Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 5, 2010, Pages 449-454

  Nelson, Peter T ^a   Kukull, Walter A ^b   Frosch, Matthew P ^c  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer disease; Braak; Consortium to Establish a Registry for Alzheimer Disease; Neurofibrillary tangles; Neuropathology; Plaques

Indexed keywords

ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; BRAAK STAGING SYSTEM; CONSENSUS; CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMER DISEASE; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE SEVERITY; MINI MENTAL STATE EXAMINATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; REGISTER; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; COHORT STUDIES; CONSENSUS; DEMENTIA; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MALE; NEUROFIBRILLARY TANGLES; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 77951879099     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181d8db07     Document Type: Article

References (21)

1. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997;18:S1-2
2. Braak H, Braak E. Stageing of Alzheimer's disease-related neuro-fibrillary changes. Neurobiol Aging 1995;16:271-78; discussion 8-84
3. Mirra SS. The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: A commentary. Neurobiol Aging 1997;18:S91-94
4. Beekly DL, Ramos EM, van Belle G, et al. The National Alzheimer's Coordinating Center (NACC) Database: An Alzheimer disease database. Alzheimer Dis Assoc Disord 2004;18:270-277
5. Nelson PT, Jicha GA, Kryscio RJ, et al. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol 2010;257:359-366
6. Nelson PT, Kryscio RJ, Jicha GA, et al. Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies. Neurology 2009; 73:1127-1133
7. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium. Neurology 2005;65:1863-1872
8. Halliday G, Ng T, Rodriguez M, Harding A, et al. Consensus neuro-pathological diagnosis of common dementia syndromes: Testing and standardising the use of multiple diagnostic criteria. Acta Neuropathol 2002;104:72-78
9. Alafuzoff I, Arzberger T, Al-Sarraj S, et al. Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe Consortium. Brain Pathol 2008;18:484-496
10. Schneider JA, Aggarwal NT, Barnes L, et al. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis 2009. Epub ahead of print
11. Nelson PT, Abner EL, Schmitt FA, et al. Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol November 19, 2008. [Epub ahead of print]
12. Alafuzoff I, Pikkarainen M, Al-Sarraj S, et al. Interlaboratory comparison of assessments of Alzheimer diseaseYrelated lesions: A study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol 2006;65:740-757
13. Alafuzoff I, Thal DR, Arzberger T, et al. Assessment of beta-amyloid deposits in human brain: A study of the BrainNet Europe Consortium. Acta Neuropathol 2009;117:309-320
14. Arriagada PV, Growdon JH, Hedley-Whyte ET, et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 1992;42:631-639
15. Nelson PT, Braak H, Markesbery WR. Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship. J Neuropathol Exp Neurol 2009;68:1-14
16. Ingelsson M, Fukumoto H, Newell KL, et al. Early AA accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 2004;62:925-931
17. Nagy Z, Esiri MM, Jobst KA, et al. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria. Dementia (Basel) 1995;6:21-31
18. Tiraboschi P, Hansen LA, Thal LJ, et al. The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 2004;62:1984-1989
19. Whitwell JL, Josephs KA, Murray ME, et al. MRI correlates of neurofibrillary tangle pathology at autopsy: A voxel-based morphometry study. Neurology 2008;71:743-749
20. Jellinger KA. Criteria for the neuropathological diagnosis of dementing disorders: Routes out of the swamp? Acta Neuropathol 2009;117:101-110
21. Nelson PT, Abner EL, Schmitt FA, et al. Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurology 2009;68:774-784