Therapeutic efect of total ginseng saponin on skin wound healing

Journal of Ginseng Research

Volumn 35, Issue 3, 2011, Pages 360-367

  Kim, Young Soo ^a   Cho, Ik Hyun ^b   Jeong, Moon Jin ^c   Jeong, Soon Jeong ^c   Nah, Seung Yeol ^d   Cho, Young Sik ^e   Kim, Seung Hyun ^a   Go, Ara ^a   Kim, Se Eun ^a   Kang, Seong Soo ^a   Moon, Chang Jong ^a   Kim, Jong Choon ^a   Kim, Sung Ho ^a   Bae, Chun Sik ^a  

^a Chonnam National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Chosun University   (South Korea)

^d Konkuk University   (South Korea)

^e Namseoul University   (South Korea)

Author keywords

Mice; Panax ginseng; Skin wound healing; Total ginseng saponin

Indexed keywords

MUS; PANAX GINSENG;

EID: 80053361623     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2011.35.3.360     Document Type: Article

References (33)

1. Stephens P, Thomas DW. The cellular proliferative phase of the wound repair process. J Wound Care 2002;11:253-261.
2. Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 2007; 127:998-1008.
3. Blazso G, Gabor M, Schonlau F, Rohdewald P. Pycno-genol accelerates wound healing and reduces scar formation. Phytother Res 2004;18:579-581.
4. Guclu-Ustundag O, Mazza G. Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 2007;47:231-258.
5. Baumann E, Stoya G, Volkner A, Richter W, Lemke C, Linss W. Hemolysis of human erythrocytes with sa-ponin affects the membrane structure. Acta Histochem 2000;102:21-35.
6. Oda K, Matsuda H, Murakami T, Katayama S, Ohgitani T, Yoshikawa M. Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants. Biol Chem 2000;38:67-74.
7. Killeen GF, Madigan CA, Connolly CR, Walsh GA, Clark C, Hynes MJ, Timmins BF, James P, Headon DR, Power RF. Antimicrobial saponins of Yucca schidigera and the implications of their in vitro properties for their in vivo impact. J Agric Food Chem 1998;46:3178-3186.
8. Konishi M, Hano Y, Takayama M, Nomura T, Hamzah AS, Ahmad RB, Jamani H. Triterpenoid saponins from Hedyotis nudicaulis. Phytochemistry 1998;48:525-528.
9. Simoes CM, Amoros M, Girre L. Mechanism of antiviral activity of triterpenoid saponins. Phytother Res 1999; 13:323-328.
10. Apers S, Baronikova S, Sindambiwe JB, Witvrouw M, De Clercq E, Vanden Berghe D, Van Marck E, Vlietinck A, Pieters L. Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: establishment of structure-activity relationships. Planta Med 2001;67:528-532.
11. Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr Med Chem 2005;12:657-666.
12. Just MJ, Recio MC, Giner RM, Cuéllar MJ, Máñez S, Bilia AR, Ríos JL. Anti-infammatory activity of unusual lupane saponins from Bupleurum fruticescens. Planta Med 1998;64:404-407.
13. Navarro P, Giner RM, Recio MC, Manez S, Cerda-Nicolas M, Ríos JL. In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium. Life Sci 2001;68:1199-1206.
14. Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M. Effects of ginseng saponins isolated from red ginseng roots on burn wound healing in mice. Br J Pharmacol 2006;148:860-870.
15. Wang ZY, Zhang J, Lu SL. Objective evaluation of burn and post-surgical scars and the accuracy of subjective scar type judgment. Chin Med J (Engl) 2008;121:2517-2520.
16. Guan DW, Ohshima T, Kondo T. Immunohistochemical study on Fas and Fas ligand in skin wound healing. Histo-chem J 2000;32:85-91.
17. Clark RA. Wound repair: overview and general considerations. In: Clark RA, Henson PM. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press, 1996. p.513-560.
18. Toriseva M, Kahari VM. Proteinases in cutaneous wound healing. Cell Mol Life Sci 2009;66:203-224.
19. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341:738-746.
20. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514-525.
21. Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gab-biani G. Mechanical tension controls granulation tissue contractile activity and myofbroblast differentiation. Am J Pathol 2001;159:1009-1020.
22. Hinz B. Formation and function of the myofbroblast during tissue repair. J Invest Dermatol 2007;127:526-537.
23. Kang JS. Cosmetic surgery. 3rd ed. Seoul: Kunga Press, 2004.
24. Hsu S. Green tea and the skin. J Am Acad Dermatol 2005;52:1049-1059.
25. Rice-Evans CA, Miller NJ, Paganga G. Structure-anti-oxidant activity relationships of favonoids and phenolic acids. Free Radic Biol Med 1996;20:933-956.
26. Packer L, Rimbach G, Virgili F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 1999;27:704-724.
27. Babior BM. Phagocytes and oxidative stress. Am J Med 2000;109:33-44.
28. Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002;957:239-249.
29. Sparg SG, Light ME, van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmacol 2004;94:219-243.
30. Ramzy PI, Barret JP, Herndon DN. Thermal injury. Crit Care Clin 1999;15:333-352, ix.
31. Choi S. Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2. Arch Pharm Res 2002;25:71-76.
32. Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y. Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice. Eur J Pharmacol 2009;602:148-156.
33. Lee J, Jung E, Lee J, Huh S, Kim J, Park M, So J, Ham Y, Jung K, Hyun CG et al. Panax ginseng induces human type I collagen synthesis through activation of Smad signaling. J Ethnopharmacol 2007;109:29-34.