Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease

Blood Cells, Molecules, and Diseases

Volumn 47, Issue 3, 2011, Pages 143-157

  Leecharoenkiat, Amporn ^a   Wannatung, Tirawat ^a   Lithanatudom, Pathrapol ^a   Svasti, Saovaros ^a   Fucharoen, Suthat ^a   Chokchaichamnankit, Daranee ^b   Srisomsap, Chantragan ^b   Smith, Duncan R ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Krung Thep Maha Nakhon   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CELL PROTEIN; CITRIC ACID; COPROPORPHYRINOGEN OXIDASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DELTA GLOBIN; ELONGATION FACTOR TU; ENOLASE 1 ALPHA; FLAVIN REDUCTASE; FRUCTOSE BISPHOSPHATE ALDOLASE; FUMARASE PRECURSOR; GLUCOSIDASE; GLUTATHIONE TRANSFERASE OMEGA 1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C2; LACTATE DEHYDROGENASE A ISOFORM 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXIREDOXIN 2; PHOSPHOGLYCERATE MUTASE 1; PROTEASOME ACTIVATOR SUBUNIT 1 ISOFORM 1; PROTEIN KINASE B; PROTEIN KINASE C; SELENIUM BINDING PROTEIN; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; UROPORPHYRINOGEN DECARBOXYLASE;

ADOLESCENT; ADULT; AEROBIC METABOLISM; ARTICLE; BETA THALASSEMIA; CD34 SELECTION; CELL DIFFERENTIATION; CELL EXPANSION; CELL MATURATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ERYTHROBLAST; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEOMICS; UPREGULATION; WESTERN BLOTTING;

ADOLESCENT; ADULT; APOPTOSIS; BETA-THALASSEMIA; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; ENZYME ACTIVATION; ERYTHROBLASTS; ERYTHROPOIESIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLYCOLYSIS; HEMOGLOBIN E; HUMANS; K562 CELLS; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEOMICS; REACTIVE OXYGEN SPECIES; U937 CELLS;

EID: 80053386941     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.06.005     Document Type: Article

References (53)

1. Olivieri N.F. The beta-thalassemias. N Engl J. Med. 1999, 341:99-109.
2. Yuan J., Angelucci E., Lucarelli G., Aljurf M., Snyder L.M., Kiefer C.R., Ma L., Schrier S.L. Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia). Blood 1993, 82:374-377.
3. Mathias L.A., Fisher T.C., Zeng L., Meiselman H.J., Weinberg K.I., Hiti A.L., Malik P. Ineffective erythropoiesis in beta-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage. Exp. Hematol. 2000, 28:1343-1353.
4. Poyart C., Wajcman H. Hemolytic anemias due to hemoglobinopathies. Mol. Aspects Med. 1996, 17:129-142.
5. Centis F., Tabellini L., Lucarelli G., Buffi O., Tonucci P., Persini B., Annibali M., Emiliani R., Iliescu A., Rapa S., Rossi R., Ma L., Angelucci E., Schrier S.L. The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major. Blood 2000, 96:3624-3629.
6. Chaisiripoomkere W., Jootar S., Chanjarunee S., Ungkanont A. Serum erythropoietin levels in thalassemia major and intermedia. Southeast Asian J. Trop. Med. Public Health 1999, 30:786-788.
7. Nisli G., Kavakli K., Aydinok Y., Oztop S., Cetingul N. Serum erythropoietin levels in patients with beta thalassemia major and intermedia. Pediatr. Hematol. Oncol. 1997, 14:161-167.
8. Paritpokee N., Wiwanitkit V., Bhokaisawan N., Boonchalermvichian C., Preechakas P. Serum erythropoietin levels in pediatric patients with beta-thalassemia/hemoglobin E. Clin. Lab. 2002, 48:631-634.
9. Fucharoen S., Winichagoon P. Clinical and hematologic aspects of hemoglobin E beta-thalassemia. Curr. Opin. Hematol. 2000, 7:106-112.
10. Rees D.C., Styles L., Vichinsky E.P., Clegg J.B., Weatherall D.J. The hemoglobin E syndromes. Ann. N. Y. Acad. Sci. 1998, 850:334-343.
11. Haseyama Y., Sawada K., Oda A., Koizumi K., Takano H., Tarumi T., Nishio M., Handa M., Ikeda Y., Koike T. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. Blood 1999, 94:1568-1577.
12. Klingmuller U. The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells-signals emanating from the erythropoietin receptor. Eur. J. Biochem. 1997, 249:637-647.
13. Myklebust J.H., Smeland E.B., Josefsen D., Sioud M. Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow. Blood 2000, 95:510-518.
14. Oda A., Sawada K., Druker B.J., Ozaki K., Takano H., Koizumi K., Fukada Y., Handa M., Koike T., Ikeda Y. Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors. Blood 1998, 92:443-451.
15. Schmidt E.K., Fichelson S., Feller S.M. PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors. BMC Biol. 2004, 2:7.
16. Sui X., Krantz S.B., You M., Zhao Z. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis. Blood 1998, 92:1142-1149.
17. Wannatung T., Lithanatudom P., Leecharoenkiat A., Svasti S., Fucharoen S., Smith D.R. Increased erythropoiesis of beta-thalassaemia/Hb E proerythroblasts is mediated by high basal levels of ERK1/2 activation. Br. J. Haematol. 2009, 146:557-568.
18. Libani I.V., Guy E.C., Melchiori L., Schiro R., Ramos P., Breda L., Scholzen T., Chadburn A., Liu Y., Kernbach M., Baron-Luhr B., Porotto M., de Sousa M., Rachmilewitz E.A., Hood J.D., Cappellini M.D., Giardina P.J., Grady R.W., Gerdes J., Rivella S. Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood 2008, 112:875-885.
19. Sripichai O., Makarasara W., Munkongdee T., Kumkhaek C., Nuchprayoon I., Chuansumrit A., Chuncharunee S., Chantrakoon N., Boonmongkol P., Winichagoon P., Fucharoen S. A scoring system for the classification of beta-thalassemia/Hb E disease severity. Am. J. Hematol. 2008, 83:482-484.
20. Langlois S., Ford J.C., Chitayat D., Desilets V.A., Farrell S.A., Geraghty M., Nelson T., Nikkel S.M., Shugar A., Skidmore D., Allen V.M., Audibert F., Blight C., Gagnon A., Johnson J.A., Wilson R.D., Wyatt P. Carrier screening for thalassemia and hemoglobinopathies in Canada. J. Obstet. Gynaecol. Can. 2008, 30:950-971.
21. Lithanatudom P., Leecharoenkiat A., Wannatung T., Svasti S., Fucharoen S., Smith D.R. A mechanism of ineffective erythropoiesis in beta-thalassemia/Hb E disease. Haematologica 2010, 95:716-723.
22. Choi I., Muta K., Wickrema A., Krantz S.B., Nishimura J., Nawata H. Interferon gamma delays apoptosis of mature erythroid progenitor cells in the absence of erythropoietin. Blood 2000, 95:3742-3749.
23. Amer J., Goldfarb A., Fibach E. Flow cytometric measurement of reactive oxygen species production by normal and thalassaemic red blood cells. Eur. J. Haematol. 2003, 70:84-90.
24. Srisomsap C., Sawangareetrakul P., Subhasitanont P., Chokchaichamnankit D., Chiablaem K., Bhudhisawasdi V., Wongkham S., Svasti J. Proteomic studies of cholangiocarcinoma and hepatocellular carcinoma cell secretomes. J. Biomed. Biotechnol. 2010, 437143.
25. Klein E., Ben-Bassat H., Neumann H., Ralph P., Zeuthen J., Polliack A., Vanky F. Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia. Int. J. Cancer 1976, 18:421-431.
26. McGrath K.E., Bushnell T.P., Palis J. Multispectral imaging of hematopoietic cells: where flow meets morphology. J. Immunol. Meth. 2008, 336:91-97.
27. Campbell M.K., Farrell S.O. Biochemistry 2009, Thomson-Brooks/Cole, Belmont.
28. Amer J., Fibach E. Oxidative status of platelets in normal and thalassemic blood. Thromb. Haemost. 2004, 92:1052-1059.
29. Amer J., Goldfarb A., Fibach E. Flow cytometric analysis of the oxidative status of normal and thalassemic red blood cells. Cytom. A 2004, 60:73-80.
30. Prus E., Fibach E. Effect of iron chelators on labile iron and oxidative status of thalassaemic erythroid cells. Acta Haematol. 2010, 123:14-20.
31. Scott M.D. H2O2 injury in beta thalassemic erythrocytes: protective role of catalase and the prooxidant effects of GSH. Free Radic. Biol. Med. 2006, 40:1264-1272.
32. Wrona M., Patel K.B., Wardman P. The roles of thiol-derived radicals in the use of 2',7'-dichlorodihydrofluorescein as a probe for oxidative stress. Free Radic. Biol. Med. 2008, 44:56-62.
33. Chen J.S., Lin K.H., Tsao C.J. Peripheral blood hematopoietic progenitor cells in beta-thalassemia major. Int. J. Cell Cloning 1992, 10:338-343.
34. Yaowaree K., Monnipha S.-a., Ahnond B. Enhanced maturation and proliferation of β-thalassemia/hb e erythroid precursor cells in culture. Southeast Asian J Trop. Med. Public Health (SJTMAK) 2005, 36:1298-1303.
35. Richardson B.M., Heesom K.J., Parsons S.F., Anstee D.J., Frayne J. Analysis of the differential proteome of human erythroblasts during in vitro erythropoiesis by 2-D DIGE. Proteomics - Clin. Appl. 2009, 3:1123-1134.
36. Brookes P.S., Yoon Y., Robotham J.L., Anders M.W., Sheu S.S. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am. J. Physiol. Cell Physiol. 2004, 287:C817-C833.
37. Dhar-Chowdhury P., Malester B., Rajacic P., Coetzee W.A. The regulation of ion channels and transporters by glycolytically derived ATP. Cell. Mol. Life Sci. 2007, 64:3069-3083.
38. Bilbao P.S., Santillan G., Boland R. ATP stimulates the proliferation of MCF-7 cells through the PI3K/Akt signaling pathway. Arch. Biochem. Biophys. 2010, 499:40-48.
39. Nunes P.H., Calaza Kda C., Albuquerque L.M., Fragel-Madeira L., Sholl-Franco A., Ventura A.L. Signal transduction pathways associated with ATP-induced proliferation of cell progenitors in the intact embryonic retina. Int. J. Dev. Neurosci. 2007, 25:499-508.
40. Violin J.D., Zhang J., Tsien R.Y., Newton A.C. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J. Cell Biol. 2003, 161:899-909.
41. Arciuch V.G., Alippe Y., Carreras M.C., Poderoso J.J. Mitochondrial kinases in cell signaling: facts and perspectives. Adv. Drug Deliv. Rev. 2009, 61:1234-1249.
42. Blanc A., Pandey N.R., Srivastava A.K. Distinct roles of Ca2+, calmodulin, and protein kinase C in H2O2-induced activation of ERK1/2, p38 MAPK, and protein kinase B signaling in vascular smooth muscle cells. Antioxid. Redox Signal. 2004, 6:353-366.
43. Gopalakrishna R., Jaken S. Protein kinase C signaling and oxidative stress. Free Radic. Biol. Med. 2000, 28:1349-1361.
44. Larsson R., Cerutti P. Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants. Cancer Res. 1989, 49:5627-5632.
45. O'Flaherty C., de Lamirande E., Gagnon C. Reactive oxygen species and protein kinases modulate the level of phospho-MEK-like proteins during human sperm capacitation. Biol. Reprod. 2005, 73:94-105.
46. Brazil D.P., Yang Z.Z., Hemmings B.A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 2004, 29:233-242.
47. Boer A.K., Drayer A.L., Vellenga E. cAMP/PKA-mediated regulation of erythropoiesis. Leuk. Lymphoma 2003, 44:1893-1901.
48. Dobkin-Bekman M., Naidich M., Pawson A.J., Millar R.P., Seger R., Naor Z. Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent. Mol. Cell. Endocrinol. 2006, 252:184-190.
49. Bhanu N.V., Lee Y.T., Oneal P.A., Gantt N.M., Aerbajinai W., Noel P., Thomas C.J., Miller J.L. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. Biochim. Biophys. Acta 2008, 1782:504-510.
50. Yang J., Naik S.G., Ortillo D.O., Garcia-Serres R., Li M., Broderick W.E., Huynh B.H., Broderick J.B. The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state. Biochemistry 2009, 48:9234-9241.
51. El-Beshlawy A., Hamdy M., El Ghamrawy M. Fetal globin induction in beta-thalassemia. Hemoglobin 2009, 33(Suppl 1):S197-S203.
52. Galanello R., Origa R. Beta-thalassemia. Orphanet J. Rare Dis. 2010, 5:11.
53. Prus E., Fibach E. Effect of iron chelators on labile iron and oxidative status of thalassaemic erythroid cells. Acta Haematol. 2009, 123:14-20.