide in mammalian cells
47. Nitric oxide synthases: Which, where, how, and why?
48. Biochemistry of nitric oxide and its redox-activated forms
49. Kinetic analysis of the fate of nitric oxide synthesized by macrophages in vitro
50. Apparent hydroxyl radical production by peroxynitrite: Implications for injury from nitric oxide and superoxide
51. Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture
52. Endothelin-1 production during the acute chest syndrome of sickle cell disease
53. Oxidative stress as a regulator of gene expression in the vasculature
54. Antioxidant status and susceptibility of sickle erythrocytes to oxidative and osmotic stress
55. Low plasma pre-albumin and carotenoid levels in sickle cell disease patients
56. Serum vitamin E and the sickling status in children with sickle cell anaemia
57. Relationship of plasma alpha tocopherol to index of clinical severity in individuals with sickle cell anemia
58. A decrease in irreversibly sickle erythrocytes in sickle cell anemia patients given vitamin E
59. Selected indices of micronutrient status in adult patients with sickle cell anemia (SCA)
60. Plasma levels of retinol, ascorbic acid, and alpha-tocopherol in sickle cell anemia
61. Ascorbic acid in sickle cell disease: Results of a pilot therapeutic trial
62. Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease
63. Homocysteine in sickle cell disease: Relationship to stroke