Sedative load of medications prescribed for older people with dementia in care homes

BMC Geriatrics

Volumn 11, Issue , 2011, Pages

  Parsons, Carole ^a   Haydock, Jane ^a   Mathie, Elspeth ^b   Baron, Natasha ^c   MacHen, Ina ^b   Stevenson, Elizabeth ^b   Amador, Sarah ^b   Goodman, Claire ^b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYPNOTIC SEDATIVE AGENT; PRESCRIPTION DRUG;

AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; DEMENTIA; FEMALE; HOME FOR THE AGED; HUMAN; MALE; MULTICENTER STUDY; NURSING HOME; POLYPHARMACY; PROSPECTIVE STUDY; PSYCHOLOGICAL ASPECT;

AGED; AGED, 80 AND OVER; DEMENTIA; FEMALE; HOMES FOR THE AGED; HUMANS; HYPNOTICS AND SEDATIVES; MALE; NURSING HOMES; POLYPHARMACY; PRESCRIPTION DRUGS; PROSPECTIVE STUDIES;

EID: 80053369753     PISSN: None     EISSN: 14712318     Source Type: Journal    
DOI: 10.1186/1471-2318-11-56     Document Type: Article

References (63)

1. Care homes' use of medicines study: prevalence, causes and potential harm of medication errors in care homes for older people. Barber ND, Alldred DP, Raynor DK, Dickinson R, Garfield S, Jesson B, Lim R, Savage I, Standage C, Buckle P, Qual Saf Health Care 2009 18 341 346 10.1136/qshc.2009.034231 19812095
2. Good Practice outside the care homes. Goodman C, Davies SL, Mental Health and Care Homes Oxford, Oxford University Press, Dening T, Milne A, 2011 297 312
3. Administrative initiatives for reducing inappropriate prescribing of psychotropic drugs in nursing homes: how successful have they been? Hughes CM, Lapane KL, Drugs Aging 2005 22 339 351 10.2165/00002512-200522040-00006 15839722 (Pubitemid 40656022)
4. Nursing time devoted to medication administration in long-term care: clinical, safety, and resource implications. Thomson MS, Gruneir A, Lee M, Baril J, Field TS, Gurwitz JH, Rochon PA, J Am Geriatr Soc 2009 57 266 272 10.1111/j.1532-5415.2008.02101.x 19170782
5. Polypharmacy in elderly patients. Hajjar ER, Cafiero AC, Hanlon JT, Am J Geriatr Pharmacother 2007 5 345 351 10.1016/j.amjopharm.2007.12.002 18179993
6. Clinical medication review by a pharmacist of elderly people living in care homes: pharmacist interventions. Alldred DP, Zermansky AG, Petty DR, Raynor DK, Freemantle N, Eastaugh J, Bowie P, Int J Pharm Pract 2007 15 93 99 10.1211/ijpp.15.2.0003 (Pubitemid 46847598)
7. Does organisational culture influence prescribing in care homes for older people? A new direction for research. Hughes CM, Lapane K, Watson MC, Davies HTO, Drugs Aging 2007 24 81 93 10.2165/00002512-200724020-00001 17313197 (Pubitemid 46327568)
8. Pharmacists Interventions for Optimization of Medication Use in Nursing Homes: A Systematic Review. Verrue CLR, Petrovic M, Mehuys E, Remon JP, Vander Stichele R, Drugs Aging 2009 26 37 49 10.2165/0002512-200926010-00003 19102513
9. Adverse drug events in cognitively impaired elderly patients. Ganjavi H, Herrmann N, Rochon PA, Sharma P, Lee M, Cassel D, Freedman M, Black SE, Lanctôt KL, Dement Geriatr Cogn Disord 2007 23 395 400 10.1159/000101454 17396031 (Pubitemid 46897176)
10. Explicit, evidence-based criteria to assess the quality of prescribing to elderly nursing home residents. Oborne CA, Hooper R, Swift CG, Jackson SHD, Age Ageing 2003 32 102 108 10.1093/ageing/32.1.102 12540356 (Pubitemid 36193246)
11. Quality of care for elderly residents in nursing homes and elderly people living at home: controlled observational study. Fahey T, Montgomery AA, Barnes J, Protheroe J, BMJ 2003 326 580 10.1136/bmj.326.7389.580 12637404
12. Multidisciplinary medication review in nursing home residents: what are the most significant drug-related problems? The Bergen District Nursing Home (BEDNURS) study. Ruths S, Straand J, Nygaard HA, Qual Saf Health Care 2003 12 176 180 10.1136/qhc.12.3.176 12792006 (Pubitemid 36723943)
13. The quality of antipsychotic drug prescribing in nursing homes. Briesacher BA, Limcangco MR, Simoni-Wastila L, Doshi JA, Levens SR, Shea DG, Stuart B, Arch Inter Med 2005 165 1280 1285 10.1001/archinte.165.11.1280 (Pubitemid 40989593)
14. Variation in nursing home antipsychotic prescribing rates. Rochon PA, Stukel TA, Bronskill SE, Gomes T, Sykora K, Wodchis WP, Hillmer M, Kopp A, Gurwitz JH, Anderson GM, Arch Intern Med 2007 167 676 683 10.1001/archinte.167. 7.676 17420426 (Pubitemid 46598460)
15. Exposure to potentially inappropriate drugs and drug-drug interactions in elderly nursing home residents in Helsinki, Finland: A cross-sectional study. Hosia-Randell H, Muurinen SM, Pitkälä KH, Drugs Aging 2008 25 683-692
16. Antipsychotic drug use among elderly nursing home residents in the United States. Kamble P, Chen H, Sherer J, Aparasu RR, Am J Geriatr Pharmacother 2008 6 187 197 10.1016/j.amjopharm.2008.10.002 19028374
17. Psychotropic medication use among nursing home residents in Austria: a cross-sectional study. Mann E, Kopke S, Haastert B, Pitkälä K, Meyer G, BMC Geriatr 2009 9 18 10.1186/1471-2318-9-18 19460135
18. Psychotropic drug use in elderly people with and without dementia. Giron MS, Forsell Y, Bernsten C, Thorslund M, Winblad B, Fastbom J, Int J Geriatr Psychiatry 2001 9 900 906 (Pubitemid 32926775)
19. Use of psychotropic drugs in elderly nursing home residents with and without dementia in Helsinki, Finland. Hosia-Randell H, Pitkälä K, Drugs Aging 2005 22 793 800 10.2165/00002512-200522090-00008 16156683
20. Use of psychotropics among home-dwelling nondemented and demented elderly. Hartikainen S, Rahkonen T, Kautiainen H, Sulkava R, Int J Geriatr Psychiatry 2003 18 1135 1141 10.1002/gps.1024 14677146 (Pubitemid 38049247)
21. The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes. Selbaek G, Kirkevold Engedal K, Int J Geriatr Psychiatry 2007 22 843 849 10.1002/gps.1749 17193341 (Pubitemid 47455265)
22. Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Cao YJ, Mager DE, Simonsick EM, Hilmer SN, Ling SM, Windham BG, Crentsil V, Yasar S, Fried LP, Abernethy DR, Clin Pharmacol Ther 2008 83 422 429 10.1038/sj.clpt.6100303 17713474 (Pubitemid 351272629)
23. Drug Burden Index and physical function in older Australian men. Gnjidic D, Cumming RG, Le Couteur DG, Handelsman DJ, Naganathan V, Abernethy DR, Hilmer SN, Br J Clin Pharmacol 2009 68 97 105 10.1111/j.1365-2125.2009.03411.x 19660007
24. Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition Study. Hanlon JT, Boudreau RM, Roumani YF, Newman AB, Ruby CM, Wright RM, Hilmer SN, Shorr RI, Bauer DC, Simonsick EM, Studenski SA, J Gerontol A Biol Sci Med Sci 2009 64 492 498 19196642
25. A drug burden index to define the functional burden of medication in older people. Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, Harris TB, Hanlon JT, Rubin SM, Shorr RI, Bauer DC, Abernethy DR, Arch Intern Med 2007 167 781 787 10.1001/archinte.167.8.781 17452540 (Pubitemid 46658335)
26. Accounting for the sedative and analgesic effects of medication changes during patient participation in clinical research studies: measurement development and application to a sample of institutionalized geriatric patients. Sloane P, Ivey J, Roth M, Roederer M, Williams CS, Contemp Clin Trials 2008 29 140 148 10.1016/j.cct.2007.06.004 17683997 (Pubitemid 351248761)
27. Associations between drug burden index and falls in older people in residential aged care. Wilson NM, Hilmer SN, March LM, Cameron ID, Lord SR, Seibel MJ, Mason RS, Chen JS, Cumming RG, Sambrook PN, J Am Geriatr Soc 2011 59 875 880 10.1111/j.1532-5415.2011.03386.x 21539525
28. Effect of central nervous system medication use on decline in cognition in community-dwelling older adults: findings from the Health, Aging and Body Composition Study. Wright RM, Roumani YF, Boudreau R, Newman AB, Ruby CM, Studenski SA, Shorr RI, Bauer DC, Simonsick EM, Hilmer SN, Hanlon JT, and for the Health Aging and Body Composition Study, J Am Geriatr Soc 2009 57 243 250 10.1111/j.1532-5415.2008.02127.x 19207141
29. Central nervous system medication use and incident mobility limitation in community elders: the Health, Aging, and Body Composition Study. Boudreau RM, Hanlon JT, Roumani YF, Studenski SA, Ruby CM, Wright RM, Hilmer SN, Shorr RI, Bauer DC, Simonsick EM, Newman AB, Pharmacoepidemiol Drug Saf 2009 18 916 92 10.1002/pds.1797 19585466
30. Drug burden index score and functional decline in older people. Hilmer SN, Mager DE, Simonsick EM, Ling SM, Windham BG, Harris TB, Shorr RI, Bauer DC, Abernethy DR, Health ABC Study, Am J Med 2009 122 1142 1149 10.1016/j.amjmed. 2009.02.021 19958893
31. Associations between drug burden index and physical function in older people in residential aged care facilities. Wilson NM, Hilmer SN, March LM, Cameron ID, Lord SR, Seibel MJ, Sambrook PN, Age Ageing 2010 39 503 507 10.1093/ageing/afq053 20501606
32. A comparison of four methods to quantify the cumulative effect of taking multiple drugs with sedative properties. Taipale HT, Hartikainen S, Bell JS, Am J Geriatr Pharmacother 2010 8 460 471 10.1016/j.amjopharm.2010.10.004 21335299
33. Sedative load and mortality among residents of long-term care facilities: a prospective cohort study. Taipale HT, Bell JS, Soini H, Pitkälä KH, Drugs Aging 2009 26 871 881 10.2165/11317080-000000000-00000 19761280
34. Sedative load among long-term care facility residents with and without dementia: a cross-sectional study. Bell JS, Taipale HT, Soini H, Pitkälä KH, Clin Drug Investig 2010 30 63 70 10.2165/11531460- 000000000-00000 19995099
35. Sedative drug use in the home dwelling elderly. Linjakumpu TA, Hartikainen SA, Klaukka TJ, Koponen HJ, Hakko HH, Viilo KM, Haapea M, Kivelä SL, Isoaho RE, Ann Pharmacother 2004 38 2017 2022 10.1345/aph.1E067 15507503 (Pubitemid 40169368)
36. A model to classify the sedative load of drugs. Linjakumpu T, Hartikainen S, Klaukka T, Koponen H, Kivelä SL, Isoaho R, Int J Geriatr Psychiatry 2003 18 542 544 10.1002/gps.846 12789678 (Pubitemid 36763660)
37. Impact of residential medication management reviews on Drug Burden Index in aged-care homes. Nishtala PS, Hilmer SN, McLachlan AJ, Hannan PJ, Chen TF, Drugs Aging 2009 26 677 686 10.2165/11316440-000000000-00000 19685933
38. Determinants of antipsychotic medication use among older people living in aged care homes in Australia. Nishtala PS, McLachlan AJ, Bell JS, Chen TF, Int J Geriatr Psychiatry 2010 25 449 457 10.1002/gps.2359 19670391
39. Culture, consent, costs and care homes: enabling older people with dementia to participate in research. Goodman C, Baron NL, Machen I, Stevenson E, Evans C, Davies SL, Iliffe S, Aging Ment Health 2011 15 475 481 10.1080/13607863.2010.543659 21500014
40. The Anatomical Therapeutic Chemical Classification System. WHO Collaborating Centre for Drug Statistics Methodology., Norwegian Institute of Public Health [online] 2008 http://www.whocc.no/atc-ddd-index/ (accessed 24 January 2011).
41. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. Folstein MF, Folstein S, McHugh PR, J Psychiatr Res 1975 12 189 198 10.1016/0022-3956(75)90026-6 1202204
42. Cornell scale for depression in dementia. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA, Biol Psychiatry 1988 23 271 284 10.1016/0006-3223(88) 90038-8 3337862 (Pubitemid 18047596)
43. National Service Framework for Older People. Department of Health., London: Department of Health 2001 http://www.dh.gov.uk/prod-consum-dh/groups/dh- digitalassets/@dh/@en/documents/digitalasset/dh-4067247.pdf (accessed 3 February 2011)
44. Instruction Manual for the Cohen-Mansfield Agitation Inventory (CMAI). Cohen-Mansfield J, The Research Institute of the Hebrew Home of Greater Washington, Rockville 1991
45. Factors associated with psychotropic drug usage among nursing home residents with dementia. Kim H, Whall AL, Nurs Research 2006 55 252 258 10.1097/00006199-200607000-00005 (Pubitemid 44503656)
46. Behavioural symptoms and the administration of psychotropic drugs to aged patients with dementia in nursing homes and in acute geriatric wards. Pitkala KH, Laurila JV, Strandberg TE, Tilvis RS, Int Psychogeriatr 2004 16 61 74 10.1017/S1041610204000079 15190997 (Pubitemid 38849977)
47. Psychotropic drug use in elderly people with and without dementia. Giron MS, Forsell Y, Bernsten C, Thorslund M, Winblad B, Fastbom J, Int J Geriatr Psychiatry 2001 16 900 906 10.1002/gps.438 11571771 (Pubitemid 32926775)
48. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH, Arch Intern Med 2003 163 2716 2724 10.1001/archinte.163.22.2716 14662625 (Pubitemid 37517412)
49. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. Sink KM, Holden KF, Yaffe K, JAMA 2005 293 596 608 10.1001/jama.293.5.596 15687315 (Pubitemid 40171242)
50. Management of verbally disruptive behaviours in nursing home residents. Cohen-Mansfield J, Werner P, J Gerontol A Biol Sci Med Sci 1997 52 369 M377 9402944
51. Effective behavioural interventions for decreasing dementia-related challenging behavior in nursing homes. Allen-Berge R, Stevens AB, Burgio LD, Int J Geriatr Psychiatry 1999 14 213 228 10.1002/(SICI)1099-1166(199903)14: 3<213::AID-GPS974>3.0.CO;2-0 10202663
52. Behavioural symptoms of dementia in residential settings: A selective review of non-pharmacological interventions. Turner S, Aging Ment Health 2005 9 93 104 10.1080/13607860512331339090 15804626 (Pubitemid 40516341)
53. Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia. Livingston G, Johnston K, Katona C, Paton J, Lyketsos CG, Old Age Task Force of the World Federation of Biological Psychiatry, Am J Geriatr Psychiatry 2005 196 1996 2021 (Pubitemid 41598254)
54. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial. Fossey J, Ballard C, Juszczak E, James I, Alder N, Jacoby R, Howard R, BMJ 2006 332 756 758 10.1136/bmj.38782.575868.7C 16543297 (Pubitemid 44365651)
55. Nonpharmacological treatment of agitation: a controlled trial of systematic individualized intervention. Cohen-Mansfield J, Libin A, Marx MS, J Gerontol A Biol Sci Med Sci 2007 62 908 916 17702884 (Pubitemid 350139005)
56. Brief Psychosocial Therapy for the Treatment of Agitation in Alzheimer Disease (The CALM-AD Trial). Ballard C, Brown R, Fossey J, Douglas S, Bradley P, Hancock J, James IA, Juszczak E, Bentham P, Burns A, Lindesay J, Jacoby R, O'Brien J, Bullock R, Johnson T, Holmes C, Howard R, Am J Geriatr Pharmacother 2009 17 726 733
57. Non-pharmacological management of behavioural symptoms in nursing homes. Deudon A, Maubourguet N, Gervais X, Leone E, Brocker P, Carcaillon L, Riff S, Lavallart B, Robert PH, Int J Geriatr Psychiatry 2009 24 1386 1395 10.1002/gps.2275 19370714
58. Nonpharmacological intervention for agitation in dementia: a systematic review and meta-analysis. Kong EH, Evans LK, Guevara JP, Aging Ment Health 2009 13 512 520 10.1080/13607860902774394 19629775
59. Psychosocial treatments of behavior symptoms in dementia: a systematic review of reports meeting quality standards. O'Connor DW, Ames D, Gardner B, King M, Inter Psychogeriatr 2009 21 225 240 10.1017/S1041610208007588
60. Psychosocial treatments of psychological symptoms in dementia: a systematic review of reports meeting quality standards. O'Connor DW, Ames D, Gardner B, King M, Int Psychogeriatr 2009 21 241 251 10.1017/S1041610208008223 19138459
61. Psychosocial interventions in dementia care in long term care. Vernooij-Dassen M, Vasse E, Zuidema S, Cohen-Mansfield J, Moyle W, Int Psychogeriatr 2010 22 1121 8 10.1017/S1041610210001365 20813074
62. Can agitated behavior of nursing home residents with dementia be prevented with the use of standardized stimuli? Cohen-Mansfield J, Marx MS, Dakheel-Ali M, Regier NG, Thein K, Freedman L, J Am Geriatr Soc 2010 58 1459 1464 10.1111/j.1532-5415.2010.02951.x 20579167
63. Guidelines for psychosocial interventions in dementia care: a European survey and comparison. Vasse E, Vernooij-Dassen M, Cantegril I, Franco M, Dorenlot P, Woods B, Moniz-Cook E, Int J Geriatr Psychiatry 2011 2 Mar 2011