Epithelial-mesenchymal-epithelial cycling in kidney repair

Current Opinion in Nephrology and Hypertension

Volumn 17, Issue 4, 2008, Pages 379-385

  Ishibe, Shuta ^a   Cantley, Lloyd G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute kidney injury; Beta catenin; Growth factors; Tubulogenesis; Wnt

Indexed keywords

BETA CATENIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SCATTER FACTOR; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

CELL CYCLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CELL REGENERATION; ENZYME ACTIVATION; HUMAN; KIDNEY CELL; KIDNEY INJURY; KIDNEY TUBULE EPITHELIUM; MESENCHYME CELL; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVIEW; ANIMAL; CYTOLOGY; EPITHELIUM; GROWTH, DEVELOPMENT AND AGING; KIDNEY; KIDNEY DISEASE; KIDNEY TUBULE; MESODERM; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; EPITHELIUM; HUMANS; KIDNEY; KIDNEY DISEASES; KIDNEY TUBULES; MESODERM; WNT PROTEINS;

EID: 55249122465     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3283046507     Document Type: Review

References (58)

1. Bonventre JV, Kelly KJ. Adhesion molecules and acute renal failure. Adv Nephrol Necker Hosp 1996; 25:159-176.
2. Schrier RW, Wang W, Poole B, Mitra A. Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest 2004; 114:5-14.
3. Lin F, Moran A, Igarashi P. Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. J Clin Invest 2005; 115:1756-1764.
4. Cantley LG. Adult stem cells in the repair of the injured renal tubule. Nat Clin Pract Nephrol 2005; 1:22-32.
5. Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 2003; 14 (Suppl 1):S55-S61.
6. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112:1776-1784.
7. Grone HJ, Weber K, Grone E, et al. Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 1987; 129:1-8.
8. Vongwiwatana A, Tasanarong A, Rayner DC, et al. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 2005; 5:1367-1374.
9. Villanueva S, Cespedes C, Vio CP. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am J Physiol Regul Integr Comp Physiol 2006; 290:R861-R870.
10. Witzgall R, Brown D, Schwarz C, Bonventre JV. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 1994; 93:2175-2188.
11. Kwon O, Nelson WJ, Sibley R, et al. Backleak, tight junctions, and cell- cell adhesion in postischemic injury to the renal allograft. J Clin Invest 1998; 101:2054-2064.
12. Zhang SL, GuoJ, Moini B, Ingelfinger JR. Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis. Kidney Int 2004; 66:2181-2192.
13. Safirstein RL. Lessons learned from ischemic and cisplatin-induced nephrotoxicity in animals. Ren Fail 1999; 21:359-364.
14. Surendran K, Simon TC. CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am J Physiol Renal Physiol 2003; 284:F653-662.
15. Imgrund M, Grone E, Grone HJ, et al. Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice 1. Kidney Int 1999; 56:1423-1431.
16. Rogers SA, Miller SB, Hammerman MR. Enhanced renal IGF-I expression following partial kidney infarction. Am J Physiol Renal Physiol 1993; 264:F963-F967.
17. Abbate M, Brown D, Bonventre JV. Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia. Am J Physiol 1999; 277:F454-F463.
18. Matsumoto K, Nakamura T. Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases. Kidney Int 2001; 59:2023-2038.
19. Cuevas P, Martinez-Coso V, Fu X, et al. Fibroblast growth factor protects the kidney against ischemia-reperfusion injury. Eur J Med Res 1999; 4:403-410.
20. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127:469-480.
21. Stark K, Vainio S, Vassileva G, McMahon AP. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 1994; 372:679-683.
22. Carroll TJ, Park JS, Hayashi S, et al. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 2005; 9:283-292.
23. Majumdar A, Vainio S, Kispert A, et al. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 2003; 130:3175-3185.
24. Merkel CE, Karner CM, Carroll TJ. Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol 2007; 22:1825-1838.
25. KuureS, PopsuevaA, Jakobson M, et al. Glycogen synthase kinase-3 inactivation and stabilization of beta-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymes. J Am Soc Nephrol 2007; 18:1130-1139.
26. Benzing T, Simons M, Walz G. Wnt signaling in polycystic kidney disease. J Am Soc Nephrol 2007; 18:1389-1398.
27. Terada Y, Tanaka H, Okado T, et al. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol 2003; 14:1223-1233.
28. Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16:2373-2384.
29. Price VR, Reed CA, Lieberthal W, Schwartz JH. ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of beta-catenin and LEF-1. J Am Soc Nephrol 2002; 13:1152-1161.
30. Joannidis M, Spokes K, Nakamura T, et al. Regional expression of hepatocyte growth factor/c-met in experimental renal hypertrophy and hyperplasia. Am J Physiol Renal Physiol 1994; 267:F231-F236.
31. MongaSP, Mars WM, Pediaditakis P, et al. Hepatocyte growth factor induces Wnt-independent nucleartranslocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 2002; 62:2064-2071.
32. BrabletzT, Jung A, Reu S, et al. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A 2001; 98:10356-10361.
33. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004; 303:1483-1487.
34. ZukA, Bonventre JV, Brown D, Matlin KS. Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol Cell Physiol 1998; 275:C711-C731.
35. Basile DP, Martin DR, Hammerman MR. Extracellular matrix-related genes in kidney after ischemic injury: potential role for TGF-beta in repair. Am J Physiol Renal Physiol 1998; 275:F894-903.
36. Jiang ST, Chiu SJ, Chen HC, et al. Role of alpha(3)beta(1) integrin in tubulogenesis of Madin-Darby canine kidney cells. Kidney Int 2001; 59:1770-1778.
37. Yook JI, Li XY, Ota I, et al. A Wnt-Axin2-GSK3beta cascade regulates Snail 1 activity in breast cancer cells. Nat Cell Biol 2006; 8:1398-1406.
38. Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res 2006; 66:4549-4552.
39. Leroy P, Mostov KE. Slug is required for cell survival during partial epithelial mesenchymal transition of HGF-induced tubulogenesis. Mol Biol Cell 2007; 18:1943-1952.
40. YoshinoJ, MonkawaT, Tsuji M, et al. Snail1 is involved in the renal epithelialmesenchymal transition. Biochem Biophys Res Commun 2007; 362:63-68.
41. Pollack AL, Barth AI, Altschuler Y, et al. Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis. J Cell Biol 1997; 137:1651-1662.
42. Montesano R, Schaller G, Orci L. Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell 1991; 66:697-711.
43. Rosario M, Birchmeier W. How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol 2003; 13:328-335.
44. Brown MC, Turner CE. Paxillin: adapting to change. Physiol Rev 2004; 84:1315-1339.
45. Karihaloo A, O'Rourke DA, Nickel C, et al. Differential MAPK pathways utilized for HGF- and EGF-dependent renal epithelial morphogenesis. J Biol Chem 2001; 276:9166-9173.
46. Liu ZX, Yu CF, Nickel C, et al. Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association. J Biol Chem 2002; 277:10452-10458.
47. Ishibe S, Joly D, Zhu X, Cantley LG. Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol Cell 2003; 12:1275-1285.
48. Ishibe S, Joly D, Liu ZX, Cantley LG. Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Mol Cell 2004; 16:257-267.
49. Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005; 6:827-837.
50. Tilghman RW, Slack-Davis JK, Sergina N, et al. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci 2005; 118:2613-2623.
51. Zhuang S, Yan Y, Han J, Schnellmann RG. p38 kinase-mediated transactiva-tion of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J Biol Chem 2005; 280:21036-21042.
52. Zeng F, Zhang MZ, Singh AB, et al. ErbB4 isoforms selectively regulate • growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell 2007; 18:4446-4456. This study demonstrated that EGF can induce tubulogenesis via activation of the MAPK pathway.
53. Masszi A, Fan L, Rosivall L, et al. Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to- myofibroblast transition: role for beta-catenin. Am J Pathol 2004; 165:1955-1967.
54. Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM. Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model. J Cell Biol 2005; 171:663-673.
55. Karihaloo A, Karumanchi SA, Cantley WL, et al. Vascular endothelial growth factor induces branching morphogenesis/tubulogenesis in renal epithelial cells in a neuropilin-dependent fashion. Mol Cell Biol 2005; 25:7441-7448.
56. IshibeS, Haydu JE, Togawa A, et al. Cell confluency regulates Hgf-stimulated cell morphogenesis in a β-catenin dependent manner. Mol Cell Biol 2006; 26:9232-9243.
57. O'Brien LE, Tang K, Kats ES, et al. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell 2004; 7:21-32.
58. Hellman NE, Spector J, Robinson J, et al. Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for MDCK tubulogenesis. J Biol Chem 2008; 283:4272-4282.