Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1782, Issue 9, 2008, Pages 504-510

  Bhanu, Natarajan V ^a   Lee, Y Terry ^a   Oneal, Patricia A ^a   Gantt, Nicole M ^a   Aerbajinai, Wulin ^a   Noel, Pierre ^b   Thomas, Craig J ^b   Miller, Jeffery L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Adenosine derivative; Cytokine; HbF inhibition; Hemoglobinopathy; Human erythropoiesis; SQ22536

Indexed keywords

2',3' DIDEOXYADENOSINE; 5' DEOXYADENOSINE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR; CYCLIC AMP; HEMOGLOBIN F; RIBOSE;

ARTICLE; BLOOD; CELL CULTURE; CELL GROWTH; DOWN REGULATION; DRUG MECHANISM; ERYTHROBLAST; FETUS BLOOD; HUMAN; HUMAN CELL; LIGAND BINDING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSCRIPTION INITIATION;

ADENINE; ADENOSINE; ADULT; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIC AMP; DEOXYADENOSINES; DIDEOXYADENOSINE; ERYTHROBLASTS; ERYTHROPOIETIN; FETAL HEMOGLOBIN; FORSKOLIN; GENE EXPRESSION REGULATION; GENE SILENCING; GLOBINS; HUMANS; KINETICS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 49349088682     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2008.05.004     Document Type: Article

References (23)

1. DeSimone J., Biel S.I., and Heller P. Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia. Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 2937-2940
2. Boyer S.H., Dover G.J., Serjeant G.R., Smith K.D., Antonarakis S.E., Embury S.H., et al. Production of F cells in sickle cell anemia: regulation by a genetic locus or loci separate from the beta-globin gene cluster. Blood 64 (1984) 1053-1058
3. Charache S. Fetal hemoglobin sickling and sickle cell disease. Adv. Pediatr. 37 (1990) 1-31
4. Rochette J., Craig J.E., and Thein S.L. Fetal hemoglobin levels in adults. Blood Rev. 8 (1994) 213-224
5. Steinberg M.H. Determinants of fetal hemoglobin response to hydroxyurea. Semin. Hematol. 34 (1997) 8-14
6. Saunthararajah Y., and DeSimone J. Clinical studies with fetal hemoglobin-enhancing agents in sickle cell disease. Semin. Hematol. 41 (2004) 11-16
7. Croizat H., and Nagel R.L. Circulating cytokines response and the level of erythropoiesis in sickle cell anemia. Am. J. Hematol. 60 (1999) 105-115
8. Miller J.L. Signaled expression of fetal hemoglobin during development. Transfusion 45 (2005) 1229-1232
9. Bhanu N.V., Trice T.A., Lee Y.T., and Miller J.L. A signaling mechanism for growth-related expression of fetal hemoglobin. Blood 103 (2004) 1929-1933
10. Pace B.S., Qian X.H., Sangerman J., Ofori-Acquah S.F., Baliga B.S., Han J., and Critz S.D. p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Exp. Hematol. 31 (2003) 1089-1096
11. Inoue A., Kuroyanagi Y., Terui K., Moi P., and Ikuta T. Negative regulation of gamma-globin gene expression by cyclic AMP-dependent pathway in erythroid cells. Exp. Hematol. 32 (2004) 244-253
12. Bhanu N.V., Trice T.A., Lee Y.T., Gantt N.M., Oneal P.A., Schwartz J.D., et al. A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells. Blood 105 (2005) 387-33
13. Bhanu N.V., Aerbajinai W., Gantt N.M., Jackson E.K., Goh S.H., Lee Y.T., et al. Cl-IB-MECA inhibits human erythropoiesis. Br. J. Haematol. 137 (2007) 233-236
14. Keefer J.R., Schneidereith T.A., Mays A., Purvs S.H., Dover G.J., and Smith K.D. Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells. Exp. Hematol. 34 (2006) 1150-1160
15. Bard H., and Prosmanne J. Relative rates of fetal hemoglobin and adult hemoglobin synthesis in cord blood of infants of insulin-dependent diabetic mothers. Pediatrics 75 (1985) 1143-1147
16. Wojda U., Leigh K.R., Njoroge J.M., Jackson K.A., Natarajan B., Stitely M., and Miller J.L. Fetal hemoglobin modulation during human erythropoiesis: stem cell factor has "late" effects related to the expression pattern of CD117. Blood 101 (2003) 492-497
17. Johnson R.A., Desaubry L., Bianchi G., Shoshani I., Lyons Jr. E., Taussig R., et al. Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates. J. Biol. Chem. 272 (1997) 8962-8966
18. Schulte G., and Fredholm B.B. Diverse inhibitors of intracellular signaling act as adenosine receptor antagonists. Cell Signal. 14 (2002) 109-113
19. Spehr M., Schwane K., Riffell J.A., Barbour J., Zimmer R.K., Neuhaus E.M., and Hatt H. Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J. Biol. Chem. 279 (2004) 40194-40203
20. Kashima Y., Miki T., Shibasaki T., Ozaki N., Miyazaki M., Yano H., and Seino S. Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 7 (2001) 46046-46053
21. Bailey L., Kuroyanagi Y., Franco-Penteado C.F., Conran N., Costa F.F., Ausenda S., Cappellini M.D., and Ikuta T. Expression of the gamma-globin gene is sustained by the cAMP-dependent pathway in beta-thalassaemia. Br. J. Haematol. 138 (2007) 382-395
22. Oneal P.A., Gantt N.M., Schwartz J.D., Bhanu N.V., Lee Y.T., Moroney J.W., et al. Fetal hemoglobin silencing in humans. Blood 108 (2006) 2081-2086
23. Bard H. Hypoxemia and increased fetal hemoglobin synthesis during the perinatal period. Semin. Perinatol. 16 (1992) 191-195