Clinical and hematologic aspects of hemoglobin E β-thalassemia

Current Opinion in Hematology

Volumn 7, Issue 2, 2000, Pages 106-112

  Fucharoen, Suthat ^a   Winichagoon, Pranee ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A; HEMOGLOBIN E; HEMOGLOBIN F;

ADOLESCENT; ADULT; ARTICLE; ATHEROSCLEROSIS; BETA THALASSEMIA; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; CHILD; CLINICAL FEATURE; DISEASE SEVERITY; ERYTHROPOIESIS; GENE MUTATION; GENOTYPE; HUMAN; HYPERTENSION; INFANT; IRON OVERLOAD; MAJOR CLINICAL STUDY; NEWBORN; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; THALASSEMIA; THROMBOEMBOLISM;

ASIA, SOUTHEASTERN; BETA-THALASSEMIA; GENOTYPE; HEMOGLOBIN E; HUMANS; PHENOTYPE; PRENATAL DIAGNOSIS;

EID: 0033953189     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200003000-00006     Document Type: Article

References (55)

1. 1 Fucharoen S, Winichagoon P, Pootrakul P, Wasi P: Determination for different severity of anemia in thalassemia: concordance and discordance among sib pairs. Am J Med Genet 1984, 19:39-44.
2. 2 Wasi P, Pootrakul P, Fucharoen S, Winichagoon P, Wilairat P, Promboon A: Thalassemia in Southeast Asia: determination of different degrees of severity of anemia in thalassemia. Ann N Y Acad Sci 1985, 445:119-126.
3. 3 Fucharoen S, Winichagoon P, Pootrakul P, Piankijagum A, Wasi P: Variable severity of Southeast Asian β̊-thalassemia/Hb E disease. Birth Defects 1988, 23:241-248.
4. 4 Rees DC, Styles L, Vichinsky EP, Clegg JB, Weatherall DJ: The hemoglobin E syndromes. Ann N Y Acad Sci 1998, 850:334-343.
5. 5 Fucharoen S, Ketvichit P, Pootrakul P, Siritanaratkul N, Piankijagum A, Wasi P: The clinical manifestation of β-thalassemia/Hb E disease. J Pediatr Hematol Oncol 1999, in press.
6. 6 Beguin Y, Clemons GK, Pootrakul P, Fillet G: Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood 1993, 81:1067-1076.
7. 7 Issaragrisil S, Piankijagum A, Wasi P: Spinal cord compression in thalassemia: report of 12 cases and recommendation for treatment. Arch Intern Med 1981, 141:1033-1036.
8. 8 Fucharoen S, Suthipongchai S, Poungvarin N, Ladpli S, Sonakul D, Wasi P: Intracranial extramedullary hematopoiesis inducing epilepsy in a patient with β-thalassemia-hemoglobin E. Arch Intern Med 1985, 145:739-742.
9. 9 Pootrakul P, Hungsprenges S, Fucharoen S, Baylink D, Thompson E, English E, et al.: Relation between erythropoiesis and bone metabolism in thalassemia. N Engl J Med 1981, 304:1470-1473.
10. 10 Christensen RA, Pootrakul P, Burrnell JM, Teuner EJ, Finch CA, Baylink DJ: Patients with thalassemia develop osteoporosis, osteomalacia, and hypoparathyroidism, all of which are corrected by transfusion. Birth Defects 1988, 23:409-416.
11. 11 Brittenham G, Pootrakul P, Finch CA, Yansukon P, Kitcharoen K, Fucharoen S, et al.: Iron overload in Hb E-β-thalassemia: magnetic measurement of hepatic iron stores [abstract]. Blood 1986, 68:72.
12. 12 Pootrakul P, Huebers HA, Finch CA, Pippard MJ, Cazzola M: Iron metabolism in thalassemia. Birth Defects 1988, 23:3-8.
13. 13 Pootrakul P, Kitcharoen K, Yansukon P, Wasi P, Fucharoen S, Charoenlarp P, et al.: The effect of erythroid hyperplasia on iron balance. Blood 1988, 71:1124-1129.
14. 14 Thakerngpol K, Sonakul D, Fucharoen S, Vathanopas V, Stinimankarn T: Histochemical study of liver tissue from thalassemic patients. Birth Defects 1988, 23:193-198.
15. 15 Thakerngpol K, Sonakul D, Fucharoen S, Boonyaphiphat P, Vathanopas V, Sahaphong S, Stitnimankarn T: Electron microscopic study of liver tissue from 30 thalassemic patients. Birth Defects 1988, 23:199-206.
16. 16 Vannasaeng S, Fucharoen S, Nitiyanant W, Vichayanrat A, Pootrakul P, Piraphatdist T: Impaired glucose counter regulation after insulin induced hypoglycemia in thalassemia patients. J Med Assoc Thailand 1987, 70:631-637.
17. 17 Suthipark K, Ong-ajyooth S, Shumnumsirivath D, Likidlilid A, Fucharoen S, Siddhikol C, et al.: Oxidative stress and antioxidants in β-thalassemia/hemoglobin E. Birth Defects 1988, 23:199-205.
18. 18 Livrea MA, Tesoriere L, Maggio A, D'Arpa D, Pintaudi AM, Pedone E: Oxidative modification of low-density lipoprotein and atherogenetic risk in β-thalassemia. Blood 1998, 92:3936-3942.
19. 19 Sonakul D, Pacharee P, Wasi P, Fucharoen S: Cardiac pathology in 47 patients with beta thalassemia/hemoglobin E. Southeast Asian J Trop Med Public Health 1984, 15:554-563.
20. 20 Economou-Petersen E, Aessopos A, Kladi A, Flevari P, Karabatsos F, Fragodimitri C, et al.: Apolipoprotein E ε4 allele as a genetic risk factor for left ventricular failure in homozygous β-thalassemia. Blood 1998, 92:3455-3459.
21. 21 Jootar P, Fucharoen S: Cardiac involvement in beta-thalassemia/hemoglobin E disease: clinical and hemodynamic findings. Southeast Asian J Trop Med Public Health 1990, 21:269-273.
22. 22 Fucharoen S, Piankijagum A, Wasi P: Deaths in β-thalassemia/Hb E patients secondary to infections. Birth Defects 1988, 23:495-500.
23. 23 Issaragrisil S, Wanachiwanawin W, Bhuripanyo K, Benjasuratwong Y, Piankijagum A, Wasi P: Infection in thalassemia: a retrospective study of 1,018 patients with β-thalassemia/Hb E disease. Birth Defects 1988, 23:505-511.
24. 24 Aswapokee N, Aswapokee P, Fucharoen S, Wasi P: A study of infective episodes in patients with β-thalassemia/Hb E disease in Thailand. Birth Defects 1988, 23:513-520.
25. 25 Aswapokee P, Aswapokee N, Fucharoen S, Sukroongreung S, Wasi P: Severe infection in thalassemia: a prospective study. Birth Defects 1988, 23:521-526.
26. 26 Wasi C, Kuntang R, Louisirirotchanakul S, Siritantikorn S, Fucharoen S, Aswapokee P: Viral infections in β-thalassemia/hemoglobin E patients. Birth Defects 1988, 23:547-555.
27. 27 Wanachiwanawin W, Thianprasit M, Fucharoen S, Chaiprasert A, Sudasna N, Ayuthaya N, et al.: Fatal arteritis due to pythium insidiosum infection in patients with thalassemia. Trans R Soc Trop Med Hyg 1993, 87:296-298.
28. 28 Wanachiwanawin W, Siripanyaphinyo U, Fucharoen S, Wasi P, Mawas F, Wiener E, Wickramasinghe SN: Activation of monocytes for the immune clearance of red cells in β̊-thalassemia/HbE. Br J Haematol 1993, 85:773-777.
29. 29 Wanachiwanawin W, Chucharoen J, Pattanapanyasat K, Fucharoen S, Webster HK: Lymphocytes in β-thalassemia/Hb E: subpopulations and mitogen responses. Eur J Haematol 1996, 55:153-157.
30. 30 Wanachiwanawin W, Wiener E, Siripanyaphinyo U, Chinprasertsuk S, Mawas F, Fucharoen S, et al.: Serum levels of tumor necrosis factor-α, interleukin-1, and interferon-in β̊-thalassemia/Hb E and their clinical significance. J Interferon Cytokine Res 1999, 19:1050-1011.
31. 31 Malasit P, Mahasorn W, Mongkolsapaya J, Singhathong B, Fucharoen S, Wasi P, Bhakdi S: Presence of immunoglobulins, C3 and cytolytic C5b-9 complement components on the surface of erythrocytes from patients with β-thalassaemia/Hb E disease. Br J Haematol 1997, 96:507-513.
32. 32 Wasi P, Na-Nakorn S, Pootrakul P, Sonakul D, Piankijagum A, Pacharee P: A syndrome of hypertension, convulsion and cerebral haemorrhage in thalassaemic patients after multiple blood-transfusions. Lancet 1978, ii:602-604.
33. 33 Thirawarapan S, Snongchart N, Fucharoen S, Tanphaichitr VS, Dhorranintra B: Study of mechanisms of post-transfusion hypertension in thalassaemic patients. Southeast Asian J Trop Med Public Health 1989, 20:471-478.
34. 34 Sonakul D, Fucharoen S: Brain pathology in 6 fatal cases of post-transfusion hypertension, convulsion and cerebral hemorrhage syndrome. Southeast Asian J Trop Med Public Health 1992, 23(Suppl 2):116-119.
35. 35 Fucharoen S, Youngchaiyud P, Wasi P: Hypoxaemia and the effect of aspirin in thalassaemia. Southeast Asian J Trop Med Public Health 1981, 12:90-93.
36. 36 Winichagoon P, Fucharoen S, Wasi P: Increased circulating platelet aggregates in thalassaemia. Southeast Asian J Trop Med Public Health 1981, 12:556-560.
37. 37 Sonakul D, Pacharee P, Laohapand T, Fucharoen S, Wasi P: Pulmonary artery obstruction in thalassaemia. Southeast Asian J Trop Med Public Health 1980, 11:516-523.
38. 38 Sonakul D, Fucharoen S: Pulmonary thromboembolism in thalassemic patients. Southeast Asian J Trap Med Public Health 1992, 23(Suppl 2):25-28.
39. 39 Sonakul D, Suwanagool P, Sirivaidyapong P, Fucharoen S: Distribution of pulmonary thromboembolic lesions in thalassemic patients. Birth Defects 1988, 23:375-384.
40. 40 Opartkiattikul N, Funahara Y, Fucharoen S, Thalalak P: Increase in spontaneous platelet aggregation in β-thalassemia/hemoglobin E disease: a consequence of splenectomy. Southeast Asian J Trop Med Public Health 1992, 23(Suppl 2):36-41.
41. 41 Opartkiattikul N, Funahara Y, Hijikata-Okunomiya A, Yamaguchi A, Fucharoen S, Talalak P: Detection of PF3 availability in whole blood from volunteers and β-thalassemia/HbE patients: a promising method for prediction of thrombolytic tendency. Southeast Asian J Trop Med Public Health 1992, 23(Suppl 2):52-59.
42. 42 Shirahata A, Funahara Y, Opartkiattikul N, Fucharoen S, Laosombat V, Yamada K: Protein C and protein S deficiency in thalassemic patients. Southeast Asian J Trop Med Public Health 1992, 23(Suppl 2):65-73.
43. 43 Butthep P, Bunyaratvej A, Kitaguchi H, Funahara Y, Fucharoen S: Interaction between endothelial cells and thalassemic red cells in vitro. Southeast Asian J Trop Med Public Health 1992, 23(Suppl 2):101-104.
44. 44 Butthep P, Bunyaratvej A, Funahara Y, Kitaguchi H, Fucharoen S, Sato S, Bhamarapravati N: Alterations in vascular endothelial cell-related plasma proteins in thalassaemic patients and their correlation with clinical symptoms. Thromb Haemost 1995, 74:1045-1049.
45. 45 Ho PJ, Hall GW, Luo LY, Weatherall DJ, Thein SL: Beta-thalassaemia intermedia: is it possible consistently to predict phenotype from genotype? Br J Haematol 1998, 100:70-78. This article demonstrates the complex genotype-phenotype interaction in β-thalassemia disorders.
46. 46 Winichagoon P, Thonglairoam V, Fucharoen S, Wilairat P, Fukumaki Y, Wasi P: Severity differences in β-thalassemia/haemoglobin E syndromes: implication of genetic factor. Br J Haematol 1993, 83:633-639.
47. 47 Winichagoon P, Fucharoen S, Ping Chen, Wasi P: Genetic factors affecting clinical severity in β-thalassemia syndromes. J Pediatr Hematol Oncol 1999, in press. This article describes the effect of multiple genetic factors that may modify the severity of hemoglobin E β-thalassemia. The authors had characterized both α-and β-globin genes in the patients with different seventy.
48. 48 Winichagoon P, Fucharoen S, Weatherall DJ, Wasi P: Concomitant inheritance of α-thalassemia in β̊-thalassemia/Hb E disease. Am J Hematol 1985, 20:217-222.
49. 49 Fucharoen S, Winichagoon P, Wisedpanichkij R, Sae-Ngow B, Sriphanich R, Oncoung W, et al.: Prenatal and postnatal diagnoses of thalassemias and hemoglobinopathies by HPLC. Clin Chem 1998, 44:740-748.
50. 50 Fucharoen S, Winichagoon V, Prayoonwiwat W, Pootrakul P, Piankijagum A, Wasi P: Clinical and hematologic manifestations of AE Bart's disease. Birth Defects 1988, 23:327-332.
51. 51 Thonglairuam V, Winichagoon P, Fucharoen S, Wasi P: The molecular basis of AE-Bart's disease. Hemoglobin 1989, 13:117-124.
52. 52 Fucharoen S, Winichagoon P, Thonglairuam V, Wasi P: EF Bart's disease: interaction of the abnormal α-and β-globin genes. Eur J Haematol 1988, 40:75-78.
53. 53 Pootrakul S, Muang-sup V, Fucharoen S, Wasi P: Cord blood study on β-thalassemia and hemoglobin E. Am J Med Genet 1988, 29:49-57.
54. 54 Winichagoon P, Saechan V, Sripanich R, Nopparatana C, Kanokpongsakdi S, Maggio A, Fucharoen S: Prenatal diagnosis of β-thalassaemia by reverse dot-blot hybridization. Prenat Diagn 1999, 19:428-435.
55. 55 Fucharoen S, Siritanaratkul N, Winichagoon P, Chowthaworn J, Siriboon W, Muangsup W, et al.: Hydroxyurea increases hemoglobin F levels and improves the effectiveness of erythropoiesis in β-thalassemia/hemoglobin E disease. Blood 1996, 87:887-892.