The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells

Molecular Endocrinology

Volumn 25, Issue 10, 2011, Pages 1699-1709

  Stender, Joshua D ^a   Stossi, Fabio ^a   Funk, Cory C ^a   Charn, Tze Howe ^a   Barnett, Daniel H ^a   Katzenellenbogen, Benita S ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID RECEPTOR; PROGESTERONE RECEPTOR; SMALL INTERFERING RNA;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; ENHANCER REGION; GENE; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PITX1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UPREGULATION;

BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN; ENHANCER ELEMENTS, GENETIC; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; NUCLEIC ACID CONFORMATION; PAIRED BOX TRANSCRIPTION FACTORS; PROTEIN BINDING; UP-REGULATION;

EID: 80053344679     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-0102     Document Type: Article

References (43)

1. Couse JF, Korach KS 1999 Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358-417
2. Deroo BJ, Korach KS 2006 Estrogen receptors and human disease. J Clin Invest 116:561-570
3. Katzenellenbogen BS, Katzenellenbogen JA 2002 Biomedicine. Defining the "S" in SERMs. Science 295:2380-2381
4. Katzenellenbogen BS, Montano MM, Ediger TR, Sun J, Ekena K, Lazennec G, Martini PG, McInerney EM, Delage-Mourroux R, Weis K, Katzenellenbogen JA 2000 Estrogen receptors: selective ligands, partners, and distinctive pharmacology. Recent Prog Horm Res 55:163-193; discussion.
5. Hall JM, Couse JF, Korach KS 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276: 36869-36872
6. McKenna NJ, O'Malley BW 2002 Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-474
7. Rosenfeld MG, Lunyak VV, Glass CK 2006 Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev 20: 1405-1428
8. Sanchez R, Nguyen D, Rocha W, White J.H., Mader S 2002 Diversity in the mechanisms of gene regulation by estrogen receptors. Bioes-says 24:244-254
9. Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeck-houte J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M 2005 Chromosome-wide mapping of estrogen recep-tor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122:33-43
10. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M 2006 Genome-wide analysis of estrogen receptor binding sites. Nat Genet 38:1289-1297
11. Eeckhoute J, Carroll JS, Geistlinger TR, Torres-Arzayus MI, Brown M 2006 A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes Dev 20:2513-2526
12. Laganiere J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguere V 2005 Location analysis of estrogen receptor a target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci USA 102:11651-11656
13. Lin CY, Vega VB, Thomsen JS, Zhang T, Kong SL, Xie M, Chiu KP, Lipovich L, Barnett DH, Stossi F, Yeo A, George J, Kuznetsov VA, Lee YK, Charn TH, Palanisamy N, Miller LD, Cheung E, Katzenellenbogen BS, Ruan Y, Bourque G, Wei CL, Liu ET 2007 Whole-genome cartography of estrogen receptor a binding sites. PLoS Genet 3:e87
14. Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS 2011 Genomic collaboration of estrogen receptor a and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol 31:226-236
15. Stender JD, Kim K, Charn TH, Komm B, Chang KC, Kraus WL, Benner C, Glass CK, Katzenellenbogen BS 2010 Genome-wide analysis of estrogen receptor a DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol 30:3943-3955
16. Welboren WJ, van Driel MA, Janssen-Megens EM, van Heeringen SJ, Sweep FC, Span PN, Stunnenberg HG 2009 ChIP-Seq of ERα and RNA polymerase II defines genes differentially responding to ligands. EMBO J 28:1418-1428
17. Tremblay JJ, Lanctot C, Drouin J 1998 The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodo-maingene Lim3/Lhx3. Mol Endocrinol 12:428-441
18. Kolfschoten IG, van Leeuwen B, Berns K, Mullenders J, Beijersber-gen RL, Bernards R, Voorhoeve PM, Agami R 2005 A genetic screen identifies PITX1 as a suppressor of RAS activity and tumor-igenicity. Cell 121:849-858
19. Szeto DP, RodriguezEsteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisua-Belmonte JC, Rosenfeld MG.1999 Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev 13:484-494
20. Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG 1996 P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. Proc Natl Acad Sci USA 93:7706-7710
21. Lamonerie T, Tremblay JJ, Lanctot C, Therrien M, Gauthier Y, Drouin J 1996 Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev 10:1284-1295
22. Luo M, Koh M, Feng J, Wu Q, Melamed P 2005 Cross talk in hormonally regulated gene transcription through induction of estrogen receptor ubiquitylation. Mol Cell Biol 25:7386-7398
23. Melamed P, Koh M, Preklathan P, Bei L, Hew C 2002 Multiple mechanisms for Pitx-1 transactivation of a luteinizing hormone β subunit gene. J Biol Chem 277:26200-26207
24. Poulin G, Lebel M, Chamberland M, Paradis FW, Drouin J 2000 Specific protein-protein interaction between basic helix-loop-helix transcription factors and homeoproteins of the Pitx family. Mol Cell Biol 20:4826-4837
25. Tremblay JJ, Marcil A, Gauthier Y, Drouin J 1999 Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. EMBO J 18:3431-3441
26. Island ML, Mesplede T, Darracq N, Bandu MT, Christeff N, Djian P, Drouin J, Navarro S 2002 Repression by homeoprotein pitx1 of virus-induced interferon a promoters is mediated by physical interaction and trans repression of IRF3 and IRF7. Mol Cell Biol 22: 7120-7133
27. Frasor J, Stossi F, Danes JM, Komm B, Lyttle CR, Katzenellenbo-gen BS 2004 Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res 64:1522-1533
28. Barnett DH, Sheng S, Charn TH, Waheed A, Sly WS, Lin CY, Liu ET, Katzenellenbogen BS 2008 Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer. Cancer Res 68:3505-3515
29. Deschenes J, Bourdeau V, White JH, Mader S 2007 Regulation of GREB1 transcription by estrogen receptor a through a multipartite enhancer spread over 20 kb of upstream flanking sequences. J Biol Chem 282:17335-17539
30. Fullwood MJ, Liu MH, Pan YF, Liu J, Xu H, Mohamed YB, Orlov YL, Velkov S, Ho A, Mei PH, Chew EG, Huang PY, Welboren WJ, Han Y, Ooi HS, Ariyaratne PN, Vega VB, Luo Y, Tan PY, Choy PY, Wansa KD, Zhao B, Lim KS, Leow SC, Yow JS, et al. 2009 An oestrogen-receptor-a-bound human chromatin interactome. Nature 462:58-64
31. He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M, Liu XS 2010 Nucleosome dynamics define transcriptional enhancers. Nat Genet 42:343-347
32. Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M 2008 FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 132:958-970
33. Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S 2006 X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 9:121-132
34. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM 2004 ONCOMINE: acancer microarray database and integrated data-mining platform. Neoplasia 6:1-6
35. Luo JH, Yu YP, Cieply K, Lin F, Deflavia P, Dhir R, Finkelstein S, Michalopoulos G, Becich M. 2002 Gene expression analysis of prostate cancers. Mol Carcinog 33:25-35
36. Magee JA, Araki T, Patil S, Ehrig T, True L, Humphrey PA, Cata-lona WJ, Watson MA, Milbrandt J 2001 Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res 61: 5692-5696
37. Ediger TR, Kraus WL, Weinman EJ, Katzenellenbogen BS 1999 Estrogen receptor regulation of the Na+/H+ exchange regulatory factor. Endocrinology 140:2976-2982
38. Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS 2003 Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144:4562-4574
39. Stender JD, Frasor J, Komm B, Chang KC, Kraus WL, Katzenellenbogen BS 2007 Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. Mol Endocrinol 21:2112-2123
40. Rajendran RR, Nye AC, Frasor J, Balsara RD, Martini PG, Katzenellenbogen BS 2003 Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97). J Biol Chem 278:4628-4638
41. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M 2000 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852
42. Frasor J, Danes JM, Funk CC, Katzenellenbogen BS 2005 Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc Natl Acad Sci USA 102:13153-13157
43. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK 2010 Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38: 576-589