Protective effect of novel pyridoindole derivatives on ischemia/reperfusion injury of the isolated rat heart

Pharmacological Reports

Volumn 63, Issue 4, 2011, Pages 967-974

  Broskova, Zuzana ^a   Knezl, Vladimir ^a  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

Author keywords

Dysrhythmias; Ischemia reperfusion; Isolated heart; Pyridoindole; Stobadine

Indexed keywords

2 ETHOXYCARBONYL 8 METHOXY 2,3,4,4A,5,9B HEXAHDYRO 1H PYRIDO[4,3 B]INDOLINIUM DICHLORIDE; 8 METHOXY 2,3,4,4A,5,9B HEXAHDYRO 1H PYRIDO[4,3 B]INDOLINIUM DICHLORIDE; CARBOLINE DERIVATIVE; STOBADINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; ISOLATED HEART; LEFT VENTRICULAR DEVELOPED PRESSURE; MALE; NONHUMAN; PHARMACODYNAMICS; RAT; REPERFUSION INJURY; STUNNED HEART MUSCLE;

EID: 80053362354     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70612-0     Document Type: Article

References (31)

1. Bastide M, Ouk T, Plaisier F, Petrault O, Stolc S, Bordet R: Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target. Psychoneuroendocrinology, 2007, 32, S36-S39. (Pubitemid 47211634)
2. Bolli R, Marban E: Molecular and cellular mechanisms of myocardial stunning. Physiol Rev, 1999, 79, 609-634. (Pubitemid 29210931)
3. Curtis MJ, Walker MJ: Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischaemia. Cardiovasc Res, 1988, 22, 656-665.
4. Gibala P, Sotnikova R, Drimal J: Antiarrhythmic effect of DH 1011. Bratisl Med J, 1985, 84, 137-144.
5. Jeroudi MO, Hartley GJ, Bolli R: Myocardial reperfusion injury: role of oxygen radicals and potential therapy with antioxidants. Am J Cardiol, 1994, 73, B2-B7. (Pubitemid 124007804)
6. Juranek I, Horakova L, Rackova L, Stefek M: Antioxidants in treating pathologies involving oxidative damage: an update on medicinal chemistry and biological activity of stobadine and related pyridoindoles. Cur Med Chem, 2010, 17, 552-570.
7. th September 2006, 106.
8. Knezl V, Sotnikova R, Drimal J: Effect of stobadine on functional parametres of rat heart. Czecoslov Physiol, 2001, 50, 164.
9. Knezl V, Sotnikova R, Okruhlicova L, Navarova J: Effect of stobadine on cardiac injury induced by ischemia and reperfusion. Life Sciences, 1999, 65, 1931-1933. (Pubitemid 29506931)
10. Kumar S, Hall RJC, Mani AR, Moore KP, Camici PG, Rimoldi OE, Williams AJ, Macleod KT: Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. Biochem Biophys Res Commun, 2009, 387, 77-82.
11. Kyselova Z, Gajdosik A, Gajdosikova A, Ulicna O, Mihalova D, Karasu C, Stefek M: Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. Mol Vis, 2005, 11, 56-65. (Pubitemid 41358308)
12. Lepran I, Szekeres L: Effect of dietary sunflower seed oil on the severity of reperfusion-induced arrhythmias in anesthetized rats. J Cardiovasc Pharmacol, 1992, 19, 40-44.
13. Liem DA, Honda HM, Zhang J,Woo D, Ping P: Past and present course of cardioprotection against ischemiare-perfusion injury. J Appl Physiol, 2007, 103, 2129-2136. (Pubitemid 350232399)
14. Maxwell SRJ, Lip GYH: Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int J Cardiol, 1997, 58, 95-117. (Pubitemid 27064668)
15. Moens AL, Claeys MJ, Timmermans JP: Myocardial ischemia/reperfusion- injury, a clinical view on a complex pathophysiological process. Int J Cardiol, 2005, 100, 179-190.
16. Monassier JP: Reperfusion injury in acute myocardial infarction. From bench to cath lab. Part I: Basic considerations. Arch Cardiovasc Dis, 2008, 101, 491-500.
17. Ostadal B: The past, the present and the future of experimental research on myocardial ischemia and protection. Pharmacol Rep, 2009, 61, 3-12.
18. Piper HM, Garcia-Dorado D, Ovize M: A fresh look at reperfusion injury. Cardiovasc Res, 1998, 38, 291-300. (Pubitemid 28294147)
19. Plaisier F, Bastide M, Ouk T, Petrault O, Lapais M, Stolc S, Bordet R: Stobadine-induced hastening of sensomotor recovery after focal ischemia/reperfusion is associated with cerebrovascular protection. Brain Res, 2008, 1208, 240-249.
20. Rackova L, Snirc V, Majekova M, Majek P, Stefek M: Free radical scavenging and antioxidant activities of substituted hexahydropyridoindoles. Quantitative structure -activity relationship. J Med Chem, 2006, 46, 2543-2548.
21. Skalska S, Kucera P, Goldenberg Z, Stefek M, Kyselova Z, Jariabka P, Gajdosikova A et al: Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose α-lipoic acid treatment. Gen Physiol Biophys, 2010, 29, 50-58.
22. Skalska S, Kyselova Z, Gajdosikova A, Carasu C, Stefek M, Stolc S: Protective effect of stobadine on NCV in streptozotocin-diabetic rats: augmentation by vitamin E. Gen Physiol Biophys, 2008, 27, 106-114.
23. Stasko A, Ondrias K, Misik V, Szocsova H, Gergel D: Stobadine - a novel scavenger of free radicals. Chem Pap, 1990, 44, 493-500.
24. Steenken S, Sundquist AR, Jovanovic SV, Crockett R, Sies H: Antioxidant activity of the pyridoindole stobadine - pulse radiolytic characterisation of one-electronoxidized stobadine and quenching of singlet molecularoxygen. Chem Res Toxicol, 1992, 5, 355-360.
25. Stolc S, Bauer V, Benes L, Tichy M: Medicine with antiarrhythmic and antihypoxic activity and its method of preparation. Patents: CS 229 067, SWED. 8204693-9, BELG. 894148, SWISS 651 754, BRD P-3231088, SPAIN 553 017, JAP. 151 4040. 1983.
26. Stolc S, Povazanec F, Bauer V, Majekova M, Wilcox AL, Snirc V, Rackova L et al. Slovak Patent Registration PP 1321, 2003.
27. Stolc S, Snirc V, Majekova M, Gasparova Z, Gajdosikova A, Stvrtina S: Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress. Cell Mol Neurobiol, 2006, 26, 1495-1504. (Pubitemid 44924062)
28. Ujhazy E, Dubovicky M, Balonova T, Jansak J: Teratological study of the antioxidant stobadine in rats. Gen Physiol Biophys, 1999, 18, 171-176.
29. www.molinspiration.com/cgi-bin/properties
30. Zurova-Nedelcevova J, Navarova J, Drabikova K, Jancinova V, Petrikova M, Bernatova I, Kristova V et al: Participation of reactive oxygen species in diabetes-induced endothelial dysfunction. Neuroendocrin Lett, 2006, 27, 168-171. (Pubitemid 46534365)
31. Zweier JL, Talukder MAH: The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res, 2006, 70, 181-190.