Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: Role of pH

BMC Microbiology

Volumn 11, Issue , 2011, Pages

  Romanowski, Kathleen ^a   Zaborin, Alexander ^a   Fernandez, Hoylan ^a,c   Poroyko, Valeriy ^a   Valuckaite, Vesta ^a   Gerdes, Svetlana ^b   Liu, Donald C ^a   Zaborina, Olga Y ^a   Alverdy, John C ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Fellowship for Interpretation of Genomes   (United States)

^c ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; PHOSPHATE; SIDEROPHORE; BACTERIAL PROTEIN;

ACIDITY; ALKALINITY; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL VIRULENCE; CAENORHABDITIS ELEGANS; CRITICALLY ILL PATIENT; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIGH RISK PATIENT; INOCULATION; INTESTINE INFECTION; MALE; MICROARRAY ANALYSIS; MORTALITY; MOUSE; NONHUMAN; PH MEASUREMENT; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SURGICAL INJURY; VITAMIN SUPPLEMENTATION; ANIMAL; C57BL MOUSE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTESTINE; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PH; VIRULENCE;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; MUS;

ANIMALS; BACTERIAL PROTEINS; CAENORHABDITIS ELEGANS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINES; IRON; MALE; MICE; MICE, INBRED C57BL; PHOSPHATES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SEPSIS; SIDEROPHORES; VIRULENCE;

EID: 80053354044     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-11-212     Document Type: Article

References (47)

1. Altered gut flora and environment in patients with severe SIRS. Shimizu K, Ogura H, Goto M, Asahara T, Nomoto K, Morotomi M, Yoshiya K, Matsushima A, Sumi Y, Kuwagata Y, et al. J Trauma 2006 60 1 126 133 10.1097/01.ta.0000197374. 99755.fe 16456446
2. Dramatic Changes of the Gut Flora Immediately After Severe and Sudden Insults. Hayakawa M, Asahara T, Henzan N, Murakami H, Yamamoto H, Mukai N, Minami Y, Sugano M, Kubota N, Uegaki S, et al. Dig Dis Sci 2011 58 8 2361 2365
3. International study of the prevalence and outcomes of infection in intensive care units. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, et al. Jama 2009 302 21 2323 2329 10.1001/jama.2009.1754 19952319
4. Translocation of Pseudomonas aeruginosa from the intestinal tract is mediated by the binding of ExoS to an Na, K-ATPase regulator, FXYD3. Okuda J, Hayashi N, Okamoto M, Sawada S, Minagawa S, Yano Y, Gotoh N, Infect Immun 78 11 4511 4522
5. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System. Wu L, Holbrook C, Zaborina O, Ploplys E, Rocha F, Pelham D, Chang E, Musch M, Alverdy J, Ann Surg 2003 238 5 754 764 10.1097/01.sla.0000094551.88143.f8 14578740 (Pubitemid 38182269)
6. Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier. Zaborina O, Kohler JE, Wang Y, Bethel C, Shevchenko O, Wu L, Turner JR, Alverdy JC, Ann Clin Microbiol Antimicrob 2006 5 14 10.1186/1476-0711-5-14 16762075 (Pubitemid 44083833)
7. Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa. Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC, PLoS Pathog 2008 4 2 43 10.1371/journal.ppat.0040043 18282104 (Pubitemid 351340709)
8. Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis. Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J, Surgery 2008 144 2 189 197 10.1016/j.surg.2008.03.045 18656625 (Pubitemid 352010322)
9. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Zaborin A, Romanowski K, Gerdes S, Holbrook C, Lepine F, Long J, Poroyko V, Diggle SP, Wilke A, Righetti K, et al. Proc Natl Acad Sci USA 2009 106 15 6327 6332 10.1073/pnas.0813199106 19369215
10. Host Stress and Virulence Expression in Intestinal Pathogens: Development of Therapeutic Strategies using Mice and C. elegans. Zaborina O, Zaborin A, Romanowski K, Babrowski T, Alverdy J, Curr Pharm Des 2011 17 13 1254 1260 21470113
11. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Nugent SG, Kumar D, Rampton DS, Evans DF, Gut 2001 48 4 571 577 10.1136/gut.48.4.571 11247905 (Pubitemid 32234805)
12. Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Bown RL, Gibson JA, Sladen GE, Hicks B, Dawson AM, Gut 1974 15 12 999 1004 10.1136/gut.15.12.999 4448417
13. Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease. Ewe K, Schwartz S, Petersen S, Press AG, Dig Dis Sci 1999 44 7 1434 1439 10.1023/A:1026664105112 10489931 (Pubitemid 29404310)
14. Gastrointestinal pH profiles in patients with inflammatory bowel disease. Press AG, Hauptmann IA, Hauptmann L, Fuchs B, Fuchs M, Ewe K, Ramadori G, Aliment Pharmacol Ther 1998 12 7 673 678 10.1046/j.1365-2036.1998.00358.x 9701532 (Pubitemid 28327965)
15. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Evans DF, Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD, Gut 1988 29 8 1035 1041 10.1136/gut.29.8.1035 3410329
16. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Alverdy J, Holbrook C, Rocha F, Seiden L, Wu RL, Musch M, Chang E, Ohman D, Suh S, Ann Surg 2000 232 4 480 489 10.1097/00000658-200010000-00003 10998646
17. Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients. Wagner T, Soong G, Sokol S, Saiman L, Prince A, Chest 2005 128 2 912 919 10.1378/chest.128.2.912 16100186 (Pubitemid 41140526)
18. The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis. Laughlin RS, Musch MW, Hollbrook CJ, Rocha FM, Chang EB, Alverdy JC, Ann Surg 2000 232 1 133 142 10.1097/00000658-200007000-00019 10862206 (Pubitemid 30456561)
19. Quorum-sensing and siderophore biosynthesis in Pseudomonas aeruginosa: lasR/lasI mutants exhibit reduced pyoverdine biosynthesis. Stintzi A, Evans K, Meyer JM, Poole K, FEMS Microbiol Lett 1998 166 2 341 345 10.1111/j.1574-6968. 1998.tb13910.x 9770291 (Pubitemid 128384180)
20. The QscR quorum-sensing regulon of Pseudomonas aeruginosa: an orphan claims its identity. Fuqua C, J Bacteriol 2006 188 9 3169 3171 10.1128/JB.188.9.3169-3171.2006 16621807
21. QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Chugani SA, Whiteley M, Lee KM, D'Argenio D, Manoil C, Greenberg EP, Proc Natl Acad Sci USA 2001 98 5 2752 2757 10.1073/pnas.051624298 11226312 (Pubitemid 32209555)
22. Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor. Lee JH, Lequette Y, Greenberg EP, Mol Microbiol 2006 59 2 602 609 10.1111/j.1365-2958.2005.04960.x 16390453
23. Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR. Ledgham F, Ventre I, Soscia C, Foglino M, Sturgis JN, Lazdunski A, Mol Microbiol 2003 48 1 199 210 10.1046/j.1365-2958.2003.03423.x 12657055 (Pubitemid 36411477)
24. Arginine deiminase system and acid adaptation of oral streptococci. Curran TM, Lieou J, Marquis RE, Appl Environ Microbiol 1995 61 12 4494 4496 8534118
25. Kinetics of expression of the Escherichia coli cad operon as a function of pH and lysine. Neely MN, Olson ER, J Bacteriol 1996 178 18 5522 5528 8808945 (Pubitemid 26304389)
26. Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli. Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K, Mol Microbiol 2004 51 5 1401 1412 10.1046/j.1365-2958. 2003.03913.x 14982633 (Pubitemid 38338901)
27. Total alkalinity: The explicit conservative expression and its application to biogeochemical processes. Wolf-Gladrow, Dieter A, Zeebe, Richard E, Klaas, Christine, Körtzinger, Arne and Dickson, Andrew G, Marine Chemistry 2007 106 1-2 287 300 10.1016/j.marchem.2007.01.006 (Pubitemid 47211587)
28. The effect of oxygen on denitrification in Paracoccus denitrificans and Pseudomonas aeruginosa. Davies KJ, Lloyd D, Boddy L, J Gen Microbiol 1989 135 9 2445 2451 2516869 (Pubitemid 19238445)
29. Aerobic denitrification of Pseudomonas aeruginosa monitored by online NAD(P)H fluorescence. Chen F, Xia Q, Ju LK, Appl Environ Microbiol 2003 69 11 6715 6722 10.1128/AEM.69.11.6715-6722.2003 14602632 (Pubitemid 37420209)
30. Oxygen, cyanide and energy generation in the cystic fibrosis pathogen Pseudomonas aeruginosa. Williams HD, Zlosnik JE, Ryall B, Adv Microb Physiol 2007 52 1 71 17027370
31. Bacterial respiration: a flexible process for a changing environment. Richardson DJ, Microbiology 2000 146 Pt 3 551 571 10746759
32. Role of the arginine deiminase system in protecting oral bacteria and an enzymatic basis for acid tolerance. Casiano-Colon A, Marquis RE, Appl Environ Microbiol 1988 54 6 1318 1324 2843090
33. GeneChip expression analysis of the iron starvation response in Pseudomonas aeruginosa: identification of novel pyoverdine biosynthesis genes. Ochsner UA, Wilderman PJ, Vasil AI, Vasil ML, Mol Microbiol 2002 45 5 1277 1287 10.1046/j.1365-2958.2002.03084.x 12207696 (Pubitemid 35015352)
34. A clinical index predicting mortality with Pseudomonas aeruginosa bacteraemia. Aliaga L, Mediavilla JD, Cobo F, J Med Microbiol 2002 51 7 615 619 12132781 (Pubitemid 34747994)
35. Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units. Bertrand X, Thouverez M, Talon D, Boillot A, Capellier G, Floriot C, Helias JP, Intensive Care Med 2001 27 8 1263 1268 10.1007/s001340100979 11511937 (Pubitemid 32758922)
36. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away. Alverdy JC, Chang EB, J Leukoc Biol 2008 83 3 461 466 18160538 (Pubitemid 351966851)
37. The gut flora as a forgotten organ. O'Hara AM, Shanahan F, EMBO Rep 2006 7 7 688 693 10.1038/sj.embor.7400731 16819463 (Pubitemid 43986264)
38. The role of the intestinal microbiota in enteric infection. Sekirov I, Finlay BB, J Physiol 2009 587 Pt 17 4159 4167 19491248
39. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, Finlay BB, Cell Host Microbe 2007 2 2 119 129 10.1016/j.chom.2007.06.010 18005726 (Pubitemid 47209521)
40. Induction of colonic regulatory T cells by indigenous Clostridium species. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, et al. Science 331 6015 337 341
41. Role of iron in anaemic critically ill patients: it's time to investigate! Piagnerelli M, Vincent JL, Crit Care 2004 8 5 306 307 10.1186/cc2884 15469585 (Pubitemid 39468044)
42. Erythropoietin-induced rheological changes of rat erythrocytes. Bor-Kucukatay M, Yalcin O, Meiselman HJ, Baskurt OK, Br J Haematol 2000 110 1 82 88 10.1046/j.1365-2141.2000.02150.x 10930982 (Pubitemid 30625596)
43. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. Casadevall N, Nataf J, Viron B, Kolta A, Kiladjian JJ, Martin-Dupont P, Michaud P, Papo T, Ugo V, Teyssandier I, et al. N Engl J Med 2002 346 7 469 475 10.1056/NEJMoa011931 11844847 (Pubitemid 34441737)
44. Iron and infection. Patruta SI, Horl WH, Kidney Int Suppl 1999 69 125 130 10084296
45. Pathobiology of the role of iron in infection. Sunder-Plassmann G, Patruta SI, Horl WH, Am J Kidney Dis 1999 34 4 Suppl 2 25 29 10516372
46. Association of hepatic iron overload with invasive fungal infection in liver transplant recipients. Alexander J, Limaye AP, Ko CW, Bronner MP, Kowdley KV, Liver Transpl 2006 12 12 1799 1804 10.1002/lt.20827 16741903 (Pubitemid 44911806)
47. Association of hemochromatosis with infectious diseases: expanding spectrum. Khan FA, Fisher MA, Khakoo RA, Int J Infect Dis 2007 11 6 482 487 10.1016/j.ijid.2007.04.007 17600748 (Pubitemid 47626050)