Galectin-3 and the skin

Journal of Dermatological Science

Volumn 64, Issue 2, 2011, Pages 85-91

  Larsen, Larissa ^a   Chen, Huan Yuan ^a,b   Saegusa, Jun ^c   Liu, Fu Tong ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c KOBE UNIVERSITY   (Japan)

Author keywords

Galectins; Lectins; Skin cancer; Skin inflammation

Indexed keywords

GALECTIN 3; IMMUNOGLOBULIN E; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B;

ANTIGEN PRESENTING CELL; APOPTOSIS; ATOPIC DERMATITIS; BASAL CELL CARCINOMA; CELL INTERACTION; CONTACT DERMATITIS; ENZYME ACTIVATION; HUMAN; IMMUNOREACTIVITY; INFLAMMATION; KERATINOCYTE; MELANOMA; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN PROTEIN INTERACTION; PSORIASIS; REVIEW; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN DISEASE; SKIN FIBROBLAST; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE ACTIVATION; TUMOR GROWTH;

ANIMALS; ANTIGEN-PRESENTING CELLS; DERMATITIS, ATOPIC; DERMATITIS, CONTACT; GALECTIN 3; HUMANS; KERATINOCYTES; MELANOMA; PSORIASIS; SKIN DISEASES; SKIN NEOPLASMS;

EID: 80053385529     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.07.008     Document Type: Review

References (62)

1. Cummings R.D., Liu F.T. Galectins. Essentials of glycobiology 2009, Cold Spring Harbor Laboratory Press, [Chapter 33]. 2nd edition.
2. Hirabayashi J., Hashidate T., Arata Y., Nishi N., Nakamura T., Hirashima M., Urashima T., Oka T., Futai M., Muller W.E., Yagi F., Kasai K. Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochim Biophys Acta 2002, 1572:232-254.
3. Swaminathan G.J., Leonidas D.D., Savage M.P., Ackerman S.J., Acharya K.R. Selective recognition of mannose by the human eosinophil charcot-leyden crystal protein (galectin-10): a crystallographic study at 1.8A resolution. Biochemistry 1999, 38:15406.
4. Ahmad N., Gabius H.J., Andre S., Kaltner H., Sabesan S., Roy R., Liu B., Macaluso F., Brewer C.F. Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes. J Biol Chem 2004, 279:10841-10847.
5. Sacchettini J.C., Baum L.G., Brewer C.F. Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction. Biochemistry 2001, 40:3009-3015.
6. Moutsatsos I.K., Wade M., Schindler M., Wang J.L. Endogenous lectins from cultured cells: nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts. Proc Natl Acad Sci USA 1987, 84:6452-6456.
7. Cowles E.A., Agrwal N., Anderson R.L., Wang J.L. Carbohydrate-binding protein 35. Isoelectric points of the polypeptide and a phosphorylated derivative. J Biol Chem 1990, 265:17706-17712.
8. Yang R.Y., Rabinovich G.A., Liu F.T. Galectins: structure, function and therapeutic potential. Expert Rev Mol Med 2008, 10:e17.
9. Dennis J.W., Nabi I.R., Demetriou M. Metabolism, cell surface organization, and disease. Cell 2009, 139:1229-1241.
10. Liu F.T., Patterson R.J., Wang J.L. Intracellular functions of galectins. Biochim Biophys Acta 2002, 1572:263-273.
11. Haudek K.C., Spronk K.J., Voss P.G., Patterson R.J., Wang J.L., Arnoys E.J. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta 2010, 1800:181-189.
12. Nakahara S., Raz A. Regulation of cancer-related gene expression by galectin-3 and the molecular mechanism of its nuclear import pathway. Cancer Metast Rev 2007, 26:605-610.
13. Konstantinov K.N., Shames B., Izuno G., Liu F.T. Expression of epsilon BP, a beta-galactoside-binding soluble lectin, in normal and neoplastic epidermis. Exp Dermatol 1994, 3:9-16.
14. Plzak J., Smetana K., Hrdlickova E., Kodet R., Holikova Z., Liu F.T., Dvorankova B., Kaltner H., Betka J., Gabius H.J. Expression of galectin-3-reactive ligands in squamous cancer and normal epithelial cells as a marker of differentiation. Int J Oncol 2001, 19:59-64.
15. Sarafian V., Jans R., Poumay Y. Expression of lysosome-associated membrane protein 1 (Lamp-1) and galectins in human keratinocytes is regulated by differentiation. Arch Dermatol Res 2006, 298:73-81.
16. Saegusa J., Hsu D.K., Liu W., Kuwabara I., Kuwabara Y., Yu L., Liu F.T. Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation. J Invest Dermatol 2008, 128:2403-2411.
17. Kariya Y., Kawamura C., Tabei T., Gu J. Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility. J Biol Chem 2010, 285:3330-3340.
18. Hamann K.K., Cowles E.A., Wang J.L., Anderson R.L. Expression of carbohydrate binding protein 35 in human fibroblasts: variations in the levels of mRNA, protein, and isoelectric species as a function of replicative competence. Exp Cell Res 1991, 196:82-91.
19. Lippert E., Falk W., Bataille F., Kaehne T., Naumann M., Goeke M., Herfarth H., Schoelmerich J., Rogler G. Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor. Gut 2007, 56:43-51.
20. Wollenberg A., de la Salle H., Hanau D., Liu F.T., Bieber T. Human keratinocytes release the endogenous beta-galactoside-binding soluble lectin immunoglobulin E (IgE-binding protein) which binds to Langerhans cells where it modulates their binding capacity for IgE glycoforms. J Exp Med 1993, 178:777-785.
21. Bax M., Garcia-Vallejo J.J., Jang-Lee J., North S.J., Gilmartin T.J., Hernandez G., Crocker P.R., Leffler H., Head S.R., Haslam S.M., Dell A., van Kooyk Y. Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol 2007, 179:8216-8224.
22. Bernardes E.S., Silva N.M., Ruas L.P., Mineo J.R., Loyola A.M., Hsu D.K., Liu F.T., Chammas R., Roque-Barreira M.C. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity. Am J Pathol 2006, 168:1910-1920.
23. Breuilh L., Vanhoutte F., Fontaine J., van Stijn C.M., Tillie-Leblond I., Capron M., Faveeuw C., Jouault T., van Die I., Gosset P., Trottein F. Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells. Infect Immun 2007, 75:5148-5157.
24. Hsu D.K., Chernyavsky A.I., Chen H.Y., Yu L., Grando S.A., Liu F.T. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol 2009, 129:573-583.
25. Sano H., Hsu D.K., Apgar J.R., Yu L., Sharma B.B., Kuwabara I., Izui S., Liu F.T. Critical role of galectin-3 in phagocytosis by macrophages. J Clin Invest 2003, 112:389-397.
26. Karlsson A., Christenson K., Matlak M., Bjorstad A., Brown K.L., Telemo E., Salomonsson E., Leffler H., Bylund J. Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology 2009, 19:16-20.
27. Liu F.T., Rabinovich G.A. Galectins: regulators of acute and chronic inflammation. Ann NY Acad Sci 2010, 1183:158-182.
28. Hsu D.K., Yang R.Y., Liu F.T. Galectins in apoptosis. Methods Enzymol 2006, 417:256-273.
29. Demetriou M., Granovsky M., Quaggin S., Dennis J.W. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 2001, 409:733-739.
30. Chen H.Y., Fermin A., Vardhana S., Weng I.C., Lo K.F., Chang E.Y., Maverakis E., Yang R.Y., Hsu D.K., Dustin M.L., Liu F.T. Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci USA 2009, 106:14496-14501.
31. Sano H., Hsu D.K., Yu L., Apgar J.R., Kuwabara I., Yamanaka T., Hirashima M., Liu F.T. Human galectin-3 is a novel chemoattractant for monocytes and macrophages. J Immunol 2000, 165:2156-2164.
32. MacKinnon A.C., Farnworth S.L., Hodkinson P.S., Henderson N.C., Atkinson K.M., Leffler H., Nilsson U.J., Haslett C., Forbes S.J., Sethi T. Regulation of alternative macrophage activation by galectin-3. J Immunol 2008, 180:2650-2658.
33. Chen H.Y., Sharma B.B., Yu L., Zuberi R., Weng I.C., Kawakami Y., Kawakami T., Hsu D.K., Liu F.T. Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression. J Immunol 2006, 177:4991-4997.
34. Ong P.Y., Leung D.Y. Immune dysregulation in atopic dermatitis. Curr Allergy Asthma Rep 2006, 6:384-389.
35. Kimata H. Enhancement of IgE production in B cells by neutrophils via galectin-3 in IgE-associated atopic eczema/dermatitis syndrome. Int Arch Allergy Immunol 2002, 128:168-170.
36. Saegusa J., Hsu D.K., Chen H.Y., Yu L., Fermin A., Fung M.A., Liu F.T. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am J Pathol 2009, 174:922-931.
37. Gazel A., Rosdy M., Tornier C., De Fraissinette Ade B., Blumenberg M. Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes. J Cell Physiol 2008, 217:686-692.
38. Lacina L., Plzakova Z., Smetana K., Stork J., Kaltner H., Andre S. Glycophenotype of psoriatic skin. Folia Biol (Praha) 2006, 52:10-15.
39. Liu F.T., Rabinovich G.A. Galectins as modulators of tumour progression. Nat Rev Cancer 2005, 5:29-41.
40. Elad-Sfadia G., Haklai R., Balan E., Kloog Y. Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J Biol Chem 2004, 279:34922-34930.
41. Cecchinelli B., Lavra L., Rinaldo C., Iacovelli S., Gurtner A., Gasbarri A., Ulivieri A., Del Prete F., Trovato M., Piaggio G., Bartolazzi A., Soddu S., Sciacchitano S. Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis. Mol Cell Biol 2006, 26:4746-4757.
42. Shimura T., Takenaka Y., Fukumori T., Tsutsumi S., Okada K., Hogan V., Kikuchi A., Kuwano H., Raz A. Implication of galectin-3 in Wnt signaling. Cancer Res 2005, 65:3535-3537.
43. Hsu D.K., Chen H.Y., Liu F.T. Galectin-3 regulates T-cell functions. Immunol Rev 2009, 230:114-127.
44. Lotan R., Raz A. Endogenous lectins as mediators of tumor cell adhesion. J Cell Biochem 1988, 37:107-117.
45. Bresalier R.S., Mazurek N., Sternberg L.R., Byrd J.C., Yunker C.K., Nangia-Makker P., Raz A. Metastasis of human colon cancer is altered by modifying expression of the beta-galactoside-binding protein galectin 3. Gastroenterology 1998, 115:287-296.
46. Kapucuoglu N., Basak P.Y., Bircan S., Sert S., Akkaya V.B. Immunohistochemical galectin-3 expression in non-melanoma skin cancers. Pathol Res Pract 2009, 205:97-103.
47. Mollenhauer J., Deichmann M., Helmke B., Muller H., Kollender G., Holmskov U., Ligtenberg T., Krebs I., Wiemann S., Bantel-Schaal U., Madsen J., Bikker F., Klauck S.M., Otto H.F., Moldenhauer G., Poustka A. Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer. Int J Cancer 2003, 105:149-157.
48. Prieto V.G., Mourad-Zeidan A.A., Melnikova V., Johnson M.M., Lopez A., Diwan A.H., Lazar A.J., Shen S.S., Zhang P.S., Reed J.A., Gershenwald J.E., Raz A., Bar-Eli M. Galectin-3 expression is associated with tumor progression and pattern of sun exposure in melanoma. Clin Cancer Res 2006, 12:6709-6715.
49. Mourad-Zeidan A.A., Melnikova V.O., Wang H., Raz A., Bar-Eli M. Expression profiling of galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry. Am J Pathol 2008, 173:1839-1852.
50. Abdou A.G., Hammam M.A., Farargy S.E., Farag A.G., El Shafey E.N., Farouk S., Elnaidany N.F. Diagnostic and prognostic role of galectin 3 expression in cutaneous melanoma. Am J Dermatopathol 2010, 32:809-814.
51. Vereecken P., Debray C., Petein M., Awada A., Lalmand M.C., Laporte M., Van Den Heule B., Verhest A., Pochet R., Heenen M. Expression of galectin-3 in primary and metastatic melanoma: immunohistochemical studies on human lesions and nude mice xenograft tumors. Arch Dermatol Res 2005, 296:353-358.
52. Iurisci I., Tinari N., Natoli C., Angelucci D., Cianchetti E., Iacobelli S. Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res 2000, 6:1389-1393.
53. Vereecken P., Zouaoui Boudjeltia K., Debray C., Awada A., Legssyer I., Sales F., Petein M., Vanhaeverbeek M., Ghanem G., Heenen M. High serum galectin-3 in advanced melanoma: preliminary results. Clin Exp Dermatol 2006, 31:105-109.
54. Forgber M., Trefzer U., Sterry W., Walden P. Proteome serological determination of tumor-associated antigens in melanoma. PLoS One 2009, 4:e5199.
55. Raz A., Meromsky L., Zvibel I., Lotan R. Transformation-related changes in the expression of endogenous cell lectins. Int J Cancer 1987, 39:353-360.
56. Lapis K., Timar J. Role of elastin-matrix interactions in tumor progression. Semin Cancer Biol 2002, 12:209-217.
57. Pocza P., Suli-Vargha H., Darvas Z., Falus A. Locally generated VGVAPG and VAPG elastin-derived peptides amplify melanoma invasion via the galectin-3 receptor. Int J Cancer 2008, 122:1972-1980.
58. Inohara H., Raz A. Functional evidence that cell surface galectin-3 mediates homotypic cell adhesion. Cancer Res 1995, 55:3267-3271.
59. Inohara H., Akahani S., Koths K., Raz A. Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Res 1996, 56:4530-4534.
60. Ochieng J., Leite-Browning M.L., Warfield P. Regulation of cellular adhesion to extracellular matrix proteins by galectin-3. Biochem Biophys Res Commun 1998, 246:788-791.
61. van den Brule F.A., Buicu C., Sobel M.E., Liu F.T., Castronovo V. Galectin-3, a laminin binding protein, fails to modulate adhesion of human melanoma cells to laminin. Neoplasma 1995, 42:215-219.
62. Mollenhauer J., Helmke B., Muller H., Kollender G., Krebs I., Wiemann S., Holmskov U., Madsen J., Otto H.F., Poustka A. An integrative model on the role of DMBT1 in epithelial cancer. Cancer Detect Prev 2002, 26:266-274.