The complex mechanism of glutamate dehydrogenase in insulin secretion

Diabetes

Volumn 60, Issue 10, 2011, Pages 2450-2454

  Fahien, Leonard A ^a   MacDonald, Michael J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; 3 HYDROXYACYL COENZYME A DEHYDROGENASE; CITRIC ACID; GLUTAMATE DEHYDROGENASE; GLUTAMINE; GUANOSINE TRIPHOSPHATE; LEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SIRTUIN 4;

ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HYPERINSULINISM; HYPOGLYCEMIA; INSULIN RELEASE; PRIORITY JOURNAL; REVIEW;

CITRIC ACID; DIABETES MELLITUS; GLUTAMATE DEHYDROGENASE; GLUTAMINE; HUMANS; INSULIN; ISLETS OF LANGERHANS; LEUCINE;

EID: 80053426332     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1150     Document Type: Review

References (47)

1. 2+. Mol Pharmacol 1990;37:943-949
2. Gylfe E. Comparison of the effects of leucines, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase. Acta Diabetol Lat 1976;13:20-24
3. Fahien LA, Teller JK. Glutamate-malate metabolism in liver mitochondria: a model constructed on the basis of mitochondrial levels of enzymes, specificity, dissociation constants, and stoichiometry of hetero-enzyme complexes. J Biol Chem 1992;267:10411-10422
4. Fahien LA, Kmiotek EH, Woldegiorgis G, Evenson M, Shrago E, Marshall M. Regulation of aminotransferase-glutamate dehydrogenase interactions by carbamyl phosphate synthase-I, Mg2+ plus leucine versus citrate and malate. J Biol Chem 1985;260:6069-6079 (Pubitemid 15072512)
5. Stanley CA, Lieu YK, Hsu BY, et al. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 1998;338:1352-1357 (Pubitemid 28216664)
6. Li C, Chen P, Palladino A, et al. Mechanism of hyperinsulinism in shortchain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem 2010;285:31806-31818
7. Llorente MD, Urrutia VJ. Diabetes, psychiatric disorders, and the metabolic effects of antipsychotic medications. Clin Diabetes 2006;24:18-24 (Pubitemid 43276936)
8. Shemisa OA, Fahien LA. Modifications of glutamate dehydrogenase by various drugs which affect behavior. Mol Pharmacol 1971;7:8-25
9. Haigis MC, Mostoslavsky R, Haigis KM, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells. Cell 2006;126:941-954 (Pubitemid 44321935)
10. Carobbio S, Frigerio F, Rubi B, et al. Deletion of glutamate dehydrogenase in β-cells abolishes part of the insulin secretory response not required for glucose homeostasis. J Biol Chem 2009;284:921-929
11. Cassman M, Schachman HK. Sedimentation equilibrium studies on glutamic dehydrogenase. Biochemistry 1971;10:1015-1024
12. Frieden C. Glutamic dehydrogenase. II. The effect of various nucleotides on the association-dissociation and kinetic properties. J Biol Chem 1959;234:815-820
13. Fahien LA, MacDonald MJ, Teller JK, Fibich B, Fahien CM. Kinetic advantages of hetero-enzyme complexes with glutamate dehydrogenase and the α-ketoglutarate dehydrogenase complex. J Biol Chem 1989;264:12303-12312 (Pubitemid 19191118)
14. Fahien LA, Smith SE. Interaction between glutamate dehydrogenase and transaminase. In Metabolic Interconversion of Enzymes. Fischer FH, Krebs EG, Neurath H, Stadtman ER, Eds. Berlin, Springer Verlag, 1974, p. 369-378
15. Fahien LA, Kmiotek EH, MacDonald MJ, Fibich B, Mandic M. Regulation of malate dehydrogenase activity by glutamate, citrate, α-ketoglutarate, and multienzyme interaction. J Biol Chem 1988;263:10687-10697
16. Fahien LA, Chobanian MC. Kinetic advantages of multienzyme complexes involving aminotransferases. In Channelling in Intermediary Metabolism. Agius L, Sherratt HAS, Eds. London, Portland Press, 1996, p. 219-236
17. Noyes BE, Glatthaar BE, Garavelli JS, Bradshaw RA. Structural and functional similarities between mitochondrial malate dehydrogenase and L-3-hydroxyacyl CoA dehydrogenase. Proc Natl Acad Sci USA 1974;71:1334-1338
18. Sener A, Malaisse-Lagae F, Malaisse WJ. Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci USA 1981;78:5460-5464 (Pubitemid 12248606)
19. Malaisse-Lagae F, Sener A, Garcia-Morales P, Valverde I, Malaisse WJ. The stimulus-secretion coupling of amino acid-induced insulin release: influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets. J Biol Chem 1982;257:3754-3758 (Pubitemid 12077153)
20. Cleland WW. Steady state kinetics. In The Enzymes. Vol II, 3rd ed. Boyer P, Ed. New York, Academic Press, 1970, p. 28-29
21. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem 1989;264:21608-21612 (Pubitemid 20028724)
22. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 1992;267:5802-5810
23. Hasan NM, Longacre MJ, Stoker SW, et al. Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase. J Biol Chem 2008;283:28048-28059
24. Fahien LA, MacDonald MJ, Kmiotek EH, Mertz RJ, Fahien CM. Regulation of insulin release by factors that also modify glutamate dehydrogenase. J Biol Chem 1988;263:13610-13614
25. Gylfe E. Glucose oxidation and contents of free amino acids in pancreatic beta-cells stimulated by a non-metabolizable leucine analogue. Biochim Biophys Acta 1974;343:584-589
26. Farfari S, Schulz V, Corkey B, Prentki M. Glucose-regulated anaplerosis and cataplerosis in pancreatic β-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 2000;49:718-726 (Pubitemid 30339986)
27. Pizarro-Delgado J, Braun M, Hernández-Fisac I, Martín-Del-Río R, Tamarit-Rodriguez J. Glucose promotion of GABA metabolism contributes to the stimulation of insulin secretion in β-cells. Biochem J 2010;431:381-389
28. MacDonald MJ, Fahien LA. Insulin release in pancreatic islets by a glycolytic and a Krebs cycle intermediate: contrasting patterns of glyceraldehyde phosphate and succinate. Arch Biochem Biophys 1990;279:104-108 (Pubitemid 20149779)
29. MacDonald MJ, Fahien LA, Buss JD, Hasan NM, Fallon MJ, Kendrick MA. Citrate oscillates in liver and pancreatic beta cell mitochondria and in INS-1 insulinoma cells. J Biol Chem 2003;278:51894-51900 (Pubitemid 38020436)
30. Feliss N, Martinez-Carrion M. The molecular weight and subunits of the isozymes of glutamic aspartic transaminase. Biochem Biophys Res Commun 1970;40:932-940
31. Srivastava DK, Bernhard SA. Enzyme-enzyme interactions and the regulation of metabolic reaction pathways. Curr Top Cell Regul 1986;28:1-68
32. Iwatsubo M, Pantaloni D. Regulation of the activity of glutamate dehydrogenase by effectors GTP and ADP: study by means of "stopped flow". Bull Soc Chim Biol (Paris) 1967;49:1563-1572 [in French]
33. Fahien LA, MacDonald MJ. The succinate mechanism of insulin release. In Commentaries on Perspectives in Diabetes Volume 3 (1998-2002). Robertson RP, Ed. New York, McGraw-Hill, 2007, p. 2669-2676
34. Smith BC, Clotfelter LA, Cheung JY, LaNoue KF. Differences in 2-oxoglutarate dehydrogenase regulation in liver and kidney. Biochem J 1992;284:819-826
35. Teller JK, Fahien LA, Valdivia E. Interactions among mitochondrial aspartate aminotransferase, malate dehydrogenase, and the inner mitochondrial membrane from heart, hepatoma, and liver. J Biol Chem 1990;265:19486-19494 (Pubitemid 120013890)
36. Fahien LA, Strmecki M, Smith S. Studies of gluconeogenic mitochondrial enzymes. I. A new method of preparing bovine liver glutamate dehydrogenase and effects of purification methods on properties of the enzyme. Arch Biochem Biophys 1969;130:449-455
37. King KS, Frieden C. The purification and physical properties of glutamate dehydrogenase from rat liver. J Biol Chem 1970;245:4391-4396
38. Fahien LA, Hsu SL, Kmiotek E. Effect of aspartate on complexes between glutamate dehydrogenase and various aminotransferases. J Biol Chem 1977;252:1250-1256 (Pubitemid 8047882)
39. Pepin E, Guay C, Delghingaro-Augusto V, Joly E, Madiraju SR, Prentki M. Short-chain 3-hydroxyacyl-CoA dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in INS832/13 β-cells. J Diabetes 2010;2:157-167
40. Fahien LA, Kmiotek E. Regulation of glutamate dehydrogenase by palmitoylcoenzyme A. Arch Biochem Biophys 1981;212:247-253
41. Kawaguchi A, Bloch K. Inhibition of glutamate dehydrogenase and malate dehydrogenases by palmitoyl coenzyme A. J Biol Chem 1976;251:1406-1412
42. Pal PK, Colman RF. Affinity labeling of an allosteric GTP site of bovine liver glutamate dehydrogenase by 5′-p-fluorosulfonylbenzoylguanosine. Biochemistry 1979;18:838-845
43. McGarry JD, Foster DW. Interrelations between fatty acid synthesis, fatty acid oxidation and ketogenesis in liver. In Microenvironments and Metabolic Compartmentation. Srere PA, Estabrook RW, Eds. New York, Academic Press, 1978, p. 245-260
44. Colman RF, Foster DS. The absence of zinc in bovine liver glutamate dehydrogenase. J Biol Chem 1970;245:6190-6195
45. Anderson TPO, Berggren A, Flatt PR. Subcellular distribution of zinc in islet beta-cell fractions. Horm Metab Res 1980;12:275-276 (Pubitemid 10123150)
46. MacDonald MJ, Hasan NM, Longacre MJ. Studies with leucine, betahydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion. Biochim Biophys Acta 2008;1780:966-972
47. MacDonald MJ, Smith AD 3rd, Hasan NM, Sabat G, Fahien LA. Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell. J Biol Chem 2007;282:30596-30606 (Pubitemid 350035194)