Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta

Vascular Health and Risk Management

Volumn 7, Issue 1, 2011, Pages 273-280

  Xue, Yong Liang ^a   Shi, Hai Xia ^a   Murad, Ferid ^a,b   Bian, Ka ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai Universities   (China)

Author keywords

Cinnamaldehyde; Endothelium; Vascular smooth muscle cell; Vasodilation

Indexed keywords

ACROLEIN; CALCIUM; CINNAMALDEHYDE; DRUG DERIVATIVE;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; MALE; METABOLISM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ACROLEIN; ANIMALS; AORTA, THORACIC; CALCIUM; ENDOTHELIUM, VASCULAR; MALE; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASODILATION;

EID: 80053330263     PISSN: 11766344     EISSN: 11782048     Source Type: Journal    
DOI: 10.2147/VHRM.S15429     Document Type: Article

References (24)

1. Teng Jia-lin T, Li Xing-Guang, Le Yin-Min. Chinese-English bilingual textbooks for international students of Chinese TCM institutions. Chinese Materia Medica. Beijing, China: People's Medical Publishing House; 2007.
2. Amin KA, Abd El-Twab TM. Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolemic rats: Role of atorvastatin and cinnamon. Int J Clin Exp Med. 2009;2(3):254-265.
3. Panickar KS, Polansky MM, Anderson RA. Cinnamon polyphenols attenuate cell swelling and mitochondrial dysfunction following oxygenglucose deprivation in glial cells. Exp Neurol. 2009;216(2):420-427.
4. Kwon HK, Jeon WK, Hwang JS, et al. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. Cancer Lett. 2009;278(2):174-182.
5. Peterson DW, George RC, Scaramozzino F, et al. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis. 2009;17(3):585-597.
6. Wei RP, Huang YF, Hu DH, Zheng YG. Status and trends of researches on Cinnamomum cassia Presl. Nonwood Forest Research. 2006;24(3): 65-70.
7. 2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1. Biol Pharm Bull. 2008;31(3):426-430.
8. Chao LK, Hua KF, Hsu HY, et al. Cinnamaldehyde inhibits pro-inflammatory cytokine secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem Toxicol. 2008;46:220-231.
9. Liao BC, Hsieh CW, Liu YC, Tzeng TT, Sun YW, Wung BS. Cinnamaldehyde inhibits the tumor necrosis factor--induced expression of cell adhesion molecules in endothelial cells by suppressing NF-B activation: Effects upon IB and Nrf2. Toxicol Appl Pharmacol. 2008;292(2):161-171.
10. Huang J, Wang S, Luo X, et al. Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents. Thromb Res. 2007;119(3): 337-342.
11. Takenaga M, Hirai A, Terano T, et al. In vitro effect of cinnamic aldehyde, a main component of Cinnamomi cortex, on human platelet aggregation and arachidonic acid metabolism. J Pharmacobiodyn. 1987; 10(5):201-208.
12. Xu Ming, Yu Lu, Ding Yuan-yuan, et al. Experimental study on hypotensive effects of cinnamaldehyde in anesthetized rats. Chin Heart J. 2006;28(3):272-276.
13. Yanaga A, Goto H, Nakagawa T, et al. Cinnamaldehyde induces endothelium-dependent and-independent vasorelaxant action on isolated rat aorta. Biol Pharm Bull. 2006;29(12):2415-2418.
14. Zhang Tuan-xiao, Niu Cai-qin, Jing Hua-e, et al. Effect of water decoction of the Gastrodia elata BI on vasodiIation of rabbit aorta in vitro. Journal of Clinical Rehabilitative Tissue Engineering Research. 2008;13(1):203988-203991.
15. Bian K, Toda N. Reoxygenation and calcium-induced cerebroarterial contractions as affected by vasodilator agents. J Cereb Blood Flow Metab. 1988;8(6):808-815.
16. Bian K, Doursout MF, Murad F. Vascular system: Role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich). 2008;10(4): 304-310.
17. Bian K, Murad F. Nitric oxide (NO)-biogeneration, regulation, and relevance to human diseases. Front Biosci. 2003;8:d264-d278.
18. Martin W, Villani GM, JotIlianandan D. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther. l985;232(3):708-7l6.
19. Jia Hong-jun, Wang Zhong-ling, Yang Qi-dong. Ion Channels and Cardio-Cerebrovascular Diseases Basic Science and Clinical Practice. Beijing, China: People's Health Press; 2001.
20. 2+ channel in rat vascular muscle. J Vasc Res. 1994;31(5): 256-264.
21. Liu ZX. Practical Cardiovascular Receptorology. Beijing, China: Science Press; 2001.
22. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: Dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003; 4(7):517-529.
23. 2+channel antagonist Ro 40-5967 in vascular muscle cells cultured from dog coronary and saphenous arteries. Naunyn Schmiedebergs Arch Pharmacol. 1993;348(2):191-196.
24. Yao T. Physiology. Beijing, China: People's Health Press; 2003.