Alzheimer disease pathology in subjects without dementia in 2 studies of aging: The nun study and the adult changes in thought study

Journal of Neuropathology and Experimental Neurology

Volumn 70, Issue 10, 2011, Pages 832-840

  Santacruz, Karen S ^a   Sonnen, Joshua A ^b   Pezhouh, Maryam Kherad ^a   Desrosiers, Mark F ^a   Nelson, Peter T ^c   Tyas, Suzanne L ^d  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Adult Changes in Thought study; Alzheimer disease; Brain reserve; Dementia; Nun Study; Preclinical; Presymptomatic

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CLERGY; COGNITIVE DEFECT; COMPARATIVE STUDY; DEMENTIA; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MEMORY DISORDER; NEOCORTEX; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; APOLIPOPROTEINS E; BRAIN; COGNITION DISORDERS; DEMENTIA; FEMALE; HUMANS; LEWY BODIES; LONGITUDINAL STUDIES; MALE; NEUROFIBRILLARY TANGLES; NEUROPSYCHOLOGICAL TESTS; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC;

EID: 80053352053     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31822e8ae9     Document Type: Article

References (40)

1. Stern Y. Cognitive reserve. Neuropsychologia 2009;47:2015-28
2. Bennett DA, Schneider JA, Arvanitakis Z, et al. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 2006;66:1837-44 (Pubitemid 44049813)
3. Price JL, Morris JC. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 1999;45:358-68 (Pubitemid 29120041)
4. Galvin JE, Powlishta KK, Wilkins K, et al. Predictors of preclinical Alzheimer disease and dementia: A clinicopathologic study. Arch Neurol 2005;62:758-65 (Pubitemid 40656091)
5. Jack CR Jr, Lowe VJ, Weigand SD, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease. Brain 2009;132: 1355-65
6. Morris JC, Storandt M, McKeel DW Jr, et al. Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease. Neurology 1996;46:707-19
7. Davis DG, Schmitt FA, Wekstein DR, et al. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropathol Exp Neurol 1999;58:376-88 (Pubitemid 29187900)
8. Resnick SM, Sojkova J, Zhou Y, et al. Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology 2010;74:807-15
9. Henneman WJ, Vrenken H, Barnes J, et al. Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology 2009;73:935-40
10. Li G, Sokal I, Quinn JF, et al. CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: A follow-up study. Neurology 2007;69:631-39 (Pubitemid 47256004)
11. Ewers M, Buerger K, Teipel SJ, et al. Multicenter assessment of CSFphosphorylated tau for the prediction of conversion of MCI. Neurology 2007;69:2205-12 (Pubitemid 350294675)
12. Nelson PT, Braak H, Markesbery WR. Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol 2009;68:1-14
13. Perrin RJ, Fagan AM, Holtzman DM. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 2009;461:916-22
14. Price JL, McKeel DW Jr, Buckles VD, et al. Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 2009;30:1026-36
15. Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002;8:448-60 (Pubitemid 34296102)
16. Snowdon DA, Greiner LH, Mortimer JA, et al. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997; 277:813-17 (Pubitemid 27111317)
17. SantaCruz KS, Tasaki CS, Kim RC, et al. Brainstem and cortical Lewy bodies in patients presenting clinically with Alzheimer's disease. J Alzheimers Dis 2002;4:11-17 (Pubitemid 34241000)
18. Nelson PT, Kukull WA, Frosch MP. Thinking outside the box: Alzheimertype neuropathology that does not map directly onto current consensus recommendations. J Neuropathol Exp Neurol 2010;69:449-54
19. Alafuzoff I, Arzberger T, Al-Sarraj S, et al. Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe Consortium. Brain Pathol 2008;18:484-96
20. Snowdon DA, Kemper SJ, Mortimer JA, et al. Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. JAMA 1996;275:528-32 (Pubitemid 26061427)
21. Sonnen JA, Larson EB, Crane PK, et al. Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 2007;62:406-13 (Pubitemid 350105954)
22. Consensus Recommendations for the Postmortem Diagnosis of Alzheimer's Disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997;18:S1-2
23. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
24. Braak H, Alafuzoff I, Arzberger T, et al. Staging of Alzheimer diseaseY associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 2006;112:389-404 (Pubitemid 44469160)
25. Snowdon DA. Aging and Alzheimer's disease: Lessons from the Nun Study. Gerontologist 1997;37:150-56 (Pubitemid 27181271)
26. Morris JC, Heyman A, Mohs RC, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989;39: 1159-65 (Pubitemid 19239715)
27. Chandler MJ, Lacritz LH, Hynan LS, et al. A total score for the CERAD neuropsychological battery. Neurology 2005;65:102-6 (Pubitemid 40967783)
28. Kruiansky J, Gurland B. The performance test of activities of daily living. Int J Aging Hum Dev 1976;7:343-52 (Pubitemid 8065783)
29. Potvin AR, Tourtellotte WW, Dailey JS, et al. Simulated activities of daily living examination. Arch Phys Med Rehabil 1972;53:476-86
30. Riley KP, Snowdon DA, Markesbery WR. Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study. Ann Neurol 2002;51:567-77
31. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (Revised 4th ed.). Washington, DC: American Psychiatric Association, 2000
32. Riley KP, Snowdon DA, Saunders AM, et al. Cognitive function and apolipoprotein E in very old adults: Findings from the Nun Study. J Gerontol B Psychol Sci Soc Sci 2000;55:S69-75 (Pubitemid 30241708)
33. Kukull WA, Higdon R, Bowen JD, et al. Dementia and Alzheimer disease incidence: A prospective cohort study. Arch Neurol 2002;59:1737-46 (Pubitemid 35340484)
34. Tyas SL, Snowdon DA, Desrosiers MF, et al. Healthy ageing in the Nun Study: Definition and neuropathologic correlates. Age Ageing 2007;36: 650-55 (Pubitemid 350258975)
35. Sonnen JA, Larson EB, Haneuse S, et al. Neuropathology in the adult changes in thought study: A review. J Alzheimers Dis 2009;18:703-11
36. Dubois B, Feldman HH, Jacova C, et al. Revising the definition of Alzheimer's disease: A new lexicon. Lancet Neurol 2010;9:1118-27
37. Bancher C, Jellinger K, Lassmann H, et al. Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia. Eur Arch Psychiatry Clin Neurosci 1996;246:137-46 (Pubitemid 26130273)
38. Savva GM, Wharton SB, Ince PG, et al. Age, neuropathology, and dementia. N Engl J Med 2009;360:2302-9
39. Geddes JW, Tekirian TL, Soultanian NS, et al. Comparison of neuropathologic criteria for the diagnosis of Alzheimer's disease. Neurobiol Aging 1997;18:S99-105
40. Erten-Lyons D, Woltjer RL, Dodge H, et al. Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurology 2009;72:354-60