The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation

Transplantation

Volumn 92, Issue 7, 2011, Pages 787-795

  Vitalone, Matthew J ^a   Naesens, Maarten ^b   Sigdel, Tara ^a   Li, Li ^a   Hseih, Sue ^a   Sarwal, Minnie M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Chronic allograft injury; Epithelial to mesenchymal transition; Pediatric transplantation; Tubulointerstitial damage

Indexed keywords

CALCINEURIN INHIBITOR; SCATTER FACTOR; UVOMORULIN;

ARTICLE; CHILD; CHRONIC ALLOGRAFT INJURY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GRAFT RECIPIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NEPHROTOXICITY; PEDIATRICS; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; SCORING SYSTEM; SIGNAL TRANSDUCTION; UPREGULATION;

ADOLESCENT; ALGORITHMS; ATROPHY; BIOPSY; CHILD; CHILD, PRESCHOOL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FIBROSIS; GRAFT REJECTION; HUMANS; KIDNEY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MALE; MICROARRAY ANALYSIS; RETROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS;

EID: 80053339743     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31822d092c     Document Type: Article

References (54)

1. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
2. Nankivell BJ, Fenton-Lee CA, Kuypers DR, et al. Effect of histological damage on long-term kidney transplant outcome. Transplantation 2001; 71: 515.
3. Nankivell BJ, Borrows RJ, Fung CL, et al. Natural history, risk factors, and impact of subclinical rejection in kidney transplantation. Transplantation 2004; 78: 242.
4. Neilson EG. Setting a trap for tissue fibrosis. Nat Med 2005; 11: 373.
5. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15: 1.
6. Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001; 159: 1465.
7. El-Nahas AM. Plasticity of kidney cells: Role in kidney remodeling and scarring. Kidney Int 2003; 64: 1553.
8. Iwano M, Plieth D, Danoff TM, et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341.
9. Vongwiwatana A, Tasanarong A, Rayner DC, et al. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis.AmJ Transplant 2005; 5: 1367.
10. Djamali A, Reese S, Oberley T, et al. Heat shock protein 27 in chronic allograft nephropathy: A local stress response. Transplantation 2005; 79: 1645.
11. Hertig A, Verine J, Mougenot B, et al. Risk factors for early epithelial to mesenchymal transition in renal grafts. Am J Transplant 2006; 6: 2937.
12. Vitalone MJ, O'Connell PJ, Jimenez-Vera E, et al. Epithelial- tomesenchymal transition in early transplant tubulointerstitial damage. J Am Soc Nephrol 2008; 19: 1571.
13. Duffield JS. Epithelial to mesenchymal transition in injury of solid organs: Fact or artifact? Gastroenterology 2010; 139: 1081, 1083 e1.
14. Callahan KL, Beck NK, Duffield EA, et al. Inactivation of methicillinresistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) on various environmental surfaces by mist application of a stabilized chlorine dioxide and quaternary ammonium compound-based disinfectant. J Occup Environ Hyg 2010; 7: 529.
15. McMorrow T, Gaffney MM, Slattery C, et al. Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells. Nephrol Dial Transplant 2005; 20: 2215.
16. Slattery C, Campbell E, McMorrow T, et al. Cyclosporine A-induced renal fibrosis:Arole for epithelial-mesenchymal transition.AmJ Pathol 2005; 167: 395.
17. Naesens M, Kambham N, Concepcion W, et al. The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant 2007; 7: 2504.
18. Naesens M, et al. Microarray expression profiling associates progressive histological damage of renal allografts with innate and adaptive immunity. Kidney Int 2011; (in press).
19. Dai C, Liu Y. Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol 2004; 15: 1402.
20. Deuse T, Peter C, Fedak PW, et al. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation 2009; 120(11 suppl): S247.
21. Salvatierra O, Concepcion W, Sarwal M. A critical look at the immunologically favorable adult-sized kidney transplant in small children. Pediatr Transplant 2009; 13: 265.
22. SalvatierraOJr, Sarwal M. Renal perfusion in infant recipients of adultsized kidneys is a critical risk factor. Transplantation 2000; 70: 412.
23. Salvatierra O Jr, Singh T, Shifrin R, et al. Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow. Transplantation 1998; 66: 819.
24. SalvatierraOJr, Singh T, Shifrin R, et al. Transplantation of adult-sized kidneys into infants induces major blood flow changes. Transplant Proc 1999; 31: 236.
25. Nankivell BJ, Borrows RJ, Fung CL, et al. Calcineurin inhibitor nephrotoxicity: Longitudinal assessment by protocol histology. Transplantation 2004; 78: 557.
26. Nankivell BJ, Chapman JR. The significance of subclinical rejection and the value of protocol biopsies. Am J Transplant 2006; 6: 2006.
27. Mengel M, Gwinner W, Schwarz A, et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007; 7: 356.
28. Mengel M, Reeve J, Bunnag S, et al. Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts.AmJ Transplant 2009; 9: 1859.
29. Barasch J, Yang J, Ware CB, et al. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell 1999; 99: 377.
30. Plisov SY, Yoshino K, Dove LF, et al. TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis. Development 2001; 128: 1045.
31. Baum B, Settleman J, Quinlan MP. Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol 2008; 19: 294.
32. Thiery JP, Sleeman JP. Complex networks orchestrate epithelialmesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7: 131.
33. Moreno-Bueno G, Cubillo E, Sarrió D, et al. Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res 2006; 66: 9543.
34. Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: Implications in development and cancer. Development 2005; 132: 3151.
35. Chen R, Sigdel TK, Li L, et al. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol 2010; 6: pii: e1000940.
36. Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 2003; 14(suppl 1): S55.
37. Gröne HJ, Weber K, Gröne E, et al. Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 1987; 129: 1.
38. Ishibe S, Cantley LG. Epithelial-mesenchymal-epithelial cycling in kidney repair. Curr Opin Nephrol Hypertens 2008; 17: 379.
39. Montesano R, Matsumoto K, Nakamura T, et al. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 1991; 67: 901.
40. Ishibe S, Haydu JE, Togawa A, et al. Cell confluence regulates hepatocyte growth factor-stimulated cell morphogenesis in a beta-catenindependent manner. Mol Cell Biol 2006; 26: 9232.
41. Karihaloo A, O'Rourke DA, Nickel C, et al. Differential MAPK pathways utilized for HGF-and EGF-dependent renal epithelial morphogenesis. J Biol Chem 2001; 276: 9166.
42. Tilghman RW, Slack-Davis JK, Sergina N, et al. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci 2005; 118(pt 12): 2613.
43. Zhuang S, Yan Y, Han J, et al. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J Biol Chem 2005; 280: 21036.
44. O'Brien LE, Tang K, Kats ES, et al. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell 2004; 7: 21.
45. Hellman NE, Spector J, Robinson J, et al. Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for Madin-Darby canine kidney tubulogenesis. J Biol Chem 2008; 283: 4272.
46. Sarwal MM, Vidhun JR, Alexander SR, et al. Continued superior outcomes with modification and lengthened follow-up of a steroidavoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation 2003; 76: 1331.
47. Li L, Chang A, Naesens M, et al. Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained graft and patient benefits. Am J Transplant 2009; 9: 1362.
48. Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: New diagnostic insights and standards. Am J Transplant 2004; 4: 1562.
49. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
50. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008; 8: 753.
51. Isoniemi H, Taskinen E, Hayry P. Histological chronic allograft damage index accurately predicts chronic renal allograft rejection. Transplantation 1994; 58: 1195.
52. Nagarajan S, Shah S, Troxell M, et al.Anovel drug toxicity pathology score in protocol biopsies can predict clinical graft and patient outcomes in pediatric renal transplantation. Boston, MA, American Transplant Congress 2004.
53. Chen R, Li L, Butte A. AILUN: Reannotating gene expression data automatically. Nat Methods 2007; 4: 879. (Pubitemid 350042367)
54. Vitalone MJ, O'Connell PJ, Wavamunno M. Transcriptome changes of chronic tubulointerstitial damage in early kidney transplantation. Transplantation 2010; 89: 537.