Clarifying the mechanism of superantigen toxicity

PLoS Biology

Volumn 9, Issue 9, 2011, Pages

  Fraser, John D ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIUM LIPOPOLYSACCHARIDE; CD28 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL PROTEIN; ENTEROTOXIN; ENTEROTOXIN A, STAPHYLOCOCCAL; ENTEROTOXIN B, STAPHYLOCOCCAL; IL2 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN ANTIBODY REACTION; ARTICLE; BACTERIAL VIRULENCE; CELLULAR IMMUNITY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MICROBIAL ACTIVITY; NONHUMAN; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; SYMPTOM; T LYMPHOCYTE; TOXIC SHOCK SYNDROME; ANTIGEN PRESENTATION; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; SEPTIC SHOCK; STAPHYLOCOCCUS; STREPTOCOCCUS;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; ENTEROTOXINS; HUMANS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; INTERLEUKIN-2; RECEPTORS, ANTIGEN, T-CELL; SHOCK, SEPTIC; STAPHYLOCOCCUS; STREPTOCOCCUS; SUPERANTIGENS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053325170     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001145     Document Type: Article

References (22)

1. Kotb M, Fraser J. D, eds. (2008) Superantigens: molecular basis for their role in human diseases Washington ASM Press.
2. Todd J, Fishaut M, Kapral F, Welch T, (1978) Toxic-shock syndrome associated with phage-group-I Staphylococci. Lancet 2: 1116-1118.
3. Chesney P. J, Bergdoll M. S, Davis J. P, Vergeront J. M, (1984) The disease spectrum, epidemiology, and etiology of toxic-shock syndrome. Annu Rev Microbiol 38: 315-338.
4. Miethke T, Duschek K, Wahl C, Heeg K, Wagner H, (1993) Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1. Eur J Immunol 23: 1494-1500.
5. Bette M, Schafer M. K, van Rooijen N, Weihe E, Fleischer B, (1993) Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen. J Exp Med 178: 1531-1539.
6. Li H, Llera A, Malchiodi E. L, Mariuzza R. A, (1999) The structural basis of T cell activation by superantigens. Annu Rev Immunol 17: 435-466.
7. Jardetzky T. S, Brown J. H, Gorga J. C, Stern L. J, Urban R. G, et al. (1994) Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature 368: 711-718.
8. Li Y. L, Li H. M, Dimasi N, McCormick J. K, Martin R, et al. (2001) Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity 14: 93-103.
9. Saline M, Rodstrom K. E, Fischer G, Orekhov V. Y, Karlsson B. G, et al. (2010) The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Nat Commun 1: 119.
10. DaSilva L, Welcher B. C, Ulrich R. G, Aman M. J, David C. S, et al. (2002) Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines. J Infect Dis 185: 1754-1760.
11. Mittrucker H. W, Shahinian A, Bouchard D, Kundig T. M, Mak T. W, (1996) Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice. J Exp Med 183: 2481-2488.
12. Saha B, Harlan D. M, Lee K. P, June C. H, Abe R, (1996) Protection against lethal toxic shock by targeted disruption of the CD28 gene. J Exp Med 183: 2675-2680.
13. Suntharalingam G, Perry M. R, Ward S, Brett S. J, Castello-Cortes A, et al. (2006) Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355: 1018-1028.
14. Arad G, Levy R, Hillman D, Kaempfer R, (2000) Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation. Nat Med 6: 414-421.
15. Corry D. B, Lewis D. E, (2006) Cytokine storm and an anti-CD28 monoclonal antibody. N Engl J Med 355: 2592; author reply 2593-2594.
16. Arad G, Levy R, Nasie I, Hillman D, Rotfogel Z, et al. (2011) Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock. Plos Biol 9: e1001149 doi:10.1371/journal.pbio.1001149.
17. Miethke T, Wahl C, Heeg K, Echtenacher B, Krammer P. H, et al. (1992) T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J Exp Med 175: 91-98.
18. Venkatraman P, Nguyen T. T, Sainlos M, Bilsel O, Chitta S, et al. (2007) Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nat Chem Biol 3: 222-228.
19. Cho S, Swaminathan C. P, Yang J, Kerzic M. C, Guan R, et al. (2005) Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction. Structure 13: 1775-1787.
20. Kim J, Urban R. G, Strominger J. L, Wiley D. C, (1994) Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science 266: 1870-1874.
21. Bonsor D. A, Sundberg E. J, (2010) Crystal structure of Toxic Shock Syndrome Toxin 1 (TSST-1) in complex with the human T cell receptor beta chain Vbeta2.1 (EP-8). RCSB Protein Data Bank 3MFG.
22. Sundberg E. J, Li H, Llera A. S, McCormick J. K, Tormo J, et al. (2002) Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes. Structure 10: 687-699.